[PDF] Top 20 Corticosterone does not change open elevated plus maze-induced antinociception in mice

... and corticosterone (Taylor et al., 1998) which, in turn, may increase anxiety (Steimer and Driscoll, 2003), we have hypothesized that the high plasma levels of corticosterone induced by ... See full document

... Findings: In the mouse pilocarpine-induced epilepsy model, we administered levetiracetam (LEV) and valproate (VPA) in ...AED-resistant mice were naturally selected after 7-day treatment of LEV ... See full document

... (but not at 0.01 and 1.0 mg/kg) in both the open field and elevated ...plus-maze. In agreement with these data, we observed no change in gait or in ... See full document

... the elevated plus- maze test is only valid to evaluate anxiolytic effect if motor function is not altered (Dawson et ...tested in this ...both in percentage of open arm ... See full document

... the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in ...nociception ... See full document

... Dyn/KOP in anxiety control is not well ...KOP-deficient mice are relatively rare and do not provide a consistent picture of the functions of Dyn/KOP in ...anxiety. In Pdyn KO ... See full document

... deficient mice in multiple behavioral tests performed both individually (summarized in Table 1) and also in the IntelliCage ...performed: elevated plus-maze, open ... See full document

... of mice in the forced swimming test (FST) and in the elevated plus-maze ...behavior in the second test (PM or FST, respectively) was compared to handled animals ...the ... See full document

... hyperactivity does not appear to be the explanation of the current data, decreased anxiety in IL-1RI 2/2 mice appears the more likely ...decrease in anxiety is consistent with one ... See full document

... demyelination induced by toxic agents; (3) inducible models of EAE (Batoulis et ...transgenic mice models that spontaneously develop EAE (Croxford et ...2011). In this model, the animals are ... See full document

... spent in the open and closed arms; number of open and closed arm entries (arm entry= all four paws within the arm); percentage of open-arm entries [(open total/300) × 100]; and ... See full document

... variable in the rats treated with DZP is shown in Figure ...DZP induced a statistically significant in- crease in locomotor ...benzodiazepine induced an opposite ef- fect, ... See full document

... is not definitive since a careful analysis using dif- ferent antagonist doses is required, this in- terpretation seems to support the physiologi- cal role of histamine receptors in the ventral ... See full document

... activity in the open field, the lack of anxiolytic and antidepressant activities in the plus maze, tail suspension and forced swimming ...tests. In general, drugs possessing ... See full document

... The elevated plus-maze test was con- ducted as described in ...two open and two enclosed arms of equal length and width (50 x 10 ...The open arms had a 1-cm high Plexiglas edge ... See full document

... the literature indicating the proposed absolute configuration. The antinociceptive activity of bergenin was evaluated by the writhing test. Intraperitoneal administration of bergenin (12.5-100 mg/kg) 30 min before the ... See full document

... either in FFAs or in insulin, leptin, or glucose serve as precise aferent signals to the hy- pothalamus indicating decreasing energy ...changes in these would be directly per- ceived (L e v i n and R ... See full document

... group in the thiazole ring and the substitution of the Br in the phenyl-thiazole group with a methyl radical completely abolished its antinociceptive ac- ...group in the thiazole ring and the Br ... See full document

... Figure 3 shows the temporal behavior of laser intensity as consequence of soot particle formation during C 2 H 2 /O 2 and C 2 H 2 /O 2 /Ar combustion processes for mixtures 3-6. The temporal behavior of soot formation is ... See full document

... do not mimic the condition of anxiogenesis found in sleep-deprived ...individuals. In fact, while a sleep-deprived individual presents a prominent state of anxiety, most of the animal studies show a ... See full document