[PDF] Top 20 DNA methylation analysis of the tumor suppressor gene CDKN2B
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DNA methylation analysis of the tumor suppressor gene CDKN2B
... that the degree of loss of protein produc- tion is not uniform throughout the tumor-cell population, unlike the one that is produced by the genetic changes (Jones and ... See full document
7
Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.
... , the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor ...1 of ... See full document
8
MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation.
... Processing of the precursor transcripts by dicer generates three mature miRNAs: miR-219-5p from the 59 ends of both precursors, and miR-219-1-3p and miR-219-2-3p from the 3 9 end ... See full document
11
Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.
... processes of specific genomic regions. (A) The concept of estimation of the fraction of cancer cells in a tumor DNA sample using DNA ...Selection of ... See full document
10
Corruption of the intra-gene DNA methylation architecture is a hallmark of cancer.
... meta-analysis of the fourteen data sets was carried ...on the mean z-score measure) across all data sets by a permutation method (see ‘Methods and Models’ for details); this identified over ... See full document
11
Divergence of gene body DNA methylation and evolution of plant duplicate genes.
... promoter methylation and small RNA abundance, and physical distance simultaneously, we pooled the CHM and NCM duplicate genes together to compute the partial correlation between expression divergence ... See full document
17
Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.
... degree of cooperativity. Importantly, combined expression of EE and RR (EE/RR) results in mixed tetramers in which one negatively and one positively charged H1 helix interact, resulting in a DNA ... See full document
15
Dan Wu 1,3 , Jinli Zhang 1, , Peiwen Fan1
... reconstruction of a host cell in the process of malignant transformation, resulting in HPV phenotype in cervical cancer ...in DNA methylation transferase activity. Whether ... See full document
9
Genome-wide DNA methylation patterns and transcription analysis in sheep muscle.
... DNA methylation plays a central role in regulating many aspects of growth and development in mammals through regulating gene ...expression. The development of next generation ... See full document
7
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
... for the fatty acid uptake. N-terminus of ACSL3 is required for the translocation from the endoplasmic retic- ulum to lipid droplet (LD) ...inhibits the lipid droplet formation [35,36]. ... See full document
23
Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.
... models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both ...processes. DNA methylation is a key epigenetic mark ... See full document
22
CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.
... a tumor suppressor that impairs the development and disables the maintenance of MYC- driven ...levels of TTP, suggesting that it may function as a tumor suppressor ... See full document
24
Genetic alterations in head and neck squamous cell carcinomas
... loss of nor- mal function of the TP53 tumor suppressor gene is believed to contribute to the develop- ment of the majority of human cancers ... See full document
8
Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor.
... views of the growth regulatory properties of TSG101-like proteins provided by mammalian and insect models suggest either that TSG101 is required for the endocytic degradation of a ... See full document
10
The prima donna of epigenetics: the regulation of gene expression by DNA methylation
... regarding the effect of DNA hypomethylation is gene ...matter of fact, H-RAS, C-MYC, CT genes (genes normally expressed in the tes- tis and aberrantly activated in tumors), MAGE ... See full document
11
Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence.
... in the analysis other biological and clinical factors other than drug use that might modify DNA methylation, we performed a second analysis by exporting normalized b values from Genome ... See full document
12
Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells
... — The CpG dinucleotides investigated in the hTERT gene promoter ranging from -697 to - ...near the transcriptional start site. There was one CpG island located in the promoter of ... See full document
8
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
... to the silencing of genes with tumor suppressor ...activities. The isoform A of the Ras-association domain family member 1 (RASSF1A) gene is one of ... See full document
12
Open Análise de metilação de DNA nos genes da citoqueratina 14 e 19 em amostras de pele exposta e não exposta ao sol
... in DNA and increase the risk of developing skin ...about the ability of UV radiation to cause epigenetic changes in the ...skin. DNA methylation, characterised by ... See full document
43
Braz. Dent. J. vol.22 número5
... odontogenic tumor characterized by spindle or stellate-shaped cells embedded in an abundant myxoid or mucoid extracellular ...matrix. DNA methylation is characterized by the addition of ... See full document
6
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