[PDF] Top 20 Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis

... identify tumor-derived factors that pro- mote bone metastasis, we developed an in vivo selection strate- gy to isolate bone-metastatic breast cancer variants ...of ... See full document

... influence tumor development at primary as well as in metastatic sites, but there have been no direct comparisons of the transcriptional profiles of stromal cells from different tumor ...sites. ... See full document

... RANK/RANKL/OPG in the primary tumor (e.g. prostate, HCC, not in breast cancer) and propensity to develop bone metastasis ...(mostly breast, colorectal, renal, lung, ... See full document

... promote tumor progression and metastasis in at least two compartments of the mammary tumor microenvironment, including tumor macrophages and breast stromal fibroblasts ... See full document

... increase in MMP2 and MMP9 expression levels in response to AngII stimulation, although results did not reach significance due to heterogeneity of probesets ...player in cell-cell adhesion and trans- ... See full document

... factors in patients with bone metastases. In a study of 350 patients with skeletal metastases, Katagiri et ...primary tumor type, and absence of visceral metastasis were significant ... See full document

... define breast cancer metastasis ...performed in this report provide a comprehensive view of changes in gene expression elicited by over-expression of WNT5A in metastatic ... See full document

... promotes tumor-associated macrophage recruitment and infiltration in breast ...death in BC patients and have a special tropism to develop in the ...the bone are not fully ... See full document

... 5-year breast cancer survival rate is generally greater than 90% but it is roughly 55% in women with numerous lymph node metastases ...of breast cancer associ- ated with nodal ... See full document

... orbital metastasis from hepatocellular carcinoma is usually straightforward and com- monly guides the investigation toward the primary ...of tumor cells with CAM ...elevated in up to 90% of patients, ... See full document

... enrolled in this ...node metastasis, tumor size and pathological features ...Joint Cancer Committee (AJCC) tumor-node-metastasis (TNM) stage were ...The tumor size was ... See full document

... shown in other ...implicated in IBC models [5, 6] and macro- phage TNF-α, IL-6, and IL-1β can induce TGF-β and EMT in MCF-7 cells ...expressed in over 80% of patients with relapsed ... See full document

... lung, breast, renal, colorectal cancers and ...frequently in individuals with ad- vanced-stage ...known. Interactions between circulated tumoral cells (CTC) and blood-brain-barrier (BBB) cells are ... See full document

... and metastasis, we used three algorithms (Targetscan, Pictar and Miranda) to help identify miR-26a targets in human gastric ...implicated in tumorigenesis or metastasis ...sites in the ... See full document

... Each cancer should be considered individually when deciding on the most appropriate treatment ...the tumor, chemotherapy and radio- ...the tumor is possible, but in most cases, it is combined ... See full document

... do tumor (> 5,0 cm), índice mitótico (> 5 / 10 campos de grande aumento), infiltração locorregional e presença de metástases à época do diagnóstico podem pre- dizer um comportamento mais agressivo da doença ... See full document

... Figure 1. A: Ultrasound showing a solid, hypoechoic, irregular spiculated nodule, ad- jacent to the papilla of the right breast. B: Right breast biopsy showing massive infil- tration by grade III invasive ... See full document

... O estudo fitoquímico dos extratos de Me 2 CO da planta inteira e seca de Euphorbia portlandica levou ao isolamento de um novo álcool triterpênico pentacíclico, com o esqueleto do lupano, designado por lupeportlandol. A ... See full document

... as in agreement, underestimated, or overestimat- ed, in relation to the size determined by ...residual tumor deter- mined by pathology correlated with that determined from the CESM and FFDM ... See full document

... The breast tumor was classified as clinical stage IV, with metastasis to the lungs (lymphangitis carcinomatosa identified on CT) and bones, and surgery for the breast lesion was therefore not ... See full document