Top PDF The effect of autologous platelet rich plasma in treatment lateral epicondylitis

The effect of autologous platelet rich plasma in treatment lateral epicondylitis

The effect of autologous platelet rich plasma in treatment lateral epicondylitis

Sonuç olarak elde edilen bu sonuçlar ile oto- log TZP enjeksiyonun lateral epikondilitte iyi yönde etkinliğinin zamanla artığı söylenebilir fakat pahalı ve daha invaziv olan bu yöntemin etkinliğinin daha iyi anlaşılabilmesi için bizim çalışmamızın da eksik yönü olan olgu sayısı ve takip süresi artırılarak yeni çalışmalar yapılmalıdır. Daha uzun dönem takip- lerde iyi yöne etkinliği saptanması halinde lateral epikondilit tedavisinde klinik kullanımı yaygınlaşa- bilir.

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Platelet Rich Plasma: What should the rheumatologist expect?

Platelet Rich Plasma: What should the rheumatologist expect?

with an history of shoulder pain for >3 months, with the aim to investigate the effect of PRP injections on pain and shoulder functions, in patients with chronic RCT on a standard exercise program. The injections were ultrasound-guided in subacromial space directly into the rotator cuff tendon. The solution, adminis- trated in covered syringes, was injected into the centre of the lesion and 4 sites around the lesion through 1 skin portal. The authors reported that a single injec- tion of PRP was not superior to saline injection in the treatment of chronic RCT and, although effective in im- proving quality of life, pain, disability, and shoulder range of motion, at 1-year of follow-up, this improve- ment did not differ from that seen in the placebo group 31 . Still, Rha et al. showed that PRP injections pro-
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Efeito analgésico do plasma rico em plaquetas e células-tronco na dor crônica de cães com displasia coxofemoral

Efeito analgésico do plasma rico em plaquetas e células-tronco na dor crônica de cães com displasia coxofemoral

2. Carneiro MO, Barbieri CuH, Neto JB. Platelet-Rich Plasma gel promotes regeneration of articular cartilage in knees of sheeps. Acta Ortop Bras. 2013;21. 3. Vilar JM, Morales M, Santana A, et al. Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs. BMC Vet Res. 2013;9.

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Effectiveness of Agents Like Platelet-rich Plasma,  Oxidized Regenerated Cellulose and Microfibrillar  Collagen in Hard-tissue Healing: Validation of  t heir Comparative Effectiveness

Effectiveness of Agents Like Platelet-rich Plasma, Oxidized Regenerated Cellulose and Microfibrillar Collagen in Hard-tissue Healing: Validation of t heir Comparative Effectiveness

Autologous platelet-rich plasma (PRP) can be a valid agent that is effective in inducing and accelerating bone healing for the treatment of periodontal defects and also to accelerate alveolar bone regeneration. Early healing appeared to be impaired by the presence of microibrillar collagen (MFC) and impeded by the presence of oxidized regenerated cellulose (ORC). In contrast, alkylene oxide copolymer (AOC) did not inhibit bone healing and suggest that AOC may be a better bone hemo- static material for procedures where bony fusion is critical and immediate hemostasis required.
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A manual method to obtain platelet rich plasma

A manual method to obtain platelet rich plasma

22. Floryan KM, Berghoff WJ. Intraoperative use of autologous platelet-rich and platelet-poor plasma for orthopedic surgery patients. AORN J. 2004;80(4):668-74. 23. Listl S, Tu YK, Faggion CM Jr. A cost-effectiveness evaluation of enamel matrix derivatives alone or in conjunction with regenerative devices in the treatment of periodontal intra-osseous defects. J Clin Periodontol. 2010;37(10):920-7. 24. Deuel TF, Huang JS. Platelet-derived growth factor. Structure, function, and

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Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

