[PDF] Top 20 Association between common lipid metabolism genes polymorphisms and sporadic colorectal adenocarcinoma risk

... apoptosis and improves migrating behavior of cells by promoting their ability to invade adjacent tissues and/or metastasize to non-adjacent organs and ...Aberrant lipid metabolism is a ... See full document

... of colorectal cancer (CRC) is the result of a complex interaction of variables, including external factors such as exposure to environmental agents and dietary factors and internal factors, whether ... See full document

... dysplasia, and other 767 cases of patients who under- went l exible rectosigmoidoscopy with more than 90% of the colorectal mucosa located 50 cm above the anal border visible to the device without ... See full document

... rare and/or of ‘uncertain pathogenicity’ (35). MUTYH Gln335His is a common polymorphism located on exon 12 (35), more frequently detected in Japanese and Chinese than in European ...(38) and ... See full document

... sensor and chaperone of ...levels and contributes to AD with similar genetic risk effects in both the Asian and Caucasian ...reduced risk in AD development and better cognitive ... See full document

... (ORs) and 95% confidence intervals (95% CIs) of TLR2 (2196 to 2174 del) and TLR4 (rs4986790 and rs4986791) polymorphisms and cancer risk were estimated for each ...types ... See full document

... target genes, but have neglected the abnormal expression and functions of miRNA ...miRNA genes arise from discrete independent transcription units that are not located near to their target ...miRNA ... See full document

... relationship between variables of the lipid profile con- firmed the presence of reduced levels of TC, LDL-C, VLDL- C, and TG as a whole in CRC, with an association among the variables ... See full document

... significant association of the G variant with an increased risk of not only gliomas (OR, ...1.48) and oligodendroglial tumors (OR, ...increased risk for glioma and glioblastoma ... See full document

... hyperandrogenemia, and polycystic ovaries morphology [1]. Patients who had diabetes, and congenital adrenal hyperplasia, Cushing syn- drome, androgen-secreting tumors, hyperprolactinemia, thyroid disorders, ... See full document

... whether lipid ratios and TG are associated with IR in Chinese individuals, logis- tic regression models were used and odds ratios (ORs) and 95% confidence interval (CI) were ...calculated. ... See full document

... susceptibility and disease outcome [6, 7, ...[4] and lung cancer risk [27], but not associated with breast cancer [10] and CRC ...genotype and A allele are associated with risk ... See full document

... Pickering and colleagues have initially suggested that hyperten- sion and blood pressure are complex traits [33], and previous epidemiologic studies have found dozens of risk factors, such as ... See full document

... search and data collection were performed using a search protocol with the following criteria: subject interest, inclusion criteria, search strategy and data selection, analysis and results ... See full document

... group, and 245 women were included in the control group. The clinical and epidemiological characteristics of both groups are de- scribed in ►Table ...women and/or women who used hormone therapy in ... See full document

... expression and activity of the ABCB1 transporter may differ between individuals, due to either genetic polymorphisms or pathological conditions [24] and, as a result, this might be reflected ... See full document

... of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these ...an ... See full document

... the risk factors tend to increase significantly with ...IDF and NCEP criteria and determining its relation to Framingham Risk Score ...TCLE and were interviewed, as well as physical ... See full document

... into lipid rafts, and thus it is unknown whether they would be affected functional by our lipid raft depletion ...mechano-transducers and/or other calcium channels potentially involved in ... See full document

... increased risk association for CRC development in Asiatic adults, although this was not noticed in all individual studies ...(B350) and as the frequency of this polymorphism is very low in Asiatic ... See full document