Top PDF Dysfunction of neutrophils in patients with peptic ulcers, complicated with bleeding

Dysfunction of neutrophils in patients with peptic ulcers, complicated with bleeding

Dysfunction of neutrophils in patients with peptic ulcers, complicated with bleeding

Summary. To analyze a role of leukocytes dysfunction in the pathogenesis of ulcer bleeding the oxygen dependent metabol- ism, phagocytic activity and cytochemical indices of neutrophils were estimated in 100 patients with gatric and duodenal ulcers bleeding with effective hemostasis (group 1, n = 77) and rebleeding (group 2, n = 23). It was shown that peptic ulcer bleeding in patients of group 1 was associated with moderate increase of spontaneous production of active oxygen radicals, restriction of induced NADPH oxidase activity, decrease of acid phosphatase and myeloperoxidase activity but enhancement of phagocytic index. Sharp increase of spontaneous NBT-reaction with lost of oxidize functional reserve in neutrophils with significant inhibition of ability to phagocytosis and decreased of lysosomal enzymes activity were risk factors for rebleeding in patients of group 2.
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Endoscopic management for peptic ulcer bleeding.

Endoscopic management for peptic ulcer bleeding.

30. Lau JY, Sung JJ, Lam YH, Chan AC, Ng EK, Lee DW, Chan FK, Suen RC, Chung SC. Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. N Engl J Med. 1999; 340(10):751-6. 31. Rutgeerts P, Rauws E, Wara P, Swain P, Hoos A, Solleder E, Halttunen J, Dobrilla G, Richter G, Prassler R . Randomised trial of single and repeated fibrin glue compared with injection of

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A STUDY ON ENDOSCOPIC EVALUATION OF UPPER GASTROINTESTINAL BLEEDING

A STUDY ON ENDOSCOPIC EVALUATION OF UPPER GASTROINTESTINAL BLEEDING

The mean age of patients was 47.03 years with male: female ratio of 2.33:1. 58% of patients were first time bleeders. Majority of patients presented with melaena. Visualisation of active bleeding achieved to 85.7% when endoscopy was done within first 24 hrs. The commonest cause of UGIB was duodenal ulcer (DU) which accounted for 41% cases. Gastric ulcer was responsible in 13% of cases. Portal hypertension was responsible for bleed in only 13%. Neoplasms accounted for 25% of cases. Other less common causes were erosive gastritis (3%), gastric polyp (3%), Mallory-Weiss tear (1%), and Dieulafoy’s lesion (1%). Among bleeding peptic ulcers, 27.8% of cases were classified as Forrest IIa and 20.4% in Forrest IIb & IIc each. Acid peptic disease was past history elicited in majority (33%) followed by NSAID (26%) and alcohol (26%).
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Clinics  vol.60 número6

Clinics vol.60 número6

METHODS: Patients who had failed one or more eradication regimens against H. pylori infection underwent upper gastrointestinal endoscopy. Biopsy specimens were taken from the gastric antrum and corpus for histology and for a urease test and. Patients received omeprazole 20 mg, bismuth citrate 240 mg, tetracycline 500 mg, and furazolidone 200 mg, all twice daily for 7 days. Therapeutic success was evaluated by endoscopy and biopsies 8 weeks after the end of treatment.

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Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis

Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis

Objectives. To test the relation between white matter lesions (WML) location and physical performance, in aged patients. Methods. Subjects: 29 patients (17 males), aged >65 (mean age 72.6 ± 5.2), with leukoaraiosis. WML was quantified with a visual scale; Apparent Diffusion Coefficient (ADC) was measured bilaterally in frontal periventricular lesioned white matter and frontal and parieto-occipital normal appearing white matter (NAWM). Motor performance was studied using the Short Physical Performance Battery (SPPB), single leg stand time, finger tapping and grooved pegboard tests (GPT). Results. There were significant correlations between the frontal region visual scale scores and SPPB chair stands (r = − 0.379; P = . 039) and Grooved Pegboard (r = 0.393; P = . 032); frontal NAWM ADC values and SPPB standing balance (r = − 0.450; P = . 014) and SPPB 4 meter walk (r = − 0.379; P = . 043). Conclusion. Frontal WML are negatively related to motor performance in patients with leukoaraiosis. DWI results suggest that this may be true even for NAWM.
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WP114 No Impact of Rural Development Policies? No Synergies with Conditional Cash Transfers? An Investigation of the IFAD-Supported Gavião Project in Brazil

