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Age-related retinopathy in NRF2-deficient mice.
... Microscopy Mice were terminally anesthetized and subjected to whole body perfusion with 4% paraformaldehyde in phosphate-buffered saline ...post-fixed in the same fixative overnight before embedded ... See full document
10
Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins.
... of age and under normal feeding ...and in tolerance tests they are hyporesponsive to insulin but respond normally to ...IfitmDel mice have enhanced levels of serum leptin suggesting a defect ... See full document
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Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
... with age (Fig. 5B), in parallel with the increase of TUNEL-positive hepato- cytes ...with age matched the increase in the number of iron-rich macrophages ...and in the percentage of ... See full document
13
Influence of sex and genetic background on anxiety-related and stress-induced behaviour of prodynorphin-deficient mice.
... KO mice has been described elsewhere [20]. In short, the entire coding sequence of the Pdyn gene was replaced by a basally silent construct Cre-recombinase under Teton ...control. Mice were ... See full document
7
Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse.
... studies in which biopsies have been performed in patients with AIP. In one large population study [4], 16 patients were found with renal impairment with no other cause than ...more in ... See full document
9
A Susceptible Mouse Model for Zika Virus Infection.
... old mice either lacking receptors for IFN-α/β (A129) or from the wild- type strain (129Sv/Ev) were subcutaneously inoculated with 10 6 pfu ZIKV in the lower ...129Sv/Ev mice all survived the 14 day ... See full document
13
Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss.
... Genotyping and immunoblot analyses. All mouse procedures were performed in accordance with McGill University guidelines, which are set by the Canadian Council on Animal Care. Genomic DNA was isolated from tail ... See full document
13
Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice.
... [34]. In this experiment, mice were given intraperitoneal injections of either saline or cocaine (20 ...injections, mice were divided into groups that received seven daily injections of either saline ... See full document
8
EPHA2 polymorphisms and age-related cataract in India.
... found in many people throughout the world as they ...procedure. In low income countries with poor access to cataract surgery, cataract is the main cause of vision impairment and blindness ...[1]. In ... See full document
6
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
... cells in the absence of immunoglobulin in the protective immune response to ...Mtb in the spleen but that excess IL-10 is directly responsible for the increased susceptibility seen in ... See full document
11
Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice.
... (schematized in Figure ...noted in human embryos as ...structures in the region of the lung ...unnoticed in the field due to its German ... See full document
9
Age-Related Shifts in Bacterial Diversity in a Reef Coral.
... observed in 2010 ...declines in physiological performance with age ...on age in numerous higher organ- isms, is the relationship hosts share with their associated ‘natural’ microbiota ... See full document
16
β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype.
... diabetic retinopathy is recognized as the leading cause of blindness in working age adults, we have yet to define the cellular mechanisms responsible for diabetes-induced loss of retinal ...[1]. ... See full document
8
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.
... CD55 in granulocyte homeostasis and anti- bacterial host ...CD55-deficient mice display increased numbers of circulating ...granulocytes in the blood stream, the marginated pool, and the ... See full document
8
Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice.
... FTO deficient mice were characterized by higher heart rate values than wild-type mice, both during the active (dark) and inactive (light) phase of the daily ...temperature in mice ... See full document
10
Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (γ) radiation.
... assessed in this study by determination of circulating vasoconstrictor peptides and plasma nitrite ...shown in Figure 5A–H. In general, a similarity in the patterns of profiles is noticeable ... See full document
10
Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.
... pathway in- volved in cell division, survival and transformation [43], we anticipated that ERK would play a critical role in the development of ICC ...Modifications in gene or protein ... See full document
25
Quantitative changes of nicotinic receptors in the hippocampus of dystrophin-deficient mice
... expressed in striated mus- cles and the central nervous system ...expressed in muscles (Dp427M), throughout the brain (Dp427B), and in cerebellar Purkinje cells ...expressed in the CNS and ... See full document
9
The Vi capsular polysaccharide enables Salmonella enterica serovar typhi to evade microbe-guided neutrophil chemotaxis.
... from mice with C3-deficiency [39]. In serum from C3-deficient mice (bred on a C57BL/6 background), neutrophils from C3-deficient mice did not exhibit a chemotactic response ... See full document
9
Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells.
... only Nrf2 binding elements in which case the activity of reporter plasmid is solely dependent on ...However, in the endogenous cellular setting, target gene expression could be dependent on the ... See full document
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