each other, indicating that it is possible to use only one of them to identify genotypes with dynamic stability. However, in the static sense, the choice should be made between one ofthe following parameters: PPW, WRW, ERd, TAλ, HUS1 and HUS2, AMMI, and PC2. As for adaptability, the choice should be between: ERb, FWb and TAb, SBb1 and SBb12, CRb1 and CRb12, and SVb1 and SVb12. As to the rank parameter, obtained with the GGE method, it refers to the ideal genotype (high production average and high stability) and is associated with LBPg, LBPd, LBPf, ANWg, ANWd, ANWf, SVmg, SVmd, and SVmf. This indicates that these methods measure simultaneously for yield and stability.
3) Фінансова стійкість. Коефіцієнти даної групи надають безпосередню характеристику стійкості підпри- ємства до різних негативних екзогенних і ендогенних фак- торів. З даної групи має розглядатися коефіцієнт фінансо- вого важеля (DFL – degree of fіnancіal leverage), що описує принципи залучення капіталу. Чим більше позикового капіталу, тим вище даний коефіцієнт, а виходить, шанси нарощування прибутку зростають, оскільки на рішення саме цієї задачі спрямована дія фінансового важеля ком- панії. Одночасно може зростати і ризик неплатежу:
Objective: To determine and to analyze the theoretical and practical knowledge of Nursing professionals on indirect blood pressure measurement. Methods: This cross-sectional study included 31 professionals of a coronary care unit (86% ofthe Nursing staff in the unit). Of these, 38.7% of professionals were nurses and 61.3% nurse technicians. A validated questionnaire was used to theoretical evaluation and for practice assessment the auscultatory technique was applied in a simulation environment, under a non-participant observation. Results: To the theoretical knowledge ofthe stages of preparation of patient and environment, 12.9% mentioned 5-minute of rest, 48.4% checked calibration, and 29.0% chose adequate cuff width. A total of 64.5% of professionals avoided rounding values, and 22.6% mentioned the 6-month deadline period for the equipment calibration. On average, in practice assessment, 65% ofthe steps were followed. Lacks in knowledge were primary concerning lack of checking the device calibration and stethoscope, measurement of arm circumference to choose the cuff size, and the record of arm used in blood pressure measurement. Conclusion: Knowledge was poor and had disparities between theory and practice with evidence of steps taken without proper awareness and lack of consideration of important knowledge during implementation of blood pressure measurement. Educational and operational interventions should be applied systematically with institutional involvement to ensure safe care with reliable values.
by exercise and challenge testing, and has been shown to have beneicial effects on the contraction ofthe diaphragm, an effect which may be particularly useful in patients with COPD (Kidney et al. , 1990; Mak, 1997). Drug-drug inter- actions occur when one therapeutic agent either alters the concentration (pharmacokinetic interactions) or the bio- logical effect (pharmacodynamic interactions) of another agent (Leucuta, Vlase, 2006). The clinical signiicance of a speciic drug-drug interaction depends on the degree of accumulation ofthe substrate and the therapeutic window ofthe substrate (Bachmann, Lewis, 2005). The combination of theophylline and ketotifen is often used in respiratory tract infections and some have suggested that the combi- nation is effective (Benjamin et al., 1994), while others have postulated that the combination may be embryotoxic, leading to growth retardation and morphological abnormali- ties (Bechter, Schön, 1988). The major goal ofthe present study was to elucidate the possible importance of drug-drug interactions (DDIs) as a contributing factor towards drug safety and inally to observe and determine thestabilityofthe complexes which could be formed by the interaction of ketotifen fumarate with anhydrous theophylline in aqueous media at variable pH. The values ofthestability constants of theophylline with ketotifen were determined using Job’s continuous-variation analysis and Ardon’s spectropho- tomeric measurement methods. However, following the interaction of theophylline with ketotifen, stability constants ranged between 0.4-2.0 at pH 1.2 and 4.12 at pH. 6. The sta- bility constant values indicate that co-administration of both drugs may reduce the pharmacological effect ofthe drugs.