Chronic cutaneous lesions affect 15% of diabetic human patients and represent a risk 15 to 46 times larger of limb amputations compared to people with normal glycemia. It is assumed that half of these amputations could be prevented by early treatment of wounds, for example, with proper cell therapy. Objectives: In this study, the action of the autologous transplant of mesenchymal stem-cells (MSC) was evaluated compared to the treatment with autologous platelet rich plasma (PRP) in the cicatrization of cutaneous lesions induced in diabetic mice. These animals were previously treated with streptozootocin to induce dia- betes mellitus and round wounds of 1.5cm in diameter were created in the posterior region. Diameters of the wounds and healing time were evaluated during 30 days and the results were submitted to variance analysis and Tukey’s test average. It was noticed that the ani- mals treated with MSC presented a more accelerated cicatrization of the cutaneous lesion than the animals treated with PRP. However, the treatment with PRP presented better re- sults than just the daily asepsis of the lesions with saline or covering them with semi-per- meable bandage. Besides, the use of semi-permeable bandage kept the cutaneous lesions of diabetic mice did not interfere negatively with cicatrization, proved to be harmless to use, but kept the cutaneous lesions more hydrated than the ones exposed to the environment. INDEX TERMS: Cutaneous lesion, cicatrization, wound healing, mesenchymal stem cells, diabetes mellitus.
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PLATELET-RICH PLASMA (PRP) AND ITS APPLICATION IN THE TREATMENT OF CHRONIC AND HARD-TO-HEAL SKIN WOUNDS. A Review.

PLATELET-RICH PLASMA (PRP) AND ITS APPLICATION IN THE TREATMENT OF CHRONIC AND HARD-TO-HEAL SKIN WOUNDS. A Review.

reduction of growth factors in chronic wounds is demon- strated in numerous reports as a result of their reduced pro- duction and release, sequestration, or degradation. These mechanisms can be combined [30]. Platelet aggregation has a clearly expressed effect in the process of skin wound heal- ing. In this process, growth factors are released and, adhe- sion of molecules and lipids is observed, while they are re- sponsible for the regulation of cellular migration, prolifera- tion and function of keratinocytes, fibroblasts, and endothe- lial cells [6]. Platelets secrete several antimicrobial peptides when activated by thrombin. PRP has an important antimi- crobial and immunoregulatory activity obtained from leukocytes [31]. A review of studies using different prod- ucts rich in platelets demonstrates significant improvement in the treatment of chronic wounds. Carter et al. performed a meta-analysis of articles for chronic wounds and support the idea that the use of platelet rich plasma favors full heal- ing compared to control groups [5]. In a study by Villela et al., they reached similar conclusions, with one of their con- clusions reaching so far as to conclude that PRP is the method of choice for the treatment of wounds [29]. Anitua et al. presented an open and randomized study to evaluate the effect of PRP in chronic ulcers of 14 patients. They re- ported good healing response in 80% of the cases after 8 weeks of treatment, compared with 20% in the control group. Leukocytes were not detected in the analyzed prod- ucts. Their explanation for the good results lies in the high concentrations of growth factors [30]. Crovetti et al. moni- tored the evolution of chronic skin wounds in 24 patients treated with autologous or homologous gel (depending on the case) and observed a complete healing in 9 of them af- ter an average of 10 applications, with a reduction of pain in all cases [27]. Marté-Mestre et al. reported the recovery of vascular chronic ulcers with the use of PRP in 12 of 14 patients for an average treatment period of 2.93 months (av- erage of 0.5 - 7 months) [29]. Margolis et al. found in a retrospective group study with neuropathic wounds in dia- betic feet greater efficiency in the use of PRP against the conventional therapies, with a more obvious effect in severe wounds [29].
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Rev. bras. ortop.  vol.51 número1

Rev. bras. ortop. vol.51 número1

Objective: To evaluate the effects of platelet-rich plasma (PRP) infiltration in patients with lateral epicondylitis of the elbow, through analysis of the Disabilities of the Arm, Shoulder and Hand (DASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaires. Methods: Sixty patients with lateral epicondylitis of the elbow were prospectively random- ized and evaluated after receiving infiltration of three milliliters of PRP, or 0.5% neocaine, or dexamethasone. For the scoring process, the patients were asked to fill out the DASH and PRTEE questionnaires on three occasions: on the day of infiltration and 90 and 180 days afterwards.
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Platelet activation: Ultrastructure and morphometry in platelet-rich plasma of horses

