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[PDF] Top 20 B cells at the crossroad of immune responses : insights from primary B-cell immunodeficiencies

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B cells at the crossroad of immune responses : insights from primary B-cell immunodeficiencies

B cells at the crossroad of immune responses : insights from primary B-cell immunodeficiencies

... to the expression of phenotypic markers, such as CD21 and IgD, with T1 cells being IgM bright CD21 - IgD - and T2 cells defined IgM bright CD21 bright IgD bright ...Transitional B ... See full document

216

To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.

To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.

... [12–17]. At the molecular level, it has been demonstrated that retinoic acid opens up the FoxP3 promoter tertiary structure for activated FoxP3 transcription ...and b [19], which are critical ... See full document

13

Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.

Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.

... determine the kinetics of donor-specific T cell reactivity after LTx, we quantified PF of donor-specific T cells in PBMC of 13 LTx-recipients with stable graft function at ... See full document

12

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.

... to the principles of the Declaration of ...blood of 3 healthy donors, whose written informed consent had been provided, was obtained from the Sanquin Blood Bank, Nijmegen, ... See full document

17

Human herpesvirus-8 infection leads to expansion of the preimmune/natural effector B cell compartment.

Human herpesvirus-8 infection leads to expansion of the preimmune/natural effector B cell compartment.

... explain the effects of HHV-8 on B ...perturb the homeostasis of B lymphocytes through anti-apoptotic viral proteins, cytokines or other soluble mediators able to affect ... See full document

10

A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis.

A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis.

... in the regulation of experi- mental autoimmune encephalomyelitis (EAE) and in the suppression of intestinal inflamma- tion in murine models via IL-10, which has strong anti-inflammatory ... See full document

15

Humoral Immune Response in Tuberculous Pleuritis

Humoral Immune Response in Tuberculous Pleuritis

... understand the local and protective immune response against tuberculosis, due to the self-limitedness of the ...Although the cellular immune response has been well ... See full document

6

Impact of IL-10 and SIRT2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections

Impact of IL-10 and SIRT2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections

... control of M. tuberculosis infection requires the activation of specific CD4 T cells in lymph ...These cells migrate to the site of infection where they activate ... See full document

108

Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.

Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.

... obtained from patients undergoing tonsillectomy. Tonsillar B cells were isolated by density fractionation on discontinuous Lymphoprep (Axis-Shield PoC AS, Norway) and Per- coll (Sigma, USA) gradients ... See full document

20

Uveal melanoma cells utilize a novel route for transendothelial migration.

Uveal melanoma cells utilize a novel route for transendothelial migration.

... When immune cells cross the endothelium, immune-cell integrins bind to ICAM1 on the surface of the EC ...UM cells do not express the beta2 integrins ... See full document

16

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.

... although the decrease was not to the same extent as GRK2 WT ...and B). We also examined the effect of GRK2-K220R on GPR3 localization using ...overexpression of GRK-K220R by ... See full document

13

Vildagliptin Ameliorates Oxidative Stress and Pancreatic Beta Cell Destruction in Type 1 Diabetic Rats

Vildagliptin Ameliorates Oxidative Stress and Pancreatic Beta Cell Destruction in Type 1 Diabetic Rats

... increasing the effective concentration of these peptides that reaches the target tissues ...for the treatment of type 2 diabetes, but little is known about the potential benefits ... See full document

9

PKC-Dependent GlyT1 Ubiquitination Occurs Independent of Phosphorylation: Inespecificity in Lysine Selection for Ubiquitination.

PKC-Dependent GlyT1 Ubiquitination Occurs Independent of Phosphorylation: Inespecificity in Lysine Selection for Ubiquitination.

... tion of the dopamine and glutamate transporters and that removal of ubiquitin-conjugating sites abolished these processes ...allow the delivery of previously synthesized transporter to ... See full document

24

Variability of barley aleurone layer induced by X-rays

Variability of barley aleurone layer induced by X-rays

... X-irradiation of plants appeared to be as a successful tool in the research of development of grass ...on the development of endosperm in grass hybrids can improve our ... See full document

3

Immune suppressive effect of cinnamaldehyde due to inhibition of proliferation and induction of apoptosis in immune cells: implications in cancer.

Immune suppressive effect of cinnamaldehyde due to inhibition of proliferation and induction of apoptosis in immune cells: implications in cancer.

... on the immune- suppressive qualities of cinnamaldehyde by investigating its impact on cytokine secretion in primary PBMCs activated with ...suppression of the NF-kB pathway, we ... See full document

7

PP4 is essential for germinal center formation and class switch recombination in mice.

PP4 is essential for germinal center formation and class switch recombination in mice.

... important B cell-intrinsic function for PP4 in GC ...TNP-KLH, the formation of GCs was not observed in the lymphoid follicles of these ...that the severe reduction in ... See full document

16

KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation.

KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation.

... to the family of Kru¨ppel-like transcription factors that bind to GC-rich DNA domains via three C-terminal zinc fingers and controls prolifer- ation and terminal differentiation of various ... See full document

8

Investigating B Cell Development, Natural and Primary Antibody Responses in Ly-6A/Sca-1 Deficient Mice.

Investigating B Cell Development, Natural and Primary Antibody Responses in Ly-6A/Sca-1 Deficient Mice.

... peritoneal B-2 cells in older female Ly-6A/Sca-1 deficient mice when compared to the wild-type, age and sex-matched wild-type mice ...T cells present in peritoneal washing, identified by their ... See full document

21

Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells.

Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells.

... staining, cells were washed in staining buffer (2% FBS, ...dead cell exclusion. Cells were then washed and incubated with purified anti-mouse CD16/32 (Fc-block, eBiosciences) for 10 min on ice, ... See full document

13

Activity deprivation induces neuronal cell death: mediation by tissue-type plasminogen activator.

Activity deprivation induces neuronal cell death: mediation by tissue-type plasminogen activator.

... or the protective effect of its endogenous inhibitor PAI-1 when secreted from astrocytes ...reinforces the proposed involvement of tPA in neuronal death cascades, and also provides ... See full document

5

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