Due to difficulties present during machining operations and with segregation of crystals of primary silicon, hypereutectic silumins can be used after modification only. It is why elaboration of effective modification methods is necessary for complete utilization of such alloys for machinery parts made from castings. In the paper are presented test results concerning an effect of modification with phosphor copper and strontium of AlSi21CuNi silumin on change of its mechanical properties (R B m B , A B 5 B ) and its structure. Investigated alloy was melted in
The Popov criterion is considered as one ofthe most ap- propriate criteria for nonlinear systems and it can be com- pared with the Nyquist criterion for linear systems . However there are reservations that relate to the very es- sence, correctness and reliability ofthe criterion. It is nec- essary to emphasise that this criterion is reliable, but the conditions of its appl. should be clearly specified in advance. Table II: Lyapunov´s functions for second-order systems
Developing of a country in both economic and social areas and maintaining of this development are related to a generation that is trained with a quality education. Reaching contemporary civilization level is only possible with teachers implementing their tasks in a real effective way. In education-teaching process, an important feature which teachers need to have is to possess adequate assessment knowledge and put it into practice. Therefore, assessment has an important role in teaching process. Because, assessment provides feedback for teacher about students’ learning in the education-teaching process. The primary education curriculum which was renewed in 2004, is based on constructivist approach. Constructivist approach emphasizes on learning and teaching strategies focusing on student and it takes personal differences into consideration. In this approach, new information that is taken by
Our results show that a small modification ofthe long-range interaction term in the potential energy function of STeM had an important positive impact on the model. This small change improves the method in comparison to existing NMA methods in the traditional areas such as the prediction of b-factors and conformational sampling (overlap) where coarse-grained normal mode analysis are applied. More importantly however, it opens an entire new area of application to coarse-grained normal mode analysis methods. Specifically ENCoM is the first coarse-grained normal-mode analysis method that permits to take in consider- ation the specific sequence ofthe protein in addition to the geometry. This is introduced through a modification in the long- range interactions to account for types of atoms in contact modulated by their surface in contact. As a validation ofthe approach we explored the ability ofthe method to predict the effect of mutations in protein stability. In doing so we created the first entropy-based methodology to predict the effect of mutations on the thermodynamic stabilityof proteins. This methodology is entirely orthogonal to existing methods that are either machine learning or enthalpy based. Not only the approach is novel but also the method performs extremely favourably compared to other methods when viewed in terms of both error and bias.
7. ABSTRACT During the last decades, it has been a huge interest from the pharmaceutical industries on essential oils and various plant extracts because of their low toxicity and high biodegrability. Copaiba oil (Cop) is a popular medicine in natural form as an anti- inﬂammatory and anti-infective agent to treat various conditions such as sore throat, ulcers, urinary and pulmonary afflictions. Emulsions are defined as a thermodynamic instable dispersed systems consisting of microscopic dispersions of liquid droplets within another liquid. The aim of this work was to prepare different Cop emulsions and evaluate their stability in order to determine the critical HLB of oil, beyond, to perform a comparative study among different methods from the construction of phase diagrams. The emulsions were prepared by the phase inversion method at different ratios varying the HLB from 4.7 to 16.7. Thestability was determined by various methods and phase diagrams were produced by titration method using different stirring procedures. Concerningthe Cop-containing emulsions, the ones that presented HLB range from 12.7 to 15.7 were the most stable. The emulsions were presented good short and long-term stability, milky aspect and low creaming index values. Different colloidal structures were produced in phase diagrams, depending on the stirring process. Based on these methods, the required HLB values of Cop were determined as 14.8, the emulsion remained stable for a period exceeding one year and these results indicate that the studied emulsion based on Cop may be a promising vehicle for topical delivery of drug and cosmetic active.
