Top PDF Correction: Human MicroRNA Targets.
Correction: Human MicroRNA Targets.
... We incorrectly named the products of two genes, gamma actin and betaAPP, as FMRP ligands because of a misreading of Table 1 from [1]. BetaAPP is incorrectly referred to as an FMRP ligand in Tables 2 and S9, gamma actin ...
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RFMirTarget: predicting human microRNA target genes with a random forest classifier.
... Xiao and colleagues [26], for instance, have focused in a systematic analysis of features importance carried with a random forest model, whereas here our goal is to deeply explore the predictive power of the random ...
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microPIR: an integrated database of microRNA target sites within human promoter sequences.
... promoter targets [13,14,15] were detected and included in the ...miRNA targets on most of gene upstream sequences suggests that miRNA gene regulation through promoter targeting may be a more general event ...
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MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer
... Colorectal cancer (CRC) is the fourth leading cause of cancer-induced mortality. Histone deacetylase 2 (HDAC2) is involved in prognosis and therapy of CRC. This study aimed to explore novel therapeutic targets for ...
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Genetic variants in the MicroRNA biosynthetic pathway Gemin3 and Gemin4 are associated with a risk of cancer: a meta-analysis
... mRNA targets with perfect (or nearly perfect) complementarity to induce the RNA- mediated interference pathway (Esquela-Kerscher & Slack, 2006) ...other human diseases (Kim et ...of human cancers ...
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Cigarette smoking decreases global microRNA expression in human alveolar macrophages.
... predicted targets. Using Partek Genomics Suite software, all targets predicted by either the MicroCosm or TargetScan algorithms for each miRNA were ...predicted targets of each miRNA as calculated in ...
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Functional and evolutionary significance of human microRNA seed region mutations.
... predicted targets for all pairs of miRNAs having identical ...overlapping targets is attributable to sequence variation mapping to the non-seed regions (see S1a Figure for an additional ...
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A human torque teno virus encodes a microRNA that inhibits interferon signaling.
... host targets for TTV-tth8-miR-T1, microarray analysis for human transcripts was performed on RNA harvested from HEK293TT cells transfected with TTV-tth8, TTV-MUT, TTV-SV40, or pUC control ...direct ...
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Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.
... 45 targets were estimated to have greater than 4-fold changes in protein ...into human tissue culture ...of targets contrasts dramatically with several previous studies in which miRNAs reduced ...
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Identification of human microRNA-like sequences embedded within the protein-encoding genes of the human immunodeficiency virus.
... The miRNA-like sequences we have identified in HIV-1 are unique in that they do not seem to be derived from cellular miRNA, nor do they appear to represent viral miRNAs or their targets. The hsa-miR-195-like ...
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MicroRNA expression profiles in human CD3
... Despite the role of miR-155 in Treg survival, this mol- ecule is still classified as proinflammatory, as it precisely regulates the levels of its targets to promote the immune response. Conversely, miR-146a and ...
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MicroRNA expression variability in human cervical tissues.
... inconsistency in miRNA expression between them, which may be due to differences in the high-throughput platforms and methods used in different laboratories or due to differences among the cancer population. Also, a full ...
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Rapid generation of microRNA sponges for microRNA inhibition.
... effectively inhibit miRNAs while sponges with perfect MBS do not. A limited effect on cell growth was observed using two bulged MBS and similar strong effects were observed using sponge constructs containing six and ...
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Comparative genomics allowed the identification of drug targets against human fungal pathogens
... There is no crystallographic structure presently avail- able for TRR1 and KRE2 of P. brasiliensis and also for the other pathogenic fungi. Therefore, the 3D struc- tures of TRR1 and KRE2 of P. brasiliensis were con- ...
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Final report
... 84. Delegates made a number of suggestions both for enhancing PAHO’s approach and for improving the document. The Delegate of Costa Rica, alluding to the strategic priorities for PAHO listed in paragraph 35 of the ...
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ROLA POWIATU W ROZWOJU CYWILIZACYJNYM. PRZYPADEK MAŁOPOLSKI
... QLHSU]H]]DU]ąG]DQLHGURJDPLNWyUHOLF]ąRNRáRNP:\UDĪDMąRQLĪDOLĪSRZLDWQLH VWDQRZLMHGQRVWNLNRRUG\QXMąFHMG]LDáDQLHJPLQZ\ZLDG\í=RSLQLLEDGDQ\FKPRĪQD ZQLRVNRZDü LĪ ]ZLą]NL PLĊG]\ JPLQą SRZLDWHP L [r] ...
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Identificação de ligantes da chiquimato quinase de Mycobacterium tuberculosis por docking molecular
... Tuberculosis (TB) is the most important cause of human death from a curable infectious disease. It is estimated that, worldwide, one hundred million people are infected annually and about ten million develop the ...
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Einstein (São Paulo) vol.12 número2
... Resveratrol is also capable of increasing the levels of miR-663, a tumor-suppressor miRNA that targets TGF-β1 transcripts. The results of this study indicate that since, it is possible to manipulate the levels of ...
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FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.
... of human and mouse homologues regions using VISTA computational comparative tool, reveals that the FADS1 and FADS2 overlapping 59 UTR region is less conserved (identity #70%) (Figure S3, VISTA computational ...
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Long non-coding RNAs as potential therapeutic targets in human breast cancer
... LncRNAs have key roles in gene regulation and, consequently, affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. Cancer is primarily caused by genetic ...
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