[PDF] Top 20 Effect of Natural Polymorphisms in the HIV-1 CRF02_AG Protease on Protease Inhibitor Hypersusceptibility
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Effect of Natural Polymorphisms in the HIV-1 CRF02_AG Protease on Protease Inhibitor Hypersusceptibility
... HS-linked polymorphisms 17E and 64M had higher rep- licative fitness than did viruses harboring either 17E or 64M and that these mutant viruses showed a higher fitness than did the parental ...that ... See full document
7
Natural Polymorphisms Conferring Resistance to HCV Protease and Polymerase Inhibitors in Treatment-Naive HIV/HCV Co-Infected Patients in China.
... emergence of novel therapeutics for chronic hepatitis C virus (HCV) infection has brought this global pandemic to the forefront of public health attention ...with HIV is common in HCV ... See full document
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The effect of an HIV-1 viral protease inhibitor on staurosporine-induced apoptosis in immortalized mesangial cells
... The effect of the HIV-1 protease inhibitor Ac-Leu-Val-phenylalanine (PI; Calbiochem, CA, USA) on the rate of staurosporine-induced apoptosis ... See full document
3
Potential elucidation of a novel CTL epitope in HIV-1 protease by the protease inhibitor resistance mutation L90M.
... frequencies of L90M could be observed in PR sequences obtained from patients that are positive specific HLA ...to the collection of sequences obtained from various patients. The ... See full document
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Randomized trial of time-limited interruptions of protease inhibitor-based antiretroviral therapy (ART) vs. continuous therapy for HIV-1 infection.
... While the results from the present and other studies conducted in resource-constrained countries overall do not support intermittent ART as a routine treatment strategy, treatment interruptions ... See full document
9
Low accumulation of L90M in protease from subtype FHIV-1 with resistance to protease inhibitors is caused by the L89M polymorphism
... genotype in the subtype F back- bone, at a frequency of ! ...Nevertheless, the subtype F isolates from treated individuals described here as carrying the L90M re- sistance mutation have ... See full document
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HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil
... Adults on ARV treatment failure in Paraná, Brazil, with genotyping tests from 2002 to 2006 were ...part of routine clinical care and indicated when a patient on ART presented virologic ... See full document
12
Visualization of early events in acetic acid denaturation of HIV-1 protease: a molecular dynamics study.
... calculation on the two trajectories [Figure 4(a) and 4(b)] reveals that even in the denaturing 9 M AcOH conditions, much residual secondary structure mainly as the b-sheet remains ... See full document
7
Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer.
... Figure 1. Meprin promotes migration and angiogenesis in vitro ...cultured on laminin 1-coated dishes and exposed to HGF (20 nM) to induce migration in the absence or presence ... See full document
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Substrate-driven mapping of the degradome by comparison of sequence logos.
... proteases in an effort to rationalize selectivity of grassystatins A-C [68], thus providing broad bioactivity data for these three ...our protease specificity tree (see Figure ...groups in ... See full document
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UNIVERSIDADE FEDERAL DO PARÁ NÚCLEO DE MEDICINA TROPICAL PROGRAMA DE PÓS GRADUAÇÃO EM DOENÇAS TROPICAIS Luiz Henrique Campos Holanda
... da protease devido as características da mutação M46I, trazendo de volta a estrutura da enzima à sua conformação ...de protease, mas também acabam interferindo na própria interação com a clivagem das ... See full document
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A Chlamydomonas-derived Human Papillomavirus 16 E7 vaccine induces specific tumor protection.
... screening of transformants to identify the best expressor lines, 2610 6 ...re-suspended in a suitable volume of loading buffer (10% glycerol, 60 mM Tris-HCl pH ...loading on a 12% ... See full document
9
Isolation, purification and characterization of extracellular protease produced by marine-derived endophytic fungus Xylaria psidii KT30
... pH of 4 or 10. Surprisingly, the activity of enzyme remained above 50% when pH was increased from 7 to ...tremendous effect on protease activity; meanwhile EDTA gave only mild ... See full document
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Clinical and Biochemical Evaluation of HIV-Related Lipodystrophy in an Ambulatory Population from the Hospital Universitário Cassiano Antonio de Morais, Vitória, ES, Brazil
... tertiary HIV-care center (Hospital Universitário Cassiano Antonio de Morais) in Vitória, ES, ...by the university hospital laboratory (cholesterol levels, triglycerides, glucose) and by LACEN – State ... See full document
5
Trypsin-like serine proteases in Lutzomyia longipalpis--expression, activity and possible modulation by Leishmania infantum chagasi.
... loaded in the gel in non reducing buffer (125 mM Tris pH ...4uC. The gels were washed in ...during 1 hour to remove SDS. To test for best conditions, proteolysis of ... See full document
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Protease encapsulation: effect of particle composition and size on enzymatic reuse / Encapsulação de protease: efeito da composição e tamanho de partículas na reutilização enzimática
... reuse of the biocatalyst is only possible when stability is maintained, which can be achieved by immobilization (ANWAR et ...consists of the confinement of the protein in ... See full document
10
The impact of the nelfinavir resistance-conferring mutation D30N on the susceptibility of HIV-1 subtype B to other protease inhibitors
... to the International AIDS Society panel of HIV-1 DRM, the D30N mutation is considered a ma- jor mutation for NFV and it confers a significant loss of susceptibility to this drug ... See full document
5
Protease Gene Shuffling and Expression in Pichia pastoris
... and the transformants were selected on LB plates containing ...mg/mL). The transparent zone was used as an indicator of protease ...activity. The colonies with the largest ... See full document
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The Impact of the Expansion of the Bolsa Familia Program on the Time Allocation of Youths And Their Parents Lia Chitolina Miguel Nathan Foguel Naercio Menezes-Filho
... As the multinomial model is non-linear, the marginal effect of the treatment in a DID model is not the marginal impact of the interaction between time and ... See full document
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Endosymbiotic and host proteases in the digestive tract of the invasive snail Pomacea canaliculata: diversity, origin and characterization.
... made in 10% polyacrylamide gels that were copolymerized with gelatin (Sigma G7765; 1 mg/mL) and 75 mg of the extracted protein were loaded per lane and electrophoresis was run at 4 uC under ... See full document
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