Platelet activation: Ultrastructure and morphometry in platelet-rich plasma of horses

This study was conducted to investigate the activation ability of the platelet-rich plasma (PRP) by pharmacological agents, as well as to verify the need or not of this activation for therapeutic use. The PRP was obtained from four healthy crossbred geldings aged 13 to 16 years (15±1years), and was processed for observation and quantiication of the platelet morphology by using the transmission electron microscopy. All PRP samples were activa- ted with 10% calcium chloride (CaCl 2 ) solution, pure bovine thrombin or associated with CaCl 2 . The control (pure PRP) was not pharmacologically activated. In the pure PRP sam- ples, 49% of the platelets were classiied as state of activation uncertain, 41% as resting, 9% as fully activated and 1% as irreversibly damaged. Treatment with 10% CaCl 2 provided a distribution of 54% platelets in state of activation uncertain, 24% as fully activated, 20% as resting, and 2% as irreversibly damaged. The platelet morphology of the bovine throm- bin treated samples did not it into classiication adopted, as showing irregular shape with emission of large ilamentous pseudopods, appearance of ruptured and whole granules in the remaining cytoplasm and extracellular environment. There was effect of the treatment on the platelet morphology (P=0.03). The 10% CaCl 2 is an adequate platelet-activating agent. However, in cases the use of PRP under its liquid form is necessary, the use of pure PRP is recommended, since besides presenting an adequate percentage of fully activated platelets it also has signiicant amount of the resting type, which can be activated by subs- tances found in the injured tissue.
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Efeito do plasma rico em plaquetas pré ou pós inseminação artificial sobre a resposta inflamatória e índice de fertilidade em éguas susceptíveis a endometrite persistente pós-cobertura

Efeito do plasma rico em plaquetas pré ou pós inseminação artificial sobre a resposta inflamatória e índice de fertilidade em éguas susceptíveis a endometrite persistente pós-cobertura

The persistent breeding-induced endometritis (PBIE) is the main cause of decrease fertility in the horses, thereby causing significant impact in the horse’s market. The treatments commonly used for PBIE view only minimize the predisposing factors and do not act directly in the inflammatory process. Aiming to reduce the inflammatory response, recent studies have shown an increase in fertility of animals with PBIE when used immunomodulatory agents. A modulator of the inflammatory response that has been largely used in veterinary medicine is the platelet-rich plasma (PRP). This platelet concentrate contains many growth factors which act directly on inflammatory mediators, reducing process and promoting tissue repair. Several studies have shown that PRP is beneficial in the treatment of osteoarticular and tendon inflammations, modulating inflammation and accelerates the regeneration of injured tissue. More recently some researchers have demonstrated the beneficial effect of PRP in intrauterine treatment of mares. Thus, the present study aimed to do a literature review on the aspects related to PBIE, as well as the PRP and its mechanism of action.
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The use of platelet rich-plasma in Ophthalmology: a literature review

The use of platelet rich-plasma in Ophthalmology: a literature review

The aim of this review is to list the ophthalmological conditions in which platelet concentrate (CP) has been used, as well as its bioche- mical and physiological properties. The CP has both anticatabolic potential, present in autologous serum, and substances with anabolic properties, which together are responsible for its benefits in the treatment of ocular surface diseases. There is currently a shortage of clinical trials in this area, both in ophthalmology and other medical areas, with more studies and reports on the use of autologous serum. In ophthalmology, CP has been used in the treatment of symptomatic dry eye, corneal ulcers and ocular burns, among other applications, being an effective alternative in several ocular pathologies; therefore, it’s evident the importance of more studies in this topic to prove the efficiency of this product.
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Aplicação de fatores de crescimento no tratamento de lesões musculotendinosas: Solução ou Ilusão?

Aplicação de fatores de crescimento no tratamento de lesões musculotendinosas: Solução ou Ilusão?