WP114 No Impact of Rural Development Policies? No Synergies with Conditional Cash Transfers? An Investigation of the IFAD-Supported Gavião Project in Brazil

Despite having provided US$18.5 billion in grants and low-interest loans since 1977, there is little rigorous evidence on the impact of IFAD projects around the world. There is a similar lack of evidence on synergies between rural development projects and conditional cash transfer policies. In an effort to address this gap in the literature, we explored the impacts of an IFAD- supported rural development project —Pro-Gavião—in 13 municipalities of Brazil, and possible synergies with the Bolsa Família conditional cash transfer program. The paper used a matching technique to create a control group of untreated census tracts, and a difference-in-differences estimation to identify policy impacts. The findings were unexpected. When examining the main outcomes of land productivity, agricultural income, and child labor—all available in the Agricultural Censuses—we found no statistically significant evidence to support a positive impact of Pro-Gavião or of synergies between the two programs. The presence of Bolsa Família seems to have improved access to credit, and there was some evidence showing a likely association between the interaction of the policies and improved access to electricity. These results are robust to different matching techniques, ways of defining the treated locations, and heterogeneity by initial level of poverty.
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Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

Recurrent aphthous ulcer (RAU) is a lesion of the oral mucosa that is characterized by multiple recurrent, small, round or ovoid ulcers with circumscribed margins, erythematous haloes and yellow or gray floors (1-3). Although RAU lesions are very commonly observed in the oral mucosa, the exact etiological factor(s) are not yet understood. Contributing factors include allergies, genetic predisposition, hormonal influences, hematologic abnor- malities, immunologic factors, infectious agents, nutritional deficiencies, smoking cessation, stress, and trauma. These factors have a direct or indirect potential for disturbing the equilibrium between oxidant and antioxidant systems in humans. The formation of free radicals could be acceler- ated and toxic reactions could occur once this equilibrium is disturbed (4,5).
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Reengineering of Permanent Mould Casting with Lean Manufacturing Methods

Reengineering of Permanent Mould Casting with Lean Manufacturing Methods

At the work were introduced main areas of production system project of casts produced in permanent moulds, that constitutes reengineering of conventional production system according to Lean Manufacturing (LM) methods. New resolution of cooling of dies with water mist was shown to casting of car wheels made from aluminium alloys in low pressure casting process. It was implemented as a part of goal-oriented project in R.H. Alurad Sp.z o.o. in Gorzyce. Its using intensifies solidification and self-cooling of casts shortening the time of casting cycle by the 30%. It was described reorganizing casting stations into multi-machines cells production and the process of their fast tool’s exchange with applying the SMED method. A project of the system was described controlling the production of the foundry with the computer aided light Kanban system. A visualization of the process was shown the production of casts with use the value stream mapping method. They proved that applying casting new method in the technology and LM methods allowed to eliminate down- times, to reduce the level of stocks, to increase the productivity and the flow of the castings production.
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Selfesteem of people with venous ulcers

Selfesteem of people with venous ulcers

The sociodemographic variables surveyed were: sex; age group; marital status; schooling; occu- pation and per capita income. Regarding the care cha- racteristics, the following factors were considered: the availability of products for the dressings, time of treat- ment of the ulcer in months (≥6 months and ≤6 mon- ths), training or lack of training of the professional/ caregiver who perform the dressing; guidance provi- ded by the health professional such as the use of com- pressive therapy; lifting the lower limbs to an elevated position, and regular exercise, use of compressive the- rapy and number of consultations with the angiolo- gist in the last year (none or ≥1). The clinical variables were: recurrences (≥1 or none); time of presence of the venous ulcer (>1 year or up to 1 year); size of the venous ulcer (mean to large >50cm 2 or small ≤50cm 2
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Re: Erectile dysfunction in patients with chronic renal failure

Re: Erectile dysfunction in patients with chronic renal failure

The association of chronic renal failure (CRF) to erectile dysfunction (ED) is a well known fact, but the prevalence of ED obtained in this population is variable. The lack of an standardised instrument for ED assessment before generalisation of the international index of erectile function (IIEF) and the

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Arq. Gastroenterol.  vol.49 número2

Arq. Gastroenterol. vol.49 número2

of technical complications was observed. This series shows an initial experience, started many years ago charactering different expertises and devices, during the period here analyzed. Nowadays technical com- plications like cervical hematoma, pneumothorax and hemothorax could be avoided with the use of ultra- sound guidance to perform the transjugular approach. This may be result of the learning curve associated to the group performing TIPS.

