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Tumor suppressor

A new tumor suppressor that regulates tissue architecture.

A new tumor suppressor that regulates tissue architecture.

... DEAR1 maps close to another tumor suppressor, CHD5, which was recently mapped to Chromosome 1q by a chromo- some engineering approach [10]. With the identification of DEAR1 we are beginning to develop a ...

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VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer.

VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer.

... VEZT’s tumor-inhibiting function, we screened the target genes regulated by ...in tumor proliferation, invasion, migration, prognosis and therapeutic response ...VEZT tumor suppressor gene on ...

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Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.

Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.

... and tumor formation both in vitro and in vivo by activating the cell cycle suppressor p27 Kip1 , suggesting that KLF4 works as a tumor suppressor in cervical ...many tumor suppression ...

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The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5.

The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5.

... the tumor suppressor role of miR-217 in GC, we used luciferase reporter assay and western blot to confirm that GPC5 was a target of miR-217 in GC ...

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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.

... the tumor suppressor effects of JMJD3 through hypermethylation of an evolutionarily conserved intragenic and enhancer-like DNA regulatory element within the JMJD3 locus or direct somatic mutations of the ...

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Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells.

Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells.

... Human tumor suppressor gene WWOX encodes the mRNA for translating into WWOX/WOX1, WOX2 and other isoforms (if present) ...a tumor suppressor is ...the tumor suppressor function ...

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Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.

Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.

... inhibited tumor cell growth by reducing miR-21 expression in renal cell carcinoma ...a tumor suppressor function, regulating ‘Notch signaling’ by down-regulation of ...a tumor ...

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Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines

Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines

... Epigenetic mechanisms are frequently deregulated in cancer cells and can lead to the silencing of genes with tumor suppressor activities. The isoform A of the Ras-association domain family member 1 ...

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Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

... WWOX , the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth. Since we are interested in ...

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Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor.

Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor.

... The Drosophila and mammalian forms of TSG101 are quite similar at a primary sequence level (46% identical/61% similar), share the same domain structure [5], and are predicted to have very similar molecular properties. ...

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Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.

Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.

... We show that inhibition of erbB2 signaling, either genetically or by small chemical inhibitors, leads to suppression of EMT and a neoplastic phenotype in pen/lgl2 mutant larvae. Intriguingly, E-cad membrane localization ...

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A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.

... Epithelial malignancies such as colorectal and breast cancer are thought to arise and progress towards malignancy due to alterations in signal transduction pathways that regulate the balance between self-renewal and ...

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Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

... WITH TUMOR SUPPRESSOR GENE p53 IN BREAST CARCINOMA Correlation of standard pathomorphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast ...

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The LKB1 tumor suppressor as a biomarker in mouse and human tissues.

The LKB1 tumor suppressor as a biomarker in mouse and human tissues.

... major tumor suppressor in diverse malignancies, particularly melanoma, cervical cancer, and lung cancer ...LKB1 tumor suppressor functions ...

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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.

Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.

... absolute tumor volume was not statistically different between all three genotypes (total tumor volume alone or as a percentage of the retinal ...fewer tumor-initiating cells, we conclude that ...

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High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

... We have also experimentally tested whether RASSF1A (genomic DNA, exons1 and 2) harbored mutations in normal tissues and found one mutated clone out of 14 in normal kidney (normal control to T356, see section ‘‘Frequent ...

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DNA methylation analysis of the tumor suppressor gene CDKN2B

DNA methylation analysis of the tumor suppressor gene CDKN2B

... methylation contributes to carcinogenesis and is responsi- ble for the chromosomal instability, reactivation of transposable elements, and loss of imprinting (Esteller and Herman, 2002). Therefore, the profile of ...

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Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells.

Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells.

... its tumor suppressive functions in key ...convey tumor suppressive functions that coordinate the activities of the p53 and Rb signaling ‘‘pathways,’’ inactivation of Arf and Ink4a in the testes leads to ...

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Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

... p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells. How p53 selects target genes in the genome ...

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The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.

The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.

... Malignant diseases are caused by defects in cell differentiation, cell cycle progression, DNA repair mechanisms, or apoptotic pathways [55–57]. Although previous studies have revealed the genetic backgrounds of certain ...

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