[PDF] Top 20 Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks.
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Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks.
... knowledge of bacterial and yeast GRNs is fairly comprehensive, human GRNs have only been partially ...a core human GRN interconnecting 475 TFs was reported separately for 41 different tissue ... See full document
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Systematic identification of core transcription factors mediating dysregulated links bridging inflammatory bowel diseases and colorectal cancer.
... factor-mediated regulatory networks serve as a decision-making system within mammal cells ...identify core TFs functioning through regulating adjacent dysregulated genes bridging UC and ... See full document
12
Global properties and functional complexity of human gene regulatory variation.
... majority of cases, human disease and complex trait association studies do not identify plausible coding variants implicating a single ...hoc identification of the causal gene(s) that ... See full document
8
Evolution of gene regulatory networks by fluctuating selection and intrinsic constraints.
... effects of mutations on phenotypes and fitness To analyze mutational robustness and evolvability, we used the phenotypic effects of mutations rather than fitness ...effects of mutations can be ... See full document
22
Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria
... scientists in different fields in the construction of large protein-protein interaction networks (Wallach et ...2014). Networks generated from these studies serve to identify potential ... See full document
18
Learning transcriptional regulatory relationships using sparse graphical models.
... function of transcriptional regulatory networks by analyzing high-throughput gene expression profiles is a key problem in computational ...challenges in this work are 1) the lack ... See full document
7
Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii).
... group of jawed vertebrates (Gnathostomes) that diverged from bony vertebrates (Osteichthyes) approximately 450 million years (My) ago ...virtue of their phylogenetic position, cartilaginous fishes are a ... See full document
15
Influence of the experimental design of gene expression studies on the inference of gene regulatory networks: environmental factors
... infer gene regulatory networks from expression data is very challenging and depends on (A) the time point when data are measured, (B) the kind of the external stimulation and (C) the ... See full document
20
Inference of gene regulatory networks with sparse structural equation models exploiting genetic perturbations.
... with gene expression data not only improves accuracy of regulatory network topology inference, but also enables learning of causal regulatory relations between ...number of ... See full document
13
Genome-wide identification of regulatory elements and reconstruction of gene regulatory networks of the green alga Chlamydomonas reinhardtii under carbon deprivation.
... some of the FAIRE peaks were located at larger distances, up to thousands of base-pairs away from the next annotated open reading ...distribution of the FAIRE summits and the corresponding distances ... See full document
16
Mutational robustness of gene regulatory networks.
... mutations of network structure. The results of our analysis provide several clues towards such ...investigate in detail the mechanistic aspects of why certain types of networks ... See full document
9
Quantitative dynamic modelling of the gene regulatory network controlling adipogenesis.
... Gene regulatory networks (GRNs) coherently coordinate the expressions of genes and control the behaviors of cellular ...complexity in modeling a quantitative GRN usually ... See full document
12
Beatriz Fonseca de Oliveira Dias
... evaluation of exon- intron structures indicate that the gene duplication, which led to distinct subfamilies of DEF- and GLO-like genes, oc- curred in the lineage that gave rise to ... See full document
10
Evaluation of gene association methods for coexpression network construction and biological knowledge discovery.
... Genes in the same biological pathway are more likely to be coordinated or co-expressed in order to ensure the co-occurrence of an array of biochemical reactions in response to an ... See full document
17
Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development.
... pathogenesis of inflammatory bowel disease ...implicated in the reg- ulation of IBD through mediating recruitment of T cells to inflamed ...role of CCR9 in inducing and ... See full document
16
A single enhancer regulating the differential expression of duplicated red-sensitive opsin genes in zebrafish.
... patterns of gene expression were recapitulated by fluorescent reporters for both LWS-1 and LWS-2 in the adult retina of ...pattern of LWS-1 was also recapitulated in ...that ... See full document
10
Arq Bras Endocrinol Metab vol.46 número4
... and human D2 mRNA are ...band of the rat D2 mRNA appears as a doublet in different brain regions but not in ...difference in size between the 2 bands is ~500-1000bp ...present in ... See full document
10
Metabolic constraint-based refinement of transcriptional regulatory networks.
... relevance of the interactions retained by GEMINI is also supported by the enrichment for biological processes relevant to the set of target genes for each ...(target genes for each regulator) ... See full document
14
Functional alignment of regulatory networks: a study of temperate phages.
... the regulatory networks of two well-characterized temperate bacteriophages of ...classes of temperate bacteriophages: the lambdoid phages— which include k, P22, 434, HK97, and HK022, ... See full document
5
In vivo SPECT reporter gene imaging of regulatory T cells.
... helped in dissecting some of the mechanisms of action of Tregs [26] these include: 1) the importance of Treg-DC interaction for Treg function [27], 2) the relevance of sequential ... See full document
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