[PDF] Top 20 14-3-3ε overexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma.
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14-3-3ε overexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma.
... that 14-3-3e expression is in- creased in primary and metastatic ...Elevated 14-3-3e expression is correlated with higher risk of extrahepatic metastasis and lower survival rates ... See full document
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Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition.
... Due to the location of MSCs, TGFb in HCC tissue expression was up-regulated around MSCs at the edge of tumor or tumor stromal ...performed to investigate the expression of EMT markers ... See full document
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Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients.
... data of 10 pairs of in-house samples was preprocessed using GC-RMA method to conduct background correction and ...genes of 20 cases of experimental hepatic samples (10 cancer tissue ... See full document
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Hepatic stellate cells secreted hepatocyte growth factor contributes to the chemoresistance of hepatocellular carcinoma.
... source of extracellular matrix proteins in tumor stroma, hepatic stellate cells (HSCs) have a great impact on biological behaviors of hepatocellular carcinoma ...chemoresistance of ... See full document
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MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA.
... loss of RhoA function through RhoA-T19N largely mimicked miR-122-induced MET, and the inhibition of migration and invasion of tumor cells, whereas RhoA over-expression in miR-122-expressing Bel-7402 ... See full document
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Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition.
... TBP-2 overexpression inhibits proliferation via cell cycle arrest [12,27,28,29] and promotes apoptosis ...responsiveness to IL-2-dependent growth [31], and plays a key role in glucocorticoid-induced cell ... See full document
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Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells.
... metastasis of liver cancer cells. Firstly, insulin- and TGF-b1- induced changes of critical EMT markers such as E-cadherin, ZO- 1, Snail, Zeb1, and vimentin were greatly sensitized by p53 knockdown in liver ... See full document
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Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells.
... Alterations of E-cadherin and N- cadherin mRNA expression in 603B cells after exposure to TGF-b1 for various periods of time as assessed by ...down-regulation of E-cadherin and up-regulation ... See full document
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Foxn1 Transcription Factor Regulates Wound Healing of Skin through Promoting Epithelial-Mesenchymal Transition.
... pool of epithelial cells ...process of EMT although it appears to be orchestrated by similar growth factors, transcription factors, and intracellular signaling pathways characteristic ... See full document
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Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo
... due to block of HLF-1 Figure 2. Effects of pulmonary rehabilitation mixture (PRM) on epithelial-mesenchymal transition (EMT) in high mobility group protein B1 (HMGB1) small ... See full document
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Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition.
... those of Chen et ...number of studies have examined kinase inhibitor amelioration of organ fibrosis [14, 15, ...switching of relevant genes that are critical for EMT in human lung ... See full document
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Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.
... regulation of Elf5 gene is a lineage gate- keeper between the embryonic and trophoblast lineage compartments, as well as between basal and luminal epithelial cells ...barrier of EMT in UC ...criteria ... See full document
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Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a.
... phosphorylation of FOXO3a and subsequently inhibits G1-S transition, through upregulation of the CDK inhibitors p21 Cip1 and p27 Kip1 , while Figure ...panel) of crystal violet-stained cells ... See full document
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A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition.
... miR-200s To identify miRNAs participating in SNAI1-orchestrated regulatory networks, we analysed our time-resolved microarray data (GEO accession: GSE35074) of EMT, triggered by conditional expression ... See full document
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14-3-3ε Is required for germ cell migration in Drosophila.
... capable of producing an interfering RNA (RNAi), and obtained multiple lines capable of abrogating the endogenous D14-3-3e ...due to its highest efficacy (Fig S1B), but results were also ... See full document
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Inhibition of pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04.
... translocation of SMADs proteins in HLECs. As we known, beside SMAD2/3/4 nuclear translocation, TGF-b receptor-induced responses are mediated through numerous signaling pathways, such as TGF-b-induced Erk ... See full document
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A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition.
... analysis of molecular networks is a promising strategy for making individual risk predictions and treatment decisions in cancer ...network of a cell to be reconstructed from clinical gene expression ... See full document
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Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells.
... Induction of EMT-like features by immune cells has been shown in other ...able to induce ...80% of patients with relapsed breast cancer, induce hallmarks of EMT in vitro but show concurrent ... See full document
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Mechanisms of RON-mediated epithelial-mesenchymal transition in MDCK cells through the MAPK pathway
... The epithelial-mesenchymal transition (EMT) is involved in neoplastic metastasis, and the RON protein may be ...mechanisms of action of RON in EMT in Madin-Darby canine kidney (MDCK) ... See full document
9
miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer.
... drivers of the EMT ...maintenance of EMT in a murine mammary carcinoma model; specifically, it has been shown that activation of NF-kB signaling promoted EMT in the absence of TGF-beta, ... See full document
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