Background: Muscle and tendon injuries are very common in athletes and there is an intensive research to find new treatments that allow an earlier recovery. This justifies the interest in therapies with growth factors, with the aim of accelerate the tissue healing. The platelet-rich plasma (or plasma rich in growth factors) is a fraction of autologous blood obtained by centrifugation, with a platelet concentration higher than the physiological. The aim of this review is to evaluate the clinical and/or imaging outcomes of this therapy in the treatment of the most frequent tendinopathies (patellar, Achilles, rotator cuff and elbow tendinopathies) and in muscle injuries. We also intend to analyze the potential side effects and the possible influence of external factors.
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Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation

Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation

Apexogenesis represents the real clinical challenge in current dentistry since it is of essential significance for complex dental prognosis. Recent investigations are oriented to regenerative methods since the treatment with previous medicaments did not lead to stimulation of pulp tissue regeneration as a source of target stem cells responsible for the process of apexogenesis. The principle of regenerative medicine is to mimic physiological events of development, so we treated the injured pulp directly with an increased concentration of growth factors with the aim to preserve pulp vitality by self- regeneration and by self-protection indirectly by stimulating odontoblasts to produce a reparative barrier, thereby to stimulate apexogenesis. One of the main beneficial characteristics of PRP is their autologous origin with complete biocompatibility which excludes additional inflammatory reactions to exogenous material that could potentially move the regeneration into an excessive direction.
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Why Basic Calcium Phosphate Crystals Should Be Targeted In the Treatment of Osteoarthritis

Why Basic Calcium Phosphate Crystals Should Be Targeted In the Treatment of Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis and results in signiicant social, psychological, and economic costs. It is characterised by progressive cartilage loss, bone remodelling, osteophyte formation, and synovial inlammation with resultant joint pain and disability. Since OA afects the entire joint, it is not surprising that there has been diiculty developing an efective targeted treatment. Treatments available for structural disease modiication are limited. Current options appear to mostly reduce symptoms. Basic calcium phosphate (BCP) crystals represent a potential therapeutic target in OA; they have been found in 100% of knee and hip cartilages removed at joint replacement. Intra-articular BCP crystals are associated with large joint efusions and dissolution of intra-articular structures, synovial proliferation, and marked degeneration as assessed by diagnostic imaging. While BCP deposition has been considered by many to be simply a consequence of advanced OA, there is substantial evidence to support BCP crystal deposition as an active pathogenic mediator of OA. BCP crystals exhibit a multiplicity of biologic efects in vitro including the ability to stimulate mitogenesis and prostaglandin, cytokine, and matrix metalloproteinase (MMP) synthesis in a number of cell types including macrophages, synovial ibroblasts, and chondrocytes. BCP crystals also contribute to inlammation in OA through direct interaction with the innate immune system. Intra-articular BCP crystals can elicit synovial inlammation and cartilage degradation in mice in vivo. Although intra-articular BCP crystals are diicult to detect at the bedside, advances in modern technology should allow improved identiication and quantitation of BCP crystals. Our article focuses on why basic calcium crystals are important in the pathogenesis of OA. There is ample evidence that BCP crystals should be explored as a therapeutic target in OA.
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Rev. bras. ortop.  vol.50 número1

Rev. bras. ortop. vol.50 número1

Shockwave treatment is an option within orthopedics. The exact mechanism through which shockwaves function for treating musculoskeletal diseases is unknown. The aim of this study was to make a qualitative analysis on the effectiveness of shockwave treatment among patients with musculoskeletal pathological conditions and pseudarthrosis. Searches were conducted in the Cochrane Library, Medline and Lilacs databases. Thirty-nine studies that reported using shockwave treatment for musculoskeletal diseases were found. Their results varied greatly, as did the types of protocol used. The studies that evaluated the effectiveness of shockwave treatment for lateral epicondylitis, shoulder tendinopathy, knee osteoarthro- sis, femoral head osteonecrosis and trochanteric bursitis reported inconsistent results for most of their patients. Those that evaluated patients with calcifying tendinopathy, plantar fasciitis, Achilles tendinopathy, patellar tendinopathy and pseudarthrosis showed benefits. Shockwave treatment is a safe and non-invasive method for chronic cases in which conven- tional techniques have been unsatisfactory and should be used in association with other treatment methods for tendinopathy. Further quality studies are needed.
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Rev. Bras. Hematol. Hemoter.  vol.39 número3

