[PDF] Top 20 A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.
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A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.
... regulator of cell cycle progression. Deregulation or mutations of CDNK3 have been implicated in various ...the role of CDKN3 in Bcr-Abl-mediated ... See full document
12
Expressão de galectina-1 e -3 na leucemia mielóide crônica e sua contribuição para...
... reported in different tumors and, in some cases this expression was associated to the acquisition of metastatic ...involved in tumorigenesis, including cellular adhesion, proliferation, ... See full document
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Bcl-xL silencing induces alterations in hsa-miR-608 expression and subsequent cell death in A549 and SK-LU1 human lung adenocarcinoma cells.
... significant role in the activation of a number of processes critical for tumorigenesis including inhibition of apoptosis, aberrant cell proliferation, promotion of ... See full document
14
BCR-ABL promotes PTEN downregulation in chronic myeloid leukemia.
... p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as protein ... See full document
4
iNKT Cells Are Responsible for the Apoptotic Reduction of Basophils That Mediate Th2 Immune Responses Elicited by Papain in Mice Following γPGA Stimulation.
... increase in IL12 receptor expression on their surface compared to NK cells (S1 Fig); thus, we next examined whether γPGA activates NKT cells depending on DC-derived IL12, which is essential for NKT cell activation ... See full document
20
Regulação da expressão de SH3BGRL2, D53, PRAME, DAP12 e calcineurina A beta por BCR-ABL...
... células BCR-ABL + à apoptose, o transplante de medula óssea tem sido o único tratamento definitivo para a ...o BCR-ABL é necessário na patogenia da LMC e que sua atividade tirosina-quinase é ... See full document
36
Role of chemerin and its receptors in mouse models of tumorigenesis
... apoptosis in the absence of CCRL2 may be the result of poor vascularization, we observed the expression of several angiogenic factors in ...increase of TSP-1, VEGFA and FGF2 ... See full document
76
Rev. Bras. Hematol. Hemoter. vol.35 número4
... advances in the understanding of this group of hematologic ...important role in the signal transduction of various hematopoietic growth ...results in the substitution ... See full document
2
Estudo das alterações cariotípicas, do rearranjo gênico BCR/ABL e do cromossomo 20 em leucemias
... importance of the cytogenetic analysis in relation to leukemia, its direct benefits to the patients and the biological mechanisms involved in this ...introduction in the Genetic Service ... See full document
2
Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era.
... Different BCR-ABL mutations have prognostic significance and vary in their effects on the sensitivity to standard doses and dose escalations of imatinib and as well as to other TKIs ... See full document
9
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
... (University of Copenhagen, Copenhagen, Denmark) and Professor Chen Degui (Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS) for providing ...course of ... See full document
8
Investigating The Use Of Mobile Computing In Zimbabwe Polytechnics Case Of A Polytechnic In Zimbabwe
... improvement in mobile computing device characteristics since Zimm erman’s research up to ...EDUCAUSE, in his article titled ―Executive Summary: Student Mobile Computing Practices—lessons learned from Qatar‖ ... See full document
5
Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML).
... proliferation in CML cell lines possibly through the activation of BCR-ABL1 and ...light in discovering novel molecular targets for CML treatment, where drug resistance has become a huge ... See full document
9
Rev. Bras. Hematol. Hemoter. vol.33 número6
... 2. Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N, Deininger MW, Silver RT, Goldman JM, Stone RM, Cervantes F, Hochhaus A, Powell BL, Gabrilove JL, Rousselot P, Reiffers J, Cornelissen JJ, ... See full document
6
Leucemia Mielóide Crônica: causas de falha do tratamento com mesilato de imatinibe.
... Katia B. B. Pagnano O mesilato de imatinibe (MI) é atualmente o tratamento de escolha da Leucemoa Mielóide Crônica (LMC), mas, apesar dos excelentes resultados, não é capaz de erradicar completamente a doença, podendo ... See full document
5
ROLE OF DEXMEDETOMIDINE IN ANESTHESIA AND CRITICAL CARE
... uses of dexmedetomidine (DEX), a highly selective α2- adrenoceptor agonist are very diverse Although not orally active, DEX shows good bioavailability when administered via various other routes like intranasal, ... See full document
11
Susceptibility of Ph-positive all to TKI therapy associated with Bcr-Abl rearrangement patterns: a retrospective analysis.
... chemotherapy in combination with TKI treatment which may achieve high CR rate, reduce the drug related side effects, and elevate the tolerance of patients to ...or in combination with TKI therapy may ... See full document
14
Fluorescent in-situ hybridization (FISH) for BCR/ABL in chronic myeloid leukemia after bone marrow transplantation
... the ABL (9q34.1) gene and green dots (fluorescein) to the BCR (22q11) gene, so when one cell with two isolated red and green dots was seen, it was counted as normal, without ...samples of normal ... See full document
3
Rev. Bras. Hematol. Hemoter. vol.30 suppl.2
... kind of resistance they can determine: some mutant clones are completely resistant (Y253F/H, E255K, T315I), others only partially (M244V, F317L, Met351T), depending on whether the bound with the drug following the ... See full document
6
Efeito do veneno bruto e da L-aminoácido oxidase de Bothrops pirajai em células BCR-ABL...
... presence of Philadelphia chromosome (Ph) and molecularly by bcr-abl1 neogene that encodes the BCR-ABL oncoprotein with high tyrosine kinase (TK) ...cell BCR-ABL + presents poor ... See full document
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