[PDF] Top 20 The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes

... B-1 lymphocytes are known to increase the metastatic potential of B16F10 melanoma cells via the extracellular signal-regulated kinase (ERK) ...Since ... See full document

... In the present study, we demonstrate that phagocytes derived from B-1 cells (called B- 1CDP) have the ability to phagocytose the pathogenic protozoan parasite ... See full document

... cavity of IL-10 knockout mice. As shown in Figure 6a, IL-10 was present in the supernatant of B-1 cultures from wild-type mice ... See full document

... determinants of this process and decreasing antigen availability, as occurs during treatment, generally helps the exhausted T-cell population regain their functional phenotype 86,87 ...T cells have ... See full document

... levels of anti-double stranded DNA (dsDNA) titer, serum complements C3 and C4 levels were performed at study ...level of anti-dsDNA was measured by in house ELISA using a calibration curve ... See full document

... 1 – Desenho do estudo e objetivo(s): Estas informações estão sendo fornecidas para sua participação voluntária como controle (sem deficiência imunológica) neste estudo, cujo objetivo é avaliar a frequência de ... See full document

... consisting of an equal volume of complete Freund’s adjuvant (CFA) and PBS containing 4 mg/ml of heat- killed Mycobacterium Tuberculosis (both from Difco) at the base of the ...ng ... See full document

... percentage of induced CD25 hi Foxp3 hi and CD25 hi Foxp3 int CD4 T cells was dependent on the amount of iRBC added to the culture and increased with rising iRBC:PBMC ratios (Figure 1D; ... See full document

... evaluated the importance of MAPKs on cytokine secretion during interaction of A549 cells with live ...yeasts. In this case, none of the inhibitors (PD98059, SB203580 and ... See full document

... enhancement of binding higher than 6-fold in the best case with respect to the lead ...M1. The maximal binding enhancement was obtained for M5 and M6, which showed binding affinities ... See full document

... Quantification of fungal morphotypes in the tissue lesions showed that both conidia and hyphae were able to turn into muriform cells (Fig 2A, 2B and 2D, red ...hyphae in the ... See full document

... changes in the expression of zinc-related molecules such as zinc transporters and metallothioneins ...[6,7]. In contrast, EZS occurs minutes after an extracellular stimulus and does not ... See full document

... with the metastatic ability of cutaneous melanoma represent a major public health ...Cutaneous melanoma is one of the most invasive human cancers, but the molecular ... See full document

... 1E). IL-17A-treated DC still expressed the CD1a DC marker at 48 h, but also acquired macrophage (CD14/ CD68) ...markers. The intensity of HLA-DR remained unchanged, while the CD40 ... See full document

... Frequency of cells producing TNF-α and IL-1β, and amount of cytokine expressed per cell. 621[r] ... See full document

... types of cells (6 x 10 3 ) were incubated for 24 or 48 h in 96-well microtiter cell culture plates, in the absence (control cells) or presence of UDG, in a ... See full document

... = 10) or recombinant IL-10 (βng/ml; BD Pharmingen) before performing the ...For the phagocytosis assay, green fluorescent protein (GFP)-producing Bb Bγ1 were added to each well at a MOI ... See full document

... concern of immunomodulatory or tolerogenic therapeutic strategies is their long-term impact on the overall immune ...assessed the immune competence of anti- CD4-treated BALB/c mice ... See full document

... A20 is required for termina- tion of Toll-like receptor-mediated immune responses, which protected mice from endotoxic shock ...[26]. In A20-deficient mice, MyD88-dependent TLR signals drive ... See full document

... protists of the human and bovine urogenital tracts, ...described the cytotoxic effects of trichomonads on urogenital tract epithelial ...little is known about the host cell ... See full document