[PDF] Top 20 Assessing the impact of alternative splicing in cancer
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Assessing the impact of alternative splicing in cancer
... use the specific domain problem of assessing the impact of alternative splicing in cancer as a use and test case by automating the full process ... See full document
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A Computational Platform for Assessing the Impact of Alternative Splicing in Cancer
... common in molecular biology to have tasks that are frequently done and are composed by a set of steps (a ...extension of the proposed web interface is an interface where a computer scientist ... See full document
82
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
... plated in a monolayer in contact with other cells, while mesenchymal HMLE/pBP-Twist cell movement is attenuated by cell-cell contact ...with the equivalent unlabeled cell types such that the ... See full document
21
Impact of Telegenetics and Alternative Models of Care on Hereditary Cancer Genetic Counseling in British Columbia
... Triage of groups of patients most suited to this mode of service delivery can be implemented using guidelines such as those with less complex indications and current health status as well as referral ... See full document
21
Analysis of the contribution of alternative splicing to glioma subtype definition
... Particularly, in what concerns alterations in splicing factors, whereas among the list of genes considered to be differentially expressed these were 41, among the differentially ... See full document
114
Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.
... Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional ...Abnormal alternative splicing has ... See full document
13
Signaling Pathways Driving Aberrant Splicing in Cancer Cells
... Activation of the small GTPase RAS with subsequent stimulation of a cascade of three mitogen-activated protein kinases (MAPK, namely RAF, MEK and ERK), is a key event in the ... See full document
17
A statistical method for the detection of alternative splicing using RNA-seq.
... shown in Figure S2 and Table S1, non-specific mapping to exon junctions is a big problem for ...RNA-seq. In mouse dataset, 4,102,511 reads were mapped to ESJ, while 929,756 reads were mapped to negative ... See full document
8
Reciprocal regulation between alternative splicing and the DNA damage response
... affects the expression of nearly the entire genome, and factors involved in every as- pect of the DDR are not the ...Members of the p53, Mdm, bcl-2, or ... See full document
6
A general definition and nomenclature for alternative splicing events.
... Understanding the molecular mechanisms responsible for the regulation of the transcriptome present in eukaryotic cells is one of the most challenging tasks in ... See full document
14
A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.
... knock-down of Srrm4 has an obvious effect on both neural differentiation [28] and hair-cell development (Figure ...greater impact on neural differentiation in zebrafish than in mice? One ... See full document
17
Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells.
... gain the initial insight into potential mechanisms of a1 sGC splicing regulation, we performed in silico analysis using several bioinformatics tools ...[24]. The C-a1 splice variant is ... See full document
9
The impact of neuropathic pain in sleep quality of breast cancer patients
... beginning cancer treatment. Specifically, results from the former demonstrated that three out of five patients presented poor sleep quality at baseline and the latter showed that two of ... See full document
135
Regulation of the alternative splicing of RAC1b in tumour cells
... member of a subfamily of ubiquitously expressed hnRNPs and contains four RNA recognition motif (RRM) domains that bind to the polypyrimidine track of mRNAs introns (Oberstrass ...between ... See full document
64
Assessing the impact of alternative splicing in thyroid cancer
... data, the back-end module will expose an API, via Python with Django, to allow submitting and monitoring ...pool of worker processes in order to allow running multiple tasks at ...stored in ... See full document
77
Bioinformatics application for analysis and visualisation of alternative splicing in cancer
... de splicing alternativo a partir de grandes con- juntos de dados transcript´omicos provenientes do projecto The Cancer Genome Atlas ...de splicing alternativo ...de splicing alternativo ... See full document
105
A new twist to ibuprofen: alternative action in alternative splicing
... differ in their gene expression programme from their corresponding differentiated normal ...promoters, the past 15 years have clearly revealed that alternative splicing serves as a significant ... See full document
8
Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.
... set of such elements, tested in various standard splicing contexts, ESE and ESS elements are currently the best characterized ...interactions. The family of nuclear heterogeneous ... See full document
10
Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless.
... for the idea of a direct connec- tion between pre-mRNA splicing and eye development being conserved from Drosophila to mammals ...As in vertebrates, where the single Pax6 gene produces ... See full document
10
Footprints in the text: assessing the impact of translation on Portuguese historiographical discourse
... 245 7499h 42 ZEHLHIFRIFQIfHLHG[IWMSQRSGmIUMLREHLUInTLFWSIWMUUHWRQIRMIREHIjHOFRHLLSUHSU WMfNGHi\.[r] ... See full document
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