Triple-negative
A CLDN1-negative phenotype predicts poor prognosis in triple-negative breast cancer.
... cases. Triple- negative breast cancer was defined as estrogen receptor/progesterone receptor ,1% [24] and HER2 0, 1+ or 2+ (with negative fluorescence by in situ hybridization) on ...indicate ...
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Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer.
... cancer, triple-negative breast ...in triple-negative breast ...in triple-negative breast cancer ...MDA-MB-231 triple-negative breast cancer xenografts for four ...
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Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures.
... 73.9% in finding and validation cohort, respectively). Regarding histological grading the proportion of grade 3 tumors is 73.5% and 74.1% in finding and validation cohort, respectively (Table S7). These numbers are ...
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Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model.
... Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor ...
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There is no association between microRNA gene polymorphisms and risk of triple negative breast cancer in a Chinese Han population.
... Triple-negative breast cancer (TNBC) is defined by the lack of the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). It is characterized ...
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Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.
... for triple-negative breast cancer (TNBC) are limited; intermediate-conductance calcium-activated potassium (SK4) channels are closely involved in tumor progression, but little is known about these channels ...
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Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer
... 2010). Triple-negative breast cancer (TNBC) is a subtype characterized by the lack of ER, PR, and HER2 expression and is associated with younger age at diagnosis (Dent et ...
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How many diseases is triple negative breast cancer: the protagonism of the immune microenvironment
... The remaining cases are termed triple negative BC (TNBC), breast carcinomas that neither express ER nor PgR and do not have overexpression of HER2. TNBC can represent between 10% to 20% of all BC cases 8 ...
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Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype.
... DKK1, which interacts with LPR6 of Wnt/beta-catenin pathway, is regulated by progesterone in normal endometrical stroma cells [23]. Consistent with our result, Forget MA [19] and co-workers had also observed DKK1 in two ...
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A prognostic model for triple-negative breast cancer patients based on node status, cathepsin-D and Ki-67 index.
... Ki-67 is a non-histone nuclear protein that is closely linked to proliferation cells. High Ki-67 expression is associated with a higher histologic grade, larger tumor size, the presence of axillary lymph nodal ...
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Increased macroH2A1.1 expression correlates with poor survival of triple-negative breast cancer patients.
... Triple-Negative Breast Cancer (TNBC) is clinically defined by the lack of expression of the estrogen (ER) and progesterone (PgR) receptor genes, and by the absence of amplification of human epidermal growth ...
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Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.
... Triple-negative breast cancer (TNBC), i.e., breast cancer characterized by no immunohisto- chemical expression of the estrogen receptor (ER) or progesterone receptor (PR) and the absence of human epidermal ...
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Androgen receptor expression in triple-negative breast cancer
... the triple-negative breast cancer increases with age, it comprises approximately 15% to 20% of all breast cancers [25, 45] although TNBC are more common than ER positive BC in younger patients (<50 ...
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The differences in ultrasound and clinicopathological features between basal-like and normal-like subtypes of triple negative breast cancer.
... Basal-like tumors comprise an important heterogeneous group of breast cancers associated with aggressive behavior and poor prognosis. They account for 15% of all breast cancers and often present as interval cancers that ...
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HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice.
... In the present study, we demonstrated that HET0016 treatment decreased tumor growth and cell proliferation in breast cancer xenograft model. HET0016 has been reported to be a selective c[r] ...
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Caracterização da expressão de microRNAS em carcinoma de mama triplo negativo
... Descriptors: MicroRNAs; Triple negative breast neoplasms/pathology; Triple negative breast neoplasms/diagnosis; Triple negative breast neoplasms/genetics; Real-time polymerase cha[r] ...
177
Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53.
... In the present study, we have shown that the extract of an ethanolic fraction of Origanum majorana inhibited the proliferation of the mutant p53 triple negative breast cancer (TNBC) cell line, MDA-MB-231. ...
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Rev. Bras. Ginecol. Obstet. vol.37 número7
... with negative axillary metastasis, while 76/239 ...by triple-negative and HER2 subtypes (Figure ...with triple- negative tumors had approximately a 90% lower chance of developing lymph ...
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New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.
... The sp 2 -iminosugar glycosides CO-OCS and SO-OCS are able to induce cell cycle arrest and apoptosis in triple positive MCF-7 and triple negative MDA-MB-231 cells, while they exert no effect on ...
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J. Bras. Patol. Med. Lab. vol.51 número6
... The triple negative subgroup has poor prognosis and aggressive biological ...with triple-negative invasive breast cancer in the Campos Gerais region of ...showed negative for hormone ...
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