[PDF] Top 20 The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
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The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
... as the source of AD-associated inflammation ...of the role of Ab in inflammation may now be warranted in view of these data suggesting that the peptide functions as an AMP in ... See full document
10
Computational design of new Peptide inhibitors for amyloid Beta (aβ) aggregation in Alzheimer's disease: application of a novel methodology.
... of the designed peptides is carried out using GOLD Genetic Optimization for Ligand Docking) ...from the Cambridge Crystallographic Data Center, ...a protein binding site to explore the ... See full document
7
MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization.
... form an antiparallel-packed hydrophobic core [19]. Because the electron density of 28 residues in C-terminal tail is low and the residues are mostly hydrophilic, it is believed that ... See full document
7
Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect.
... Amyloid beta (Ab) peptide accumulation in the brains of patients with Alzheimer’s disease (AD) is closely associated with increased nerve cell ...it is important to ... See full document
12
Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering.
... Huntington’s disease is the existence of amyloid deposits in the ...brain[1–6]. Amyloid is gen- erated by abnormal protein aggregation leading to formation of ... See full document
12
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.
... in the pathogenesis of the protein-misfolding neurodegenerative illnesses, especially AD and prion diseases, and possible connections between these diseases have long been contemplated ...diseases ... See full document
8
Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation.
... Alzheimer’s disease (AD) is the presence of amyloid-beta peptide (A ) plaques in the ...A is derived from a sequential proteolysis of the transmenbrane ... See full document
10
Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer’s disease
... Aβ is the major protein constituent of the senile plaques found in the brains of AD patients (Glenner and Wong 1984, Masters et ...ensuing amyloid deposition in the brain ... See full document
20
Cooperativity among short amyloid stretches in long amyloidogenic sequences.
... are associated with many neurodegenerative diseases. Short peptide segments in protein sequences may trigger ...longer protein segments is critical for understanding these diseases and ... See full document
8
Bridging Integrator 1 (BIN1) controls beta-amyloid accumulation in Alzheimer's disease
... of the cytosol in HeLa cells (Chapuis et ...and the Golgi apparatus, ...(EEA1) is a polypeptide required for early endosome fusion (Lawe et ...(TfR) is a protein enriched in recycling ... See full document
88
Apoptosis signaling associated with amyloid β-induced cellular dysfunction and degeneration : relevance for Alzheimer’s disease
... through the JNK pathway. Caspase-2 is an initiator caspase, but specific details of how, where, and when it is activated remain ...Furthermore, the mechanism(s) by which ... See full document
184
Alzheimer disease: development of an immunosensor for amyloid beta detection
... Applying the optimized square-wave voltammetric parameters (frequency 100 Hz, pulse amplitude 40 mV and scan increment 4 mV), calibration data were attained for Aβ42 concentrations ranging from ...38-39). ... See full document
85
Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta.
... tune the balance between the transcriptome and proteome of the ...and disease. In neurodegenerative disorders such as Alzheimer’s disease (AD), brain miRNA profiles are altered; thus ... See full document
11
Amyloid-based nanosensors and nanodevices
... it is very likely that the amyloid structure provides an important structural feature in the morphogenesis of a ...species. Peptide hormones are for example stored in secretory ... See full document
20
Arq. NeuroPsiquiatr. vol.72 número3
... with the purpose of verifying the normality and homoscedasticity, ...baseline, the differences between groups were assessed by an independent sample t-test (educational level, MMSE, CAMCOG, ... See full document
7
Analogues of the antimicrobial peptide BP214
... by the amino acid alanine, preserving the same D-amino acid configuration as ...glycine is the simplest amino acid, it is very flexible and would disrupt the formation of ... See full document
69
Avaliação da Anexina A1, FPR1, FPR2 e miRNAs em adenocarcinoma gástrico
... and protein expression of AnxA1 and Galectin-1 during the progression cascade of gastric cancer, as chronic gastritis, intestinal metaplasia, gastric ulcer and gastric adenocarcinoma [19, ...found ... See full document
107
Auxinic herbicides, mechanisms of action, and weed resistance: A look into recent
... at the plasma membrane also activates a Rho-like small G protein called RAC/ROP ...to the energy-storing molecules similar to ATP [guanine triphosphate (GTP) and guanine diphosphate ...in the ... See full document
7
Analogues of the antimicrobial peptide BP214
... of the most concerning health problems present in the twenty-first century is antibiotic-resistant ...infections. The growing number of multi-resistant infections has led to complicated public ... See full document
56
Rev. Assoc. Med. Bras. vol.43 número1
... Evidentemente, essas descobertas foram extre- mamente importantes, porém não ofereciam uma explicação plausível para os casos de DA esporádicos e de início tardio (que constituem a grande maioria dos casos). Esse estado ... See full document
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