[PDF] Top 20 Deletion of ASK1 Protects against Hyperoxia-Induced Acute Lung Injury.

... member of the mitogen-activated protein kinase kinase kinase (MAPKs) group and is necessary for ROS induced cell death and inflam- mation ...[8]. ASK1 is prompted by many types of stimuli ... See full document

... development of acute lung injury ...inhibitor of histone deacetylase, has been demonstrated to inhibit HMGB1 ...effect of sodium butyrate on burn-induced lung ... See full document

... expression of various antioxidant enzymes, rendering them sus- ceptible to hyperoxia-induced lung injury [35] and increasing their susceptibility to the pulmo- nary inflammation and ... See full document

... binding of the antibodies was blocked by incubating them with 100 mL of 5% normal goat serum for 20 ...the lung sections were incubated overnight at 4°C in the presence of mouse anti-rat HMGB1 ... See full document

... Inhibition of LPS-induced lung inflammation by OroA ...sections of the rat lung tissues were stained with hematoxylin and ...arrowhead) of activated alveolar ...concentration ... See full document

... levels of Bcl-2, Bad, superoxidase dismutase 1(SOD), catalase (CAT) and Peroxiredoxin 1 (Prdx1) were measured in MTX-treated cells with or without the pretreatment of ...ml of the cDNA and 16 KAPA ... See full document

... aggravate lung damage ...rate of the removal of excess water, which then infiltrates alveolar and interstitial spaces ...marker of neutrophil infiltration in lung tissues, can exacerbate ... See full document

... clamping of the renal artery in the left kidney for 60 ...tion of glutathione (GSH) and Thiobarbituric Acid Reactive Substances (TBARS) ...evaluation of the production of cytoplasmic reactive ... See full document

... utilization of Renin-Angiotensin System (RAS) inhibitors is an effective approach for the management of patients with essential hypertension or a high cardiovascular risk as well for congestive heart ... See full document

... ing lung ultrastructure in malaria [3-5]. These papers, looking at lung injury caused by ...endothelium of alveolar capillaries, interstitial oedema and thickening of the septa as well ... See full document

... ministration of thalidomide to mice modi- fied the cytokine response to the intravenous injection of ...inhibition of serum IL-6 was observed at ...effect of thalidomide on IL-6 may be ... See full document

... analysis of linear or quadratic tendency was ...mean of the variable would increase or decrease over time, and there would therefore be no ...mean of the variable would increase or decrease up to a ... See full document

... stability of hemodynamic, respiratory and gas exchange variables in an animal model of oleic acid-induced acute lung ...administration of oleic ...acid-induced ... See full document

... 75% of cases of ...amount of fibrosis observed ...rim of unaf- fected lung at the pleuroparenchymal interface) and tracking of opacities along lower-zone bron- chovascular ... See full document

... development of cardiovascular diseases [1, 9, 37, ...component of the UPR signaling [39]. From our data, tunica- mycin-induced ER stress is evidenced by elevated expression of GRP78 and ... See full document

... feature of radiation pneumonitis is excessive leakage of fluid from the vessels into the alveolar space, which could impede alveolar gas ...removal of pulmonary edema fluid from the alveolar space ... See full document

... component of several metalloproteins involved in crucial metabolic processes such as oxygen sensing and transport, energy metabolism and DNA ...formation of damaging radical species via Fenton-type ... See full document

... right lung lobes (1×1×1mm) were also randomly sampled, followed by fixation in ...ultrastructure of the alveolar type II epithelial cells (AEC-II) was then observed using a Philips TECNAI10 electron ... See full document

... mechanisms of HO-1 ...promoter of HO-1 ...activation of HO-1 ...inhibitors of the extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, atten- uated induction of the HO-1 ... See full document

... Inhalation of significant quantities of pure silica dust, and/or mixed dusts with aluminum and magnesium silicates, is responsible for the clinical pneumoconiosis known as silicatosis, or ...manifestation ... See full document