Tobacco, alcohol, and betel quid are the main causes of squamous cell cancers ofthe upper aerodigestive tract. These substances can cause multifocal carcinogenesis leading to multiple synchronous or metachronous cancers ofthe oesophagus, head and neck region, and lungs (‘ield cancerisation’). Globally there are several million people who have survived either head and neck squamous cell cancer (HNSCC) or lung cancer (LC). HNSCC and LC survivors are at increased risk of developing second primary malignancies, including second primary cancers ofthe oesophagus. The risk of second primary oesophageal squamous cell cancer (OSCC) ranges from 8-30% in HNSCC patients. LC and HNSCC survivors should be ofered endoscopic surveillance ofthe oesophagus. Lugol chromoendoscopy is the traditional and best evaluated screening method to detect early squamous cell neoplasias ofthe oesophagus. More recently, narrow band imaging combined with magnifying endoscopy has been established as an alternative screening method in Asia. Low-dose chest computed tomography (CT) is the best evidence- based screening technique to detect (second primary) LC and to reduce LC-related mortality. Low-dose chest CT screening is therefore recommended in OSCC, HNSCC, and LC survivors. In addition, OSCC survivors should undergo periodic pharyngolaryngoscopy for early detection of second primary HNSCC. Secondary prevention aims at quitting smoking, betel quid chewing, and alcohol consumption. As ield cancerisation involves the oesophagus, the bronchi, and the head and neck region, the patients at risk are best surveilled and managed by an interdisciplinary team.
The nil strength temperature (NST) for the alloy was determined by testing cylindrical Ø 6 x 90 mm specimens on the Gleeble 3800 simulator. S-type thermocouples were pressure welded to the specimens, and then the specimens were fixed in the chamber by means of copper holders. Constant distance of 52.4 mm was kept between the holders. After evacuation of air, the chamber was filled with argon (to 0.14 hPa). Then, the 0.6 – 0.7 kN minimum pre-load was applied and was maintained until the end of experiment. The specimens were heated at the 20 o C/s rate to 400 o C, and then at the 1 o C/s rate. The NST was determined as the temperature at which the specimen lost its cohesion. The NST for the ZRE1 alloy in as-delivered state is 535 o C.
Surface of C120 steel after arc plasma treatment showed tracks have multizone microstructure composed ofthe remelted zone, heat affected zone and substrate, which can have diversified microhardness. Structure (particularly precipitation of martensite, bainite retained austenite and secondary cementite) in the remelted zone is dependent on the arc plasma treatment parameters. The cooling rate obtained during the treatment by arc plasma ofthe steels is compared to the cooling rate ofthe steels during conventional heat treatment. This cooling rate can be estimated on the basis ofthe standard CCT diagram for C120 steel. Increased ofthe current intensity of arc plasma lead to of grater areas of materials remelting and it decreases ofthe cooling
The above mentioned alloys were fabricated from the following starting materials (Table 1): aluminium in grade AR1 (99,96% Al), silicon of 98,5% purity (rest Fe and other elements), copper (99, 98% Cu), nickel (99, 98% Ni) and cast AG10 alloy (about 10 wt.% Mg). Melts were conducted in a Leybold-Heraeus IS5/III induction furnace with crucible of 0,7kg capacity made from magnesite refractory material. A protective coating of 2NaF and KCl was used. When the furnace temperature of ~ 820 o C had been reached, the melt was subjected to refining treatment with Rafglin-3 in an amount of 0,3 wt.%, followed by modification with Cu-P (~9,95%P). The temperature of pouring was controlled by a NiCr-NiAl TP-202K-800-1 thermocouple immersed in the bath of molten metal.
