Tumor Suppressor Gene
Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor.
... The Drosophila and mammalian forms of TSG101 are quite similar at a primary sequence level (46% identical/61% similar), share the same domain structure [5], and are predicted to have very similar molecular properties. ...
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ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer.
... ‘‘repressive’’ gene signature could be attributed to the dysregulated activation of epigenetic effectors like EZH2 by ETS factors leading to silencing of genes with potential anti-tumor activity ...Nkx3.1 ...
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Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma
... WITH TUMOR SUPPRESSOR GENE p53 IN BREAST CARCINOMA Correlation of standard pathomorphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in ...
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Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.
... WWOX tumor suppressor gene is inactivated in many types of human cancers by genomic rearrangements, aberrant mRNA splicing, homozygous deletions and epigenetic silencing ...
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Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
... with tumor suppressor ...(RASSF1A) gene is one of the most frequently silenced transcripts in human tumors; however, few studies have simultaneously investigated epigenetic abnormalities associated ...
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A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
... Epithelial malignancies such as colorectal and breast cancer are thought to arise and progress towards malignancy due to alterations in signal transduction pathways that regulate the balance between self-renewal and ...
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Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands
... histological tumor type is an important factor for the survival of affected animals (Sontas et al, ...the gene condition of the tumor tissue and few have addressed the remaining, apparently healthy ...
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DNA methylation analysis of the tumor suppressor gene CDKN2B
... the tumor-cell population, unlike the one that is produced by the genetic changes (Jones and Baylin, ...CDKN2B gene expression was very low when the gene was found to be hemimethyl- ated by MSP ...
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Genetic alterations in head and neck squamous cell carcinomas
... and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and ...include gene amplification and overexpression of oncogenes such as ...
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Avaliação da expressão do gene supressor de tumor PTEN, proto-oncogene c-kit, matrilisina...
... Evaluation of the expression of the tumor suppressor gene PTEN, proto-oncogene c-kit, matrilysin (MMP-7), Connexins 32 and 43 and E- caderinas/cateninas complex in mast cel[r] ...
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Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.
... KLF4 gene was shown to cause a defect in the proliferation and differentiation of gastric mucosal epithelium, it was concluded that a genetic alteration of the KLF4 gene might play a minor role in gastric ...
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Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
... osteoblastic gene expression and cal- cium deposition in vascular smooth muscle cell ...potential tumor suppressor gene in ovarian cancer develop- ...
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O controle epigenético da expressão gênica na carcinogênese mamária: investigação de genes candidatos a supressores tumorais mapeados em 3p21.3
... with tumor suppressor ...(RASSF1A) gene is one of the most frequently silenced transcripts in human tumors, few studies have simultaneously investigated epigenetic abnormalities associated with the ...
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Braz. oral res. vol.26 número3
... of tumor suppressor gene p53, proliferation marker Ki-67, and oncogene c-erbB2 and to evaluate the relevance of their co-expression in the diagnosis of, and prognosis for, oral ...
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VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer.
... this gene can suppress tumor growth and ...TCF19 gene can be considered as coding for a new trans-activating factor that could play an important role in the transcription of genes required for the ...
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Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells.
... Human tumor suppressor gene WWOX encodes the mRNA for translating into WWOX/WOX1, WOX2 and other isoforms (if present) ...a tumor suppressor is ...the tumor suppressor ...
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Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.
... where tumor progression is positively correlated with the expression of MMP ...of tumor suppressor gene ARHI which is target of miR-221/222 ...between tumor cells and vascular ...
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Sao Paulo Med. J. vol.121 número5
... multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic ...tiple tumor-suppressor genes involved in negative regulation of the cell cycle, ...
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Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease
... putative tumor suppressor gene and plays a role in the differentiation of striated cells and remodeling of coronary ...this gene is associated with Marfan syndrome, Loeys-Dietz syndrome, ...
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A new tumor suppressor that regulates tissue architecture.
... tumor suppressor gene, ductal epithelium– associated RING Chromosome 1 (DEAR1) [1], that maps to Chromosome ...inactivated gene in breast ...
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