Tumor suppressor genes
Utility of Serum miR-125b as a Diagnostic and Prognostic Indicator and Its Alliance with a Panel of Tumor Suppressor Genes in Epithelial Ovarian Cancer.
... The development of epithelial ovarian carcinogenesis is a multistep procedure entailing the dysregulation of oncogenes and tumor suppressor genes. Contemporary studies have reported that ...
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High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.
... In brief, plasmid DNAs were purified using R.E.A.L. Prep kit (Qiagen, Valencia, CA). Transfections were performed using LipofectAMINE PLUS Reagent (Life Technologies, Rockville, MD) according to the manufacturer’s ...
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Effect of Regucalcin on the expression of oncogenes and tumor suppressor genes in prostate cell lines
... stromal tumor cells during the different developmental stages of PC notably contribute in enhancing the tumor cell growth, survival, migration and ...
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Lack of evidence for mutations or deletions in the CDKN2Ap16 and CDKN2Bp15 genes of Brazilian neuroblastoma patients
... Two tumor suppressor genes, CDKN2B/p15 and CDKN2A/p16 (cyclin-dependent kinase inhibitors 2B and 2A, respectively), are lo- cated in the 9p21 region and can be targets of inactivation in cases with ...
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Sao Paulo Med. J. vol.121 número5
... analyze tumor suppres- sor genes of the 9p21 region in children with acute lymphoblastic leukemia is available in the ...for tumor suppressor genes inacti- vation, the present findings ...
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Frequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing.
... Several genes commonly found to be mutated in various lung cancers have been reported, including ALK/ELM4 fusion, K-ras, EGFR, VEGF, and p53, yet the entire genetic profile of each form is still not been fully ...
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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
... benign tumor, retinoma, but not enough to drive to malignancy; additional mutational events (M3-Mn) are required for development to retinoblastoma ...and tumor suppressor genes (p75 NTR and ...
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Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.
... several genes and signaling pathways ...where tumor progression is positively correlated with the expression of MMP ...of tumor suppressor gene ARHI which is target of miR-221/222 ...between ...
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Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.
... Cervical cancer is a major contributor to cancer-related death in females worldwide and accounts for 250,000 deaths each year [1]. Although infection with high-risk human papillomaviruses (HPV) is intimately related to ...
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P53 gene: major mutations in neoplasias and anticancer gene therapy
... these genes show recessive behavior (EL-DEIRY, 2003; TESTA & HINO, ...the tumor suppressor gene expression was assigned to genes involved in the control of strategic points of the chain of ...
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Genetic alterations in head and neck squamous cell carcinomas
... and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and ...TP53 tumor suppressor gene ...other tumor suppressor ...
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Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.
... and tumor formation can often be linked to the loss of epithelial cell ...as tumor suppressors, and orthologs of this evolutionary conserved pathway are lost in human carcinoma with high ...these ...
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Avaliação de mutações nos genes supressores de tumor MEN1 e AIP em prolactinomas associados a síndromes familiais
... Pituitary adenomas are benign neoplasms that arise from the expansion of single cells from the adeno-pituitary. These tumors comprise 10 to 15% of all intracranial tumors. The pathogenic mechanisms of these tumors can be ...
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Braz. Dent. J. vol.22 número5
... of genes involved in the cell cycle control have been described in different benign and malignant neoplasms ...in tumor suppressor genes have been reported in epithelial odontogenic tumors ...
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Docking Studies on Anticancer Drugs for Breast Cancer Using Hex
... mutated tumor suppressor genes) to cause cancer cell growth and proliferation Breast cancers that are estrogen and progesterone receptor positive ...
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O controle epigenético da expressão gênica na carcinogênese mamária: investigação de genes candidatos a supressores tumorais mapeados em 3p21.3
... of tumor suppressor genes by epigenetic mechanisms is recognized as an important feature of tumor ...discrete genes, but also could affect consecutive CpG islands in some genomic ...
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VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer.
... upregulated genes and 135 downregulated genes (Table S3). We searched genes that overlapped with cancer-associated and molecular function-related gene sets in MSigDB (C4 and C5 gene sets; ...
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A role for angiogenesis in rheumatoid arthritis
... into the synovium. Similar peptides prevent inflammation in delayed-type hypersensitiv- ity reactions through this mechanism (54). However, it is noteworthy that these linear peptide antagonists have broad specificity, ...
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A new tumor suppressor that regulates tissue architecture.
... tumor suppressor gene, ductal epithelium– associated RING Chromosome 1 (DEAR1) [1], that maps to Chromosome 1p35.1, a re- gion of the chromosome that is associated with loss of heterozygosity in breast and ...
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Expressão de genes de repressão gênica em tumor primário em relação à presença ou...
... de genes é controlado pela desacetilação de histonas e metilação de DNA, esta última catalisada por enzimas DNA metil ...de genes. Logo, nosso objetivo foi determinar no tumor primário de mama, a ...
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