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[PDF] Top 20 A novel statistic for genome-wide interaction analysis.

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A novel statistic for genome-wide interaction analysis.

A novel statistic for genome-wide interaction analysis.

... in genome-wide association studies (GWAS) has been made, the significant SNP associations identified by GWAS account for only a few percent of the genetic variance, leading many to question where and how we ... See full document

15

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.

... first novel association, metabomatching allowed the identification of the underlying ...1. Genome- and metabolome-wide analysis results, first ...(B) Genome- and metabolome- wide ... See full document

10

Genome-wide analysis of heteroduplex DNA in mismatch repair-deficient yeast cells reveals novel properties of meiotic recombination pathways.

Genome-wide analysis of heteroduplex DNA in mismatch repair-deficient yeast cells reveals novel properties of meiotic recombination pathways.

... entire genome but the median distance between two COs is not significantly different from the 123 kb observed in a wild type hybrid (p = ...COs genome-wide through the action of ... See full document

18

On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.

On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.

... For genome-wide association studies in family-based designs, we propose a new, universally applicable ...test statistic exploits all available information about the association, while, by virtue of ... See full document

9

Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure.

Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure.

... the genome with a median physical distance between SNPs of ...Affymetrix genome-wide genotyping was performed according to the standard manufacturer’s protocol (GeneChip H Mapping 250 K Assay Manual ... See full document

6

Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome.

Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome.

... functional genome distribution, indicating that the majority of the DMPs are located in inter- genic regions (58%) leading to an over-representation of these regions regarding the design of the 450K infinium array ... See full document

20

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.

... a genome- wide association study of acute oxidative stress resistance to two oxidizing agents, paraquat and menadione sodium ...were novel with no known role in oxidative stress ... See full document

15

Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

... the analysis to the homogeneous set of ...an analysis where association with each skeletal size measurement was assessed after adding height as an additional term to the linear regression ...height-adjusted ... See full document

13

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

... and human PCDH20 gene occurs. 10. In HuH7 cells, rat Hnf4 alpha2 protein increases expression of human APOC1 mRNA. 11. Binding of human AGPAT1 gene and human HNF4A protein occurs. 12. Binding of human HNF4A protein and ... See full document

14

A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.

A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.

... Autophagy is negatively regulated by the TOR kinase which phosphorylates ATG13. Phosphorylated ATG13 is unable to initiate autophagy via the interaction with ATG1 to form the pre- autophagosomal structure [73]. ... See full document

14

Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets.

Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets.

... coelicolor genome by 45 ECF (extracytoplasmic function) sigma factors genes and some 70 two-component regulatory systems ...coelicolor genome sequence— the first from an antibiotic-producing actinomycete ... See full document

24

Genome-wide analysis of long noncoding RNA (lncRNA) expression in hepatoblastoma tissues.

Genome-wide analysis of long noncoding RNA (lncRNA) expression in hepatoblastoma tissues.

... a genome-wide analysis of lncRNA expression in hepatoblastoma tissues to identify novel targets for further study of ...The genome-wide analysis of lncRNA expression in ... See full document

9

Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study.

Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study.

... GWA analysis of LR. However, a sum of 27 chromo- some-wide significant SNPs that located on different chromosomes was ...entire genome SNP variants ...entire genome with small individual ... See full document

20

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.

... Affymetrix Genome- Wide Human SNP Arrays ...the analysis and excluded those SNPs which showed a significant difference of allele frequencies in cases (RLS and unrelated phenotype on ... See full document

10

From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis.

From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis.

... A genome-wide epigenetic analysis of CD14++ CD16- monocytes from critically ill patients with different kinds of inflammatory diseases has a great potential to reveal novel pathophysiological ... See full document

9

Genome-Wide Locations of Potential Epimutations Associated with Environmentally Induced Epigenetic Transgenerational Inheritance of Disease Using a Sequential Machine Learning Prediction Approach.

Genome-Wide Locations of Potential Epimutations Associated with Environmentally Induced Epigenetic Transgenerational Inheritance of Disease Using a Sequential Machine Learning Prediction Approach.

... the novel machine learning approach and predicted genome-wide germ cell DMR used recently identified sperm DMR not used as training data ...predicted genome-wide sperm DMR data set. The ... See full document

25

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.

... Quantigene analysis of U-2 OS cells demonstrated that target gene mRNA levels were reduced to ,15% of the control by all 3 ARCN1 and FUZ siRNAs and for TSPAN9-1 siRNA, while TSPAN9-2 and -3 siRNAs caused ... See full document

10

The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.

The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.

... High-throughput analysis of the ERF data was supported by a joint grant from the Netherlands Organisation for Scientific Research and the Russian Foundation for Basic Research (NWO-RFBR ...data analysis, ... See full document

13

Functional annotation of rheumatoid arthritis and osteoarthritis associated genes by integrative genome-wide gene expression profiling analysis.

Functional annotation of rheumatoid arthritis and osteoarthritis associated genes by integrative genome-wide gene expression profiling analysis.

... This analysis provides a novel insight into the pathophysiological processes involved in these ...develop novel therapeutic strategies in preventing the RA and ... See full document

9

Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis.

Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis.

... in genome-wide association ...genetic-association interaction network (GAIN), whose edges quantify the synergy between variants with respect to the ...simulation analysis to show that EC is ... See full document

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