[PDF] Top 20 Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review.

... choice of the statistical tools for analyses was an important ...intention of this analysis was to test the performance of published prognostic signatures in independent datasets rather ... See full document

... limitations in this meta-analysis. On the one hand, due to the clinical value of miR-92a has been explored in CRC only for recent year, small sample size is contained in our ... See full document

... located in the first exon of CXorf1 gene is hypomethylated in stage ...is in accordance with survival analysis performed, which showed that low methylation levels are associated with a ... See full document

... Colorectal cancer (CRC) is a heterogeneous disease with a high mortality rate and is still lacking an effective ...robust prognosis model for predicting the prognosis in CRC ... See full document

... Identification of the molecular characteristics of the tumor microenvironment and elucidation of its crosstalk with tumor cells may therefore be crucial for improving our understanding of the ... See full document

... was in accor- dance with the survival analysis from PrognoScan (Fig ...Combination of the gene expression from Oncomine and survival from PrognoScan revealed the oncogenic role of ACSL4 ... See full document

... roles in cell prolifer- ation, migration, and apoptosis; however, whether VGCCs regulate the onset and progres- sion of cancer is still under ...consists of five members, which are L-type, ... See full document

... FGFR gene has drawn much interest for developing specific inhibitors such as the multiple target inhibitors dovitinib, Ki23057, and ponatinib, and the highly selective inhibitors AZD4547 and ...efficacy of ... See full document

... types of solid cancers, especially for CRC ...risk of CRC compared with normal weight individuals ...involvement of insulin and IGF-1 in colorectal carcinogenesis has been supported by ... See full document

... and clinical implications of HER2 status in primary colorectal cancer ...investigated in two retrospective cohorts of 365 consecutive CRC patients (cohort 1) and 174 ... See full document

... metastasis of CRC, which was consistent with the conclusions of most included ...status of CRC metastasis at the time of diagnosis. The expression of MUC1 in CRC tis- sue ... See full document

... interpretation of the prognostic value of published breast cancer signatures, but has no bearing on their usefulness in the clinic: a marker may be accurate without yielding ... See full document

... surface expression of CD166 would be a positive prognostic marker and that the shedding of CD166, in other words, cytoplasmic CD166 expression would predict the reverse outcome, but ... See full document

... abstract of one paper, in which the authors stated that they had used tissue microarray and immunohistochemistry (IHC) to detect the expression of 31 molecular markers in patients with ... See full document

... prediction of recurrence or disease relapse and the sample collected for the prior purposes can be submitted to gene mutation detection, making ccfDNA a broad disease management ...diagnostic value ... See full document

... Patients in Cluster 1 present a better survival rate, when compared with patients in cluster 2, who have a lower survival rate and a worse ...number of patients that have not reached the terminal ... See full document

... quality of currently available data. Although the performance of the NetWalker algorithm has been demonstrated to be robust against false positive and false negative interactions in the ... See full document

... ALDH1 expression of stage III rectal cancer shows a more aggressive feature and can be stratified into different survival groups ...rectal cancer patients in stage II–III after treating ... See full document

... especially in melanoma generated a tremendous research effort to block this signaling pathway for cancer ...usage of most available multi-kinase inhibitor at that time, sorafenib, was the first step ... See full document

... Besides cancer cells themselves, a tumor comprises stromal ...interactions of stromal and cancer cells is thought to be a major determinant of the tumor behavior and response to therapy [3, ... See full document