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Re: Erectile dysfunction in patients with chronic renal failure

Re: Erectile dysfunction in patients with chronic renal failure

The prevalence of their study was 31.4% and 68.6% between patients younger and older than 50 years, respectively. Age, diabetes mellitus & hemo- dialysis characteristic were associated with higher incidence of ED (2), while they found that neither hypertension (even it is common) nor the duration of dialysis are associated with ED. They brilliantly sug- gest to all physician and all health professional to pay more attention to their patients’ sexual problems.

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Stage effect of chronic kidney disease in erectile function

Stage effect of chronic kidney disease in erectile function

Some studies registered influence of CKD stages and GFR on erectile function (10, 12, 15, 17, 18, 23). Apparent worsening or worsening of sexual function, with progression of uremia, was reported by 137 (48%) of 287 men on hemodialy- sis, before starting this treatment (12). Forty-five percent of 32 male married patients on dialysis reported sexual potency decrease, after onset of renal disease (23). Direct correlation between IIEF and GFR, in outpatients with CKD, stages III and IV, was showed in preliminary results (18). Analy- sis of 183 men undergoing coronary angiography, to detect acute myocardial infarction, found ED correlating with lower GFR, in patients with single arterial coronary disease (15). Patients with type 2 DM had ED associated with albuminuria and lower GFR levels (17). Adult male patients with ED and chest pain, presumably of coronary origin, had a worse GFR (24). As the severity of the ED increased, a more severe decrease in the creatini- ne clearance occurred in male subjects with chest pain (25). Observational research involving 270
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Non-invasive Oxygen-Ozone therapy in treating digital ulcers of patients with systemic sclerosis

Non-invasive Oxygen-Ozone therapy in treating digital ulcers of patients with systemic sclerosis

34. Degli Agosti I, Ginelli E, Mazzacane B, Peroni G, Bianco S,Guer- riero F, Ricevuti G, Perna S, Rondanelli M. Effectiveness of a Short-Term Treatment of Oxygen-Ozone Therapy into Healing in a Posttraumatic Wound. Case Rep Med 2016; 2016:9528572. 35. H. Galkowska, U. Wojewodzka, and W. L. Olszewski, “Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers,” Wound Repair and Regeneration 2006; vol. 14, no. 5, pp. 558-565.

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Rev. Hosp. Clin.  vol.56 número1

Rev. Hosp. Clin. vol.56 número1

plus amoxicillin 1.0 g and clarithromycin 0.5 g bid. They show that the use of amoxicillin instead of tinidazole increases the eradication rate, which is similar to the results ob- served in developed countries. Side ef- fects were reported by 18% of our pa- tients, usually mild ones, therefore not interfering with adherence to treatment. Only one patient with persistent nau- sea and vomiting resulted in with- drawal from treatment. As observed by other investigators, we expected to find a higher eradication rate in males, since women would theoretically have been exposed to treatment with nitroimidazoles 30,31 more often, and
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Pressure ulcers in patients with traumatic spinal cord injury: subsidies in microbiological identification

Pressure ulcers in patients with traumatic spinal cord injury: subsidies in microbiological identification

Objective: To determine the prevalence of bacterial species in pressure ulcers (PU) in patients with spinal cord injury treated by a Physically Handicapped Association. Method: A descriptive, cross-sectional, quantitative study, conducted in a northeastern city from 2009 to 2010. The sample was consecutive, not probabilistic and comprised 20 individuals with spinal cord injury and PU being treated in the Association and without antibiotic therapy. Samples were collected from exudates of PU, using sterile swabs, plated on Blood Agar plates and incubated at 35°C for 24 hours. For identification of microorganisms were employed biochemical tests. Descriptive statistics were used for data analysis. Results: The six microorganisms were: S. aureus, S. epidermidis, S. saprophyticus, Proteus spp., Escherichia coli and Enterobacter spp. Conclusion: Additional prospective microbiological investigations are needed to assess the prevalence of pathogens in patients with PU injured thus instituting, nutritional, therapeutic and educational programs that reduce bacterial colonization and infection. Descriptors: Pressure ulcer, Microbiology, Spinal cord injuries.
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Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction.

Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction.