Rev. Bras. Hematol. Hemoter. vol.39 número3

The existing techniques to evaluate hemostasis in clinical laboratories are not sensitive enough to detect hypercoagulable and mild hypocoagulable states. Under different exper- imental conditions, the thrombin generation test may meet these requirements. This technique evaluates the overall balance between procoagulant and anticoagulant forces and has provided new insights in our understanding of the coagulation cascade, as well as of the diagnosis of hypocoagulability and hypercoagulability conditions. Thrombin generated in the thrombin generation test can be quantified as platelet-rich or platelet-poor plasma using the calibrated automated thrombogram method, which monitors the cleavage of a fluorogenic substrate that is simultaneously compared to the known thrombin activity in a non-clotting plasma sample. The calibrated automated thrombogram method is an open system, in which different antibodies, proteins, enzymes and peptides can be introduced to answer specific questions regarding hemostatic processes. The thrombin generation test has great clinical potential, such as in monitoring patients taking anticoagulants and antiplatelet drugs, screening for genetic or acquired thrombotic disorders, and evaluating bleeding risk control in patients with hemophilia using bypass agents or replacement therapy. Different to conventional coagulation tests, the thrombin generation test can be used for an overall evaluation of hemostasis, the results of which can then be used to evaluate specific char- acteristics of hemostasis, such as prothrombin time, activated partial thromboplastin time, and levels of fibrinogen and other coagulation factors. The introduction of this method will contribute to a better understanding and evaluation of overall hemostatic processes; however, this method still requires standardization and clinical validation.
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Maxillary alveolar bone grafting: the role of Platelet-rich plasma (PRF)

Maxillary alveolar bone grafting: the role of Platelet-rich plasma (PRF)

Saeedeh Khajehahmadi, Assistant Professor of Oral and Maxillofacial Pathology , Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Scie[r]

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Braz. oral res.  vol.23 número3

Braz. oral res. vol.23 número3

Evaluation of the standardized digital radio- graphic images showed that one month after surgery, most of the defects in which PRGF was applied were either partially (50%) or completely illed (37.5%), while in the control group most of the defects re- mained partially vacant (62.5%). The differences were statistically signiicant. After two months, the PRGF treated defects showed a greater percent- age of radiographically manifest bone regeneration (66.67%), though without statistically signiicant differences (Table 1).
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Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats

Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats

due to ensure the standardization. After asepsi a 3 cm midline incision was made and the descending colon was mobilized. The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures (Figure 1). In order to compare the effects; of PRP and fibrin glue applied on anastomotic line and rats diveded into 3 groups( 12 rats in each group) according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The median incision was closed with a 3/0 polypropilen sutures. In the post-operative period, no antibiotics were given to the rats. Oral food was started on the post-operative first day. On postoperative day 7 all animals were euthanized by intraperitoneal overdose of 2 ml pentobarbital sodium (175mg/ml, KU Life, Copenhagen, Denmark). After the sacrification, the rat fascia was opened and the anastomosis was achieved by carefully dissecting the adhesions.
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The modification process of AlSi21CuNi silumin and its effect on change of mechanical properties of the alloy

The modification process of AlSi21CuNi silumin and its effect on change of mechanical properties of the alloy

Essence of modification of silumins boils to change of form or size of silicon crystals present as eutectic or primary ones. Perfect sliding properties and high abrasion resistance of hypereutectoid silumins result from their structure, which can be characterized by precipitations of primary crystals of silicon in soft eutectic groundmass. Primary crystals of silicon are unfavorable due to their impact on machinability of material. They bring about considerable wear of tools and have negative effect on conditions of machined surface (big roughness). In case of hypereutectic silumins, by introduction of active nucleuses of crystallization are refined mainly a brittle, hard precipitations of primary silicon [1]. High content o silicon results in necessity of superheating of the alloy in limits of 850 – 900 C and keeping it
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