Tumor suppressor protein p53/analysis
Tumor suppressor p53 protein expression : prognostic significance in patients with lowrisk syndrome
... showed p53 expression in their bone ...express p53. Furthermore, patients express- ing p53 had a shorter median survival time compared to those without p53 ...of p53 at diagnosis is a ...
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Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma.
... in tumor cells. One of these proteins, p53, can suppress T-antigen expression through suppression of the viral promoter ...T-antigen protein occurs downstream of alternative splicing ...the ...
10
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
... of protein from each sample using 10 mg of anti-flag antibody. The protein complexes were analyzed on a 6% TBE non-denaturing polyacrylamide gel with a PageRuler Plus pre-stained ladder (Thermo scientific) ...
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Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.
... in tumor cells, we questioned whether loss of Arf in a non-b-cell type could in part be facilitating the angiogenic switch and tumor ...RIP-Tag2 tumor progression without significantly affecting ...
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Structure and stability insights into tumour suppressor p53 evolutionary related proteins.
... Structural stability in Molecular Dynamics Simulations. We performed 30 ns of Molecular Dynamics (MD) simulations on all the studied systems. In Figure 5A the overall root mean square displacement (rmsd) of the C-alpha ...
17
A Bmi1-miRNAs cross-talk modulates chemotherapy response to 5-fluorouracil in breast cancer cells.
... reported p53 could positively regulate miR-200c [27], and here ectopic wild-type p53 expression factually upregulated miR-200c expression in selected cell lines and restored Bmi1 mediated miR-200c ...
10
The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect.
... To assess the permeability across membranes of p53 fusion proteins, H1299 cells incubated with p53, GnRH-p53 and GnRH III-p53 (40 μg/ml) or PBS for 4h were analyzed by immunofluorescence. ...
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Intragenic suppressor of Osiaa23 revealed a conserved tryptophan residue crucial for protein-protein interactions.
... of protein-protein interactions among these transcription factors, the mechanisms involved in these interactions are largely ...Sequence analysis revealed that an amino acid substitution occurred in ...
9
Braz. Dent. J. vol.16 número1
... and p53 protein expressions were analyzed in 16 cases of ameloblastoma and 8 cases of adenomatoid odontogenic tumor ...each tumor was categorized according to the predominant cell ...for ...
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Clinics vol.69 número1
... of protein for each sample were migrated in acrylamide gels and blotted onto nitrocellulose filters, as previously described (29), before incubation with the following mono- clonal antibodies: anti-p53, ...
7
Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor.
... of protein complex is to fractionate the immunopurified protein complex along with a control purification sample by SDS-PAGE, excise the protein bands specific to the protein complex sample, ...
9
The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.
... S1 Fig Decrease or loss of BCL-7 results in a variety of phenotypes, including Egl, Pvl, and Burst in Caenorhabditis elegans. A: A schematic diagram of protein homology of human BCL7 family (hsBCL7A, hsBCL7B, and ...
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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
... Slides selected for analysis were studied using the immunohis- tochemical protocol described previously[12]. Briefly, slides were incubated with primary, then biotinylated secondary antibodies, either anti-mouse, ...
15
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
... Invasive tumor cells in this model were always Lkb1-negative (asterisks, ...LKB1 protein was promi- nently expressed in the apical surface ...endogenous protein in diverse human and mouse tissues, ...
7
Avaliação da expressão imuno-histoquímica das proteínas p53 e pRB em ameloblastomas...
... A fosforilação de pRB por CDK4-ciclina D1 é etapa dependente na progressão das fases G1/S no ciclo celular (Cobrinik, 2005). O eixo p16-ciclina D1-cdk4-Rb pode ser descrito como uma via de relevância central na regulação ...
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Sao Paulo Med. J. vol.115 número1
... gene p53 in 53 percent of cases, dem onstrated by polY lnorphisll1 of single strand ...gene p53 by the polY lnerase chain re£1ction in 63 percent of the cell lines ...gene p53, analyzed by the single ...
7
Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
... Further analysis is required to determine what is occurring in the mutant embryos and whether cell division defects, as observed in the cell lines tested here, are ...
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Expressão da p53 no tumor e no epitélio oral em pacientes com câncer de boca e faringe
... de tumor e superexpressão da p53, indica-nos que possíveis alterações gênicas e moleculares, entre elas da expressão da p53, quando detectadas em indivíduos com carcinomas de boca e faringe, podem ...
7
Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.
... on tumor suppressor miRNAs regulated by genistein and investigated their function in prostate cancer (PCa) and target ...microarray analysis and real-time RT-PCR we observed that miR- 574-3p was ...
12
Expression of p53 protein in pituitary adenomas
... p53 protein was positive in 2/148 pa- tients (1.3%). Immunohistochemistry re- vealed that both adenomas were GH- and PRL-producing. One of the patients was a 35-year-old male with clinical acromegaly and ...
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