[PDF] Top 20 Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.
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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.
... kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastro- intestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in ... See full document
11
Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
... (16,28). EGFR-T790M-bearing NSCLCs with acquired resistance to gefitinib or erlotinib do not respond to the second-generation EGFR TKI ... See full document
11
Integrin alpha5beta1 and resistance to cancer therapies: role of endocytosis in resistance to gefitinib
... The EGFR signaling network is critical for tumor progression because it promotes cancer cell survival, growth and ...invasion. In GBM, erbB1 the gene encoding of the ... See full document
106
Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib.
... lines with different mutations (KRAS: H358; PTEN: H1650; T790M: H1975) that render them resistant to EGFR TKIs were further selected for the dual ...targeting. The resistance ... See full document
11
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.
... mutations in genes encoding adaptor proteins or phosphatases that might affect the ERBB signaling ...pathway. Second, WGA could have skewed the results by selectively amplifying DNA ... See full document
8
Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era.
... mutations is not recom- mended in newly diagnosed CP-CML patients [24] because the frequency of mutations in these patients was found to be low in previous studies, these ... See full document
9
MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.
... member of the human epidermal growth factor receptor (HER) family controls key cellular programs, including survival, proliferation, differ- entiation and migration during development and adult life [1, ... See full document
22
J. bras. pneumol. vol.41 número4
... cancer is the leading cause of cancer-related deaths ...from the development of molecular targeted drugs; particularly promising are those blocking the signal transduction ... See full document
11
Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.
... Despite the initial response, all patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) eventually develop acquired resistance to ... See full document
13
Association of vitamin D receptor BsmI gene polymorphism with risk of tuberculosis: a meta-analysis of 15 studies.
... were the source of heterogeneity, which was in consistent with sub-group ...test to explore the source of heterogeneity. The obvious heterogeneity existed in ... See full document
8
INIBIDORES DAS TIROSINACINASES NA TERAPÊUTICA FARMACOLÓGICA
... Efficacy of imatinib in aggressive fibromatosis: Results of a phase II multicenter Sarcoma Alliance for Research through Collaboration (SARC) ...therapy in heavily pretreated HER2-positive ... See full document
19
Clinics vol.67 número7
... According to the new international multidisciplinary classification of lung adenocarcinomas proposed by the International Association for the Study of Lung ... See full document
3
SOCIAL ECONOMY – A FORM OF INCLUSION AND OF ''REACTIVATING'' OF LABOR IN THE CONTEXT OF THE CURRENT CRISIS
... essence of social economy is the inclusive function of the labor market through which the different forms of social economy that exist in the member states ... See full document
13
Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα).
... activation of estrogen receptor (ER) through genomic and non-genomic mechanisms and are implicated in the development of endometrial ...proliferation of human endometrial cancer cells ... See full document
11
An Advancement To The Security Level Through Galois Field In The Existing Password Based Technique Of Hiding Classified Information In Images
... be the password of length „T‟ characters. The password could be of any length and any combination of characters like lower case letters, upper case letters, and special ...characters. ... See full document
6
Distinct Clinicopathological Patterns of Mismatch Repair Status in Colorectal Cancer Stratified by KRAS Mutations.
... between the presence of lymph node metastases and pMMR tumors stratified by KRAS mutation ...tumors with KRAS mutation demonstrated more positive lymph nodes and pTNM III-IV stage ... See full document
12
Repositório Institucional UFC: Status of benzimidazole resistance in intestinal nematode populations of livestock in Brazil: a systematic review
... used in only one study. Coproculture was performed in 33/40 (82.5%) of the studies to identify the nematode genus through morpho- logical analyses of the ... See full document
10
Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility
... 1998), the three European– American cohorts of control individuals presented the highest frequencies, which ranged from ...0.0017 to 0.008. The three Latin cohorts together with ... See full document
12
The Influence of Small Amounts of Aluminium on the Spheroidization of Cast Iron with Cerium Mischmetal
... concerning the data gathered in Tables 4-7 and photographs presenting both the shape, the magnitude, and the distribution of graphite precipitates (Figs 1, 3, 5, 7), as well as ... See full document
6
TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.
... but is more likely to induce its nuclear re-localization that associated with the gain of a mesenchymal ...phenotype. In this model the loss of CDH1 ... See full document
11
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