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[PDF] Top 20 Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells.

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Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells.

Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells.

... Epithelial-mesenchymal transition (EMT) is associated with loss of the cell-cell adhesion molecule E-cadherin and disruption of cell-cell junctions as well as with acquisition of ... See full document

12

MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression.

MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression.

... metastasis in vivo, we utilized xenograft models by injection of MDA-MB-435s cells, with forced expression of miR-7, orthotop- ically in the mammary fat pad of nude ...expression ... See full document

12

Mechanisms of RON-mediated epithelial-mesenchymal transition in MDCK cells through the MAPK pathway

Mechanisms of RON-mediated epithelial-mesenchymal transition in MDCK cells through the MAPK pathway

... the cytoskeleton, and reducing cellular interaction ...expression of RON was accom- panied by tyrosine phosphorylation, which indicated constitutive ...activation of downstream signaling proteins ... See full document

9

1-Methyl-D-tryptophan potentiates TGF-β-induced epithelial-mesenchymal transition in T24 human bladder cancer cells.

1-Methyl-D-tryptophan potentiates TGF-β-induced epithelial-mesenchymal transition in T24 human bladder cancer cells.

... T24 cells by lysis buffer (50 mM Tris- Base, 1 mm EDTA, ...micrograms of total protein were denatured and loaded on a 12% sodium dodecyl sulfate (SDS)-polyacryl- amide electrophoresis gel and then ... See full document

16

Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells.

Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells.

... number of receptor tyrosine kinases [10,11,22]. However, in addition to the established functions in clinical trials, sorafenib likely has much broader effects than is currently ...capacity of ... See full document

9

Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition.

Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition.

... MSCs in inflammation microenvironment were exerting their effects through induction of EMT, a number of specific genetic markers of EMT were examined in HCC ...present in most ... See full document

13

Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer.

Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer.

... study regulation of EMT, PTHrP was stably overexpressed in DU 145, a prostate cancer cell line with low basal PTHrP expression as determined by immunoassay (Figure ...isoform of PTHrP ... See full document

8

Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer.

Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer.

... metastasis in nude mice inoculated intrasplenically with human pancreatic cancer ...effects of QYHJ on primary tumor in the pancreas and on liver ...Tumors in the pancreas were ... See full document

9

Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells.

Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells.

... [45]. In addition, wild type p53 upregulates MDM2 and forms a p53-MDM2-Slug complex to degrade Slug in non-small-cell lung cancer cells, and Slug expression level correlates positively with ... See full document

12

Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma.

Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma.

... detection of the migration and invasion abilities of ACC Ar cells, their morphological transformation from cobblestones to an elongated, spindle-shaped appearance was observed (Figure ...acquisition ... See full document

14

Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells.

Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells.

... cultured cells using RNAfast 200 (Fastagen Biotech ...cycles of 95uC for 5 s and 60 uC for 31 s. Each measurement was performed in triplicate, and no-template controls were included for each ... See full document

12

Afadin downregulation by helicobacter pylori Induces epithelial to mesenchymal transition in gastric cells

Afadin downregulation by helicobacter pylori Induces epithelial to mesenchymal transition in gastric cells

... protein of the adherens junctions, which regulates the formation and stabilization of both the adherens and the tight ...expression of Afadin has been shown in cancer and its loss has ... See full document

13

Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition.

Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition.

... through regulation of EMT ...the metastatic ability and cancer stemness in cancer cells ...best of our knowledge, we are the first to report that Oct4 could ... See full document

8

TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.

TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.

... express mesenchymal markers but ZEB1 could not be linked to this phenotype suggesting that other transcription factors might be ...those epithelial tumors, a subset could have started an EMT ...examination ... See full document

11

Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells.

Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells.

... 603B cells were more resistant to TNF-a/SC-514-induced ...effects of TGF- b1 on 603B cells, suggesting that TGF-b1-induced EMT-like alterations might contribute to cholangiocyte accumulation during ... See full document

12

Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.

Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.

... lung cancer (NSCLC) eventually develop acquired resistance to EGFR tyrosine kinase inhibitors ...half of acquired resistance cases, while MET amplification has been associated with acquired resistance ... See full document

13

Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells.

Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells.

... function of proteins, miR-210 and microtu- bules. Fig 6 is a model of macrophenotypes (angiogenesis, Fe-S cluster biogenesis, cell cycle, glycolysis, epithelial-mesenchymal transition ... See full document

22

Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.

Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.

... a transition process in which epithelial cells acquire mesenchymal ...hallmarks of the EMT can be summarized as the loss of epithelial cells markers such as ... See full document

17

Role of Bmi-1 in regulation of ionizing irradiation-induced epithelial-mesenchymal transition and migration of breast cancer cells.

Role of Bmi-1 in regulation of ionizing irradiation-induced epithelial-mesenchymal transition and migration of breast cancer cells.

... adjuvant cancer treatment, and radiation as a palliative measure for patients with advanced cancer ...involved in radiotherapy-associated side ef- fects have not all been ...role of IR ... See full document

10

MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4.

MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4.

... role of miR-145 in EMT and revealed its molecular ...Oct4 in cancer cells, which in turn regulates the expression and function of ...expression of Snail, ... See full document

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