[PDF] Top 20 Development of a new pharmacogenomics system for lung cancer based in next generation sequencing
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Development of a new pharmacogenomics system for lung cancer based in next generation sequencing
... tumoral para diagnóstico recorre à obtenção de um pedaço do tumor, normalmente retirado por cirurgia. Este é designado por biópsia sólida e apresenta várias desvantagens na aplicação da medicina de precisão. A deteção de ... See full document
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Microbial contamination in next generation sequencing: implications for sequence-based analysis of clinical samples.
... pervasiveness of this observation led us to investigate this issue using data from a variety of other publically available data ...line of investigation, we downloaded RNA-seq datasets from 93 ... See full document
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Next-generation sequencing-based transcriptome analysis of Helicoverpa armigera Larvae immune-primed with Photorhabdus luminescens TT01.
... incapable of adaptive immunity, immunal reactions which are functionally similar to the adaptive immunity of vertebrates have been described in many studies of invertebrates including ... See full document
13
Next-generation sequence analysis of cancer xenograft models.
... Next-generation sequencing (NGS) studies in cancer are limited by the amount, quality and purity of tissue ...samples. In this situation, primary xenografts have proven ... See full document
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Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility.
... association of MCPH1 c.904_916del heterozygosity with inherited breast cancer predisposition, and adds yet another link to human disease for the multifunctional MCPH1 ...protein. In the currently ... See full document
14
Development of a low bias method for characterizing viral populations using next generation sequencing technology.
... using next generation sequencing can thus provide a deeper understanding of the variability present in an HIV population compared to traditional sequencing and can be further ... See full document
9
Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.
... Integration of the viral DNA into host chromosomes was found in most of the hepatitis B virus (HBV)–related hepatocellular carcinomas ...parallel sequencing (MAPS) method using ... See full document
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An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.
... variety of mechanisms. A somatic substitution in LUDLU-1 is likely to lead to p53 ...ortholog in mice, does not directly cause cancer but increases the likelihood of spontaneous tumour ... See full document
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Molecular typing of lung adenocarcinoma on cytological samples using a multigene next generation sequencing panel.
... Identification of driver mutations in lung adenocarcinoma has led to development of targeted agents that are already approved for clinical use or are in clinical ...number ... See full document
6
Unveiling distribution patterns of freshwater phytoplankton by a next generation sequencing based approach.
... comparisons of results from very different aquatic ...analyses in different laboratories around the globe. Since this sequence-based taxonomic identification can be done in an identical way ... See full document
10
Application of Next-generation Sequencing in Clinical Molecular Diagnostics
... aim of the Human Genome Project (HGP) was the sequencing of 3 billion nucleotides of DNA and identifying the ...result in the development of diagnostic tools, novel ... See full document
15
Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing.
... mutated in CLL (TP53, SF3B1, ATM, NOTCH1, XPO1, MYD88, DDX3X) are comparable to other studies [6–8, 10, 13, ...Most of the mutations detected are located at typical hotspot locations, such as the ... See full document
17
A trial of karyotypic microdissection as an enrichment pathway for next-generation sequencing
... said of genome complexity. Due to sequencing platform biases and limitations, complex genomic regions may either go unsequenced, or impose several constraints to its post-sequence ...genome ... See full document
104
Detection and removal of biases in the analysis of next-generation sequencing reads.
... function of transcript length. We divided all exons into five bins based on the length of the transcripts comprising them and examined mappability across the region surrounding the exon/intron ... See full document
12
Quantifying Next Generation Sequencing Sample Pre-Processing Bias in HIV-1 Complete Genome Sequencing
... number of small genomic ...the development of drugs that target different steps in the viral life cycle ...[18]. In recognition of this need, studies that combine both the full ... See full document
14
Correction: A Next-Generation Sequencing Method for Genotyping-by-Sequencing of Highly Heterozygous Autotetraploid Potato.
... Uitdewilligen JGAML, Wolters A-MA, D’hoop BB, Borm TJA, Visser RGF, van Eck HJ (2013) A Next- Generation Sequencing Method for Genotyping-by-Sequencing of Highly Heterozygous Autotetrapl[r] ... See full document
1
The mosaic architecture of Aeromonas salmonicida subsp. salmonicida pAsa4 plasmid and its consequences on antibiotic resistance
... regions in the three plasmids harboring most of the conjugative transfer genes also displayed the most differences ...inversion of the traLEKBVA locus and the surrounding region seemed to have ... See full document
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A MANUFACTURING CELL CONTROLLER ARCHITECTURE
... implementation of the RS232 or RS485 protocol is very cheap, but it requires the development of an API (Application Program Interface) for each industrial resource, customized to the resource ... See full document
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Next Generation Semiconductor Based Sequencing of the Donkey (Equus asinus) Genome Provided Comparative Sequence Data against the Horse Genome and a Few Millions of Single Nucleotide Polymorphisms.
... each of the sequenced and aligned dataset described above the combination of the mpileup and bcftools functions of Samtools [50] was used for calling variants (SNPs) without any pre- set ...were ... See full document
18
Probing the SELEX process with next-generation sequencing.
... number of about 13 million reads by Illumina sequencing, of which 56% could be sorted according to their barcodes (see Table ...inserts of 40 bases with a tolerance of two bases ... See full document
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