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[PDF] Top 20 Conservation, variability and the modeling of active protein kinases.

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Conservation, variability and the modeling of active protein kinases.

Conservation, variability and the modeling of active protein kinases.

... Protein kinases are the most ubiquitous single family of signaling molecules in the cell, accounting for approximately 2% of the proteins encoded by the human ... See full document

15

Non-degradative Ubiquitination of Protein Kinases.

Non-degradative Ubiquitination of Protein Kinases.

... simulations of ZAP-70 starting from the active and inactive-state crystal struc- tures with a ubiquitin attached at K377 or ...near the N-terminal end of the C- helix (Fig ... See full document

44

Protein kinases and plant pores.

Protein kinases and plant pores.

... purifying and characterizing the active fraction, the authors showed that the molecules responsible were small RNAs, whose sequences were very close to standard human ...tRNAs. ... See full document

18

Rational design of protein kinase inhibitors

Rational design of protein kinase inhibitors

... Introduction. Kinases are almost widest family of hu- man enzymes – about ...% of all proteins, encoded in human genome, are protein kinases [1], which in couple with their antagonists ... See full document

9

The origin and evolution of G protein-coupled receptor kinases.

The origin and evolution of G protein-coupled receptor kinases.

... G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of ...binding of arrestins, which precludes G protein ...to active GPCRs activates ... See full document

12

Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.

Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.

... computations, the 10 lowest eigenvectors captured between 85% and 90% of the total variance in the collective kinase motions, while the essential subspace covered by the ... See full document

46

Auxinic herbicides, mechanisms of action, and weed resistance: A look into recent

Auxinic herbicides, mechanisms of action, and weed resistance: A look into recent

... at the plasma membrane also activates a Rho-like small G protein called RAC/ROP ...growth and development (Berken and Wittinghofer, ...to the energy-storing molecules similar to ATP ... See full document

7

The application of optical measurements for the determination of accuracy of gear wheels casts manufactured in the RT/RP process

The application of optical measurements for the determination of accuracy of gear wheels casts manufactured in the RT/RP process

... taking the measurements, an anti-reflection coating was applied on the tested gear ...wheel. The thickness of the coating ranged from 0,8 µm do 1,2 ...µm. The measurements were ... See full document

4

The quality of castings obtained during lost-wax and Replicast CS processes in aspect of ecology

The quality of castings obtained during lost-wax and Replicast CS processes in aspect of ecology

... Haratym, Dok ł adno ć wymiarowa odlewów wykona- nych w procesie Replicast CS, Archiwum Odlewnictwa rocznik 3, nr 9, Katowice 2003.. Arendarski, Niepewno ć pomiarów, Oficyna Wydaw- nic[r] ... See full document

5

The Role of Protein Kinases in Antigen-activation of Peripheral Blood Mononuclear Cells of Schistosoma mansoni Infected Individuals

The Role of Protein Kinases in Antigen-activation of Peripheral Blood Mononuclear Cells of Schistosoma mansoni Infected Individuals

... at the con- centration of 3 x 10 5 cells/well in a final volume of 200 ...at the same time as ...mg/ml of soluble egg antigen (SEA) or soluble worm antigen prepa- ration ...inhibitor ... See full document

5

Molecular Evolution and Characterization of Hemagglutinin (H) in Peste des Petits Ruminants Virus.

Molecular Evolution and Characterization of Hemagglutinin (H) in Peste des Petits Ruminants Virus.

... invading the host, but also the important cause of the pathological changes in the host organism and presentation of clinical symptoms ...Because of this ... See full document

16

PaFlexPepDock: parallel ab-initio docking of peptides onto their receptors with full flexibility based on Rosetta.

PaFlexPepDock: parallel ab-initio docking of peptides onto their receptors with full flexibility based on Rosetta.

... refinement of coarse models of peptide-protein complex structures [5] based on the Rosetta platform ...where the peptide backbone conformation within the receptor-binding site is ... See full document

13

Modeling and Analysis of Queuing Systems in Banks A case study of Ghana Commercial Bank Ltd. Kumasi Main Branch

Modeling and Analysis of Queuing Systems in Banks A case study of Ghana Commercial Bank Ltd. Kumasi Main Branch

... from the banking hall of Ghana Commercial Bank (GCB) ...Branch. The methods used during the data collection were direct observation and personal interview and questionnaire ... See full document

4

Warming permafrost and active layer variability at Cime Bianche, Western Alps

Warming permafrost and active layer variability at Cime Bianche, Western Alps

... decadal and longer time-scale variations pen- etrate to greater depths into permafrost with less ...result the signal- to-noise ratio ...inter-annual variability) increases rapidly with depth ... See full document

42

Ana Lúcia Rebelo do Rosário

Ana Lúcia Rebelo do Rosário

... development of dendritic branch diversity though guidance and targeting, happens in a cell- type specific way, where the first level of control arises from intrinsic programs that are linked ... See full document

199

Analysis of Structure and Abrasion Resistance of the Metal Composite Based on an Intermetallic FeAl Phase with VC and TiC Precipitates

Analysis of Structure and Abrasion Resistance of the Metal Composite Based on an Intermetallic FeAl Phase with VC and TiC Precipitates

... between the properties of metals and ...strength and resistance to oxidation, combined with sufficient ductility and fracture toughness, make them an attractive material for machine ... See full document

4

Theoretical and Methodological Aspects of the ”Integration Process” Phenomenon

Theoretical and Methodological Aspects of the ”Integration Process” Phenomenon

... Numerous of political, economic and social changes in latest decades of the XX-th century, the beginning of the XXI-st century have changed essentially the world ... See full document

17

Survey of activated FLT3 signaling in leukemia.

Survey of activated FLT3 signaling in leukemia.

... al. and Zhang et al., which represent the first two large-scale Phospho-profiling of mutant FLT3 signaling, provide broad view of oncogenic FLT3 signaling to ...overexpression of mutant ... See full document

10

The Influence of Small Amounts of Aluminium on the Spheroidization of Cast Iron with Cerium Mischmetal

The Influence of Small Amounts of Aluminium on the Spheroidization of Cast Iron with Cerium Mischmetal

... beneath the metal mirror. The melt was heated again up to 1360- 1380°C, then cerium mischmetal was added, and the roasted ferrosilicon was introduced five minutes ...later. The ... See full document

6

Protein tyrosine kinases in Schistosoma mansoni

Protein tyrosine kinases in Schistosoma mansoni

... identified and characterised the molecular structure of a new PTK in ...exhibits the characteristic features of Fes/fps protein ty- rosine kinases subfamily, a coiled-coil ... See full document

8

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