Quality is defined as the degree of excellence or superiority that an organization’s product possesses (Khan, 2005:28). Consumers judge or perceive the quality ofthe products and it also called perception of quality, because perception of quality derived from the analysis of consumers on product quality (Sanyal & Datta, 2011:605). Customer perceived value of product quality is a consumer opinion as ability ofthe product who suitable with expectation of consumer (Terenggana et al., 2013:326). Perception of quality is formed on consumers can be affected by several things including past experience, education, purchasing and consumer community (Yaseen et al., 2011:834), and perception of quality is important in improving the quality of products in the view of consumers (Parrol et al., 2013:603). Since knowledge and consumer needs change time by time, it taken an understanding related consumer perception of quality in evaluated to be known how big influence on purchase intention (Sanyal & Datta, 2011:607). Reviewing consumer behavior in foods, in previous research is often studied through perception of quality (Carrasco et al., 2012:1414). On last studied, perceived quality is the consumer’s judgment about a product’s overall excellence or superiority (Zeithaml, 1988). Meanwhile perceived quality is the judgment a consumer of product which refers to the physical characteristics ofthe product, and is related more to engineering and food technology (Carrasco et al., 2012). Several things that concern on perception of quality, first are spoke on the advantages related to the assessment of consumer products and the second on the technology applied to products that are both better than similar products. That matter is a critical element for consumer decision making, consequently, consumers will compare the
Abstract: The research was carried with the aim to discover the existence of securing the foremost islands and state border region ofthe Republic of Indonesia reviewed from a legal perspective, which is directly related to the existence of security and dispute resolution methods as well as the governance ofthe foremost islands and border region in Kalimantan which bordering Malaysia. This study was conducted in Nunukan district and the surrounding provinces of Kalimantan, in this research method that used is normative legal analysis data with juridical and qualitative descriptive approach. The results showed that the security of foremost islands and border region of law perspective in accordance with the Law No. 34 of 2004 regarding the Indonesian National Army has not been implemented to the fullest to realize the security of foremost islands and border region as the frontline ofthe Republic of Indonesia. The existence of leading islands securing and the border region ofthe Republic of Indonesia still contain many weaknesses in terms of both governance and security.
The results of calculations ofthe areas of non-planar grain surfaces and the grain areas on the projection plane for correct and incorrect macrostructures are presented as distributions with a logarithmic width of classes in Figs. 6 and 7, respectively. 7. Parameters ofthe grain size distributions in 3D and 2D spaces are presented in Table 1. A supplementary evaluation ofthe grain size consists of a calculation ofthe shape and elongation coefficients. The results ofthe calculations are presented as distributions these values in Figures 8, 9, 10 and 11, respectively, while statistical parameters are shown in Tables 2 and 3.
stage, the content of manganese was made up with an addition of ferromanganese and the melt was held for 3 minutes. During holding ofthe melt and before tapping, the temperature of liquid iron was measured with a thermocouple. The melt was transferred to a ladle, which was next transported to the casting stand and molten metal was poured into the previously prepared moulds. Test bars with a φ 15 mm diameter and castings were made following the production regime adopted by HARDKOP Foundry at Trzebinia. As a next step, specimens were prepared for metallographic examinations. Chemical composition ofthe cast iron phase constituents was examined using a JEOL 500LV scanning electron microscope with attachment for X-ray microanalysis (EDS).
This model, preached by any teacher of electrical engineering to his students on the various levels, was given like postulate. This article proposes an analytical justification to the equivalent diagram elements of single-phase transformer current, particularly to those ofthe central branch. The article is organized in three main sections. Section II begins by the calculation of active power consumed in a parallelepiped electromagnetic domain subjected to a variable flow. The result is applied to a shell form single-phase transformer. With open load test, the power consumption linked to the leakage inductance and resistance ofthe transformer winding is neglected in front ofthe consumption ofthe central branch . But it is not the case for a loaded transformer. Themethods to determine resistances ofthe reels are indisputable. This article gives the expressions ofthe elements ofthe central branch in the model of Steinmetz starting from the powers and their site. It studies also the variation relation ofthe iron resistance and the iron reactance compared to the computed values with 220 V. Section 2 is dedicated to this calculation. Discussions and a comparison of results are described in Section 3. The final section is devoted to the article conclusion.