To examine whether the serum from the CAR patient recognized retinal bipolar cells, we carried out an immunohistochemical analysis on monkey and mouse retinas. We first performed immunohistochemistry on the retina of a 3-year-old rhesus monkey (Macaca mulata) and on the retina of a one-month-old C57/B6 mouse using the serum of the CAR patient, however, we did not obtain a significant staining signal above background (data not shown). We then concentrated the serum by IgG purification followed by filter spin column centrifugation and performed immunohistochemistry on the monkey retina using the concentrat- ed serum (Fig. 3D–G). We observed a significant immunolabeling on the INL in the monkey retina (Fig. 3D, F) whereas the normal serum did not give a significant labeling (Fig. 3E, G). The antibodies immuolabeled both the bipolar side and amacrine side of the INL. Since most of the cells residing on the outer side of the INL are ON bipolar cells, at least some of the stained cells are ON bipolar cells. It should be noted some of the staining signals show a spotted pattern in the outer plexiform layer (Fig. 3F) as is observed in TRPM1 or mGluR6 immunostaining on the mouse retina [13], suggesting that the CAR patient serum recognizes the bipolar dendritic tips where some of the TRPM1 protein localizes.
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Psychol. Neurosci.  vol.5 número1

Psychol. Neurosci. vol.5 número1

The present article describes the neuropsychological performance of a preteen with conduct disorder. The patient had preserved global cognitive functioning but obvious dificulties in several cognitive domains. With regard to her intelligence proile, a remarkably low score on concepts was found. This subtest is part of perceptual reasoning and could indicate potential problems learning new material when dealing with abstract concepts. With regard to attention, dificulties were found in the inhibition of environmental stimuli or her own thinking and a failure to maintain focus during lengthy tasks. With regard to mnemonic function, an adequate capacity to learn the verbal component (75% of learning) and visual component (77% of learning) was found. However, she presented poor long-term recall because of weaknesses in organization during storage, attentional failures, and dificulty creating metamemory strategies. With regard to gnosis and praxis, laws were notable in the planning of the execution of movements required to complete a task eficiently. With regard to language, the subject presented poor understanding of complex verbal instructions, repetition, and fragmentation to
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Luisa Caricio Martins+ , Tereza Cristina de Oliveira Corvelo, Samia Demachki, Marialva TF Araujo, Mônica Baraúna Assumpção, Simone Cristina Araujo Jucá Vilar, Felipe Bonfim Freitas, Hivana Patricia Melo Barbosa, Amanda Alves Fecury, Renata Kelly Costa do

Luisa Caricio Martins+ , Tereza Cristina de Oliveira Corvelo, Samia Demachki, Marialva TF Araujo, Mônica Baraúna Assumpção, Simone Cristina Araujo Jucá Vilar, Felipe Bonfim Freitas, Hivana Patricia Melo Barbosa, Amanda Alves Fecury, Renata Kelly Costa do

Patients - This study was carried out at Hospital Universitário João de Barros Barreto, Hospital Univer- sitário Betina de Ferro Souza, and Hospital Ofir Loiola from September 2002 to January 2003. During this period, gastric biopsies of 129 consecutive patients (median age, 44 years; range, 15-75 years; 60 women and 69 men) who underwent gastric endoscopy due to different digestive disorders were obtained. None of the patients had re- ceived antimicrobial drugs, H2-receptor antagonists, acid pump inhibitors, nonsteroidal anti-inflammatory drugs, or any medication for at least 60 days before endoscopy.
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The Influence of Small Amounts of Aluminium on the Spheroidization of Cast Iron with Cerium Mischmetal

The Influence of Small Amounts of Aluminium on the Spheroidization of Cast Iron with Cerium Mischmetal

The influence of aluminium (added in quantity from about 0.6% to about 2.8%) on both the alloy matrix and the shape of graphite precipitates in cast iron treated with a fixed amounts of cerium mischmetal (0.11%) and ferrosilicon (1.29%) is discussed in the paper. The metallographic examinations were carried out for specimens cut out of the separately cast rods of 20 mm diameter. It was found that the addition of aluminium in the amounts from about 0.6% to about 1.1% to the cast iron containing about 3% of carbon, about 3.7% of silicon (after graphitizing modification), and 0.1% of manganese leads to the occurrence of the ferrite-pearlite matrix containing cementite precipitates in the case of the treatment of the alloy with cerium mischmetal . The increase in the quantity of aluminium up to about 1.9% or up to about 2.8% results either in purely ferrite matrix in this first case or in ferrite matrix containing small amounts of pearlite in the latter one. Nodular graphite precipitates occurred only in cast iron containing 1.9% or 2.8% of aluminium, and the greater aluminium content resulted in the higher degree of graphite spheroidization. The noticeable amount of vermicular graphite precipitates accompanied the nodular graphite.
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