Top PDF THE EFFECTS OF POOR GLYCEMIC CONTROL AND OF NON-SURGICAL PERIODONTAL THERAPY IN PATIENTS WITH DIABETES MELLITUS

THE EFFECTS OF POOR GLYCEMIC CONTROL AND OF NON-SURGICAL PERIODONTAL THERAPY IN PATIENTS WITH DIABETES MELLITUS

THE EFFECTS OF POOR GLYCEMIC CONTROL AND OF NON-SURGICAL PERIODONTAL THERAPY IN PATIENTS WITH DIABETES MELLITUS

Aim: The aim of the study was to evaluate the relationship between the diabetic status and severity of the periodontal involvement, and also of the non-surgical periodontal therapy on the periodontal status of patients with diabetes mellitus. Materials and method: The study was conducted on 21 patients with type 1 diabetes mellitus (study group) and 10 systemically healthy subjects (control group). We examined: the degree of glycemic control (by measuring the glycated hemoglobin), the periodontal and oral hygiene parameters at the baseline and 4 weeks, 6 months and 12 months after the periodontal treatment (scaling and root planning). Results and discussion: Subjects with a poor glycemic control presented a higher percentage of sites with attachment loss, signiicantly higher amounts of bacterial plaque, sub-gingival calculus and gingival bleeding - when compared with the control group or with subjects with good or moderated glycemic control. In the same group, a rapid recurrence of the deep periodontal pockets was observed after 12 months. Conclusions: A prolonged poor control of glycemia and the time elapsed from the debut of diabetes were closely related with its complications. The comparison between the diabetes and the control groups demonstrated that diabetes mellitus is a risk factor for the periodontal disease.
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Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia

Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia

Class of antidiabetic agents alpha-glucosidase inhibitor, acarbose was significantly associated with the moderate non-proliferative diabetic retinopathy (NPDR). Acarbose used was strongly and significantly associated with presence of moderate NPDR as shown in study. Animal study showed that, acarbose use might lessen the effect on the development of retinopathy in Zucker Diabetic Fatty rats (Yang et al., 2000). On the other hand, a study showed, acarbose was associated with positive effect of postprandial hyperglycemia (Derosa, Maffioli, 2012). Moreover, two cohort studies agreed that, increase in postprandial plasma glucose was associated with increasing risk of progression of diabetic retinopathy (DR) (Mannucci et al., 2012). Therefore, acarbose might possibly indirectly cause reduction in the risk of progression of DR due to its efficacy proven in reduction of postprandial plasma glucose. However, the result of this study was varied from the finding in those studies. This was probably due to small sample size and the results cannot be generalized as there was only 10.6% of patients took alpha-glucosidase inhibitor antidiabetic agents as combination therapy.
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Depressive symptoms are associated with poor glycemic control among women with type 2 diabetes mellitus

Depressive symptoms are associated with poor glycemic control among women with type 2 diabetes mellitus

While waiting for their diabetes consultation, patients were approached and selected by trained clinical psy- chologists taking into account the inclusion criteria. Eligi- ble patients were consecutively invited to participate and those who accepted were given a brief explanation about the negative influence of the comorbidity between dia- betes and depression on health outcomes. Socio-demo- graphic and clinical data, namely body mass index (BMI), HbA1c level, diabetes type, therapy and antidepressant medication, were collected. Chronic complications (retin- opathy, nephropathy, neuropathy and cardiovascular) due to diabetes were identified from the patient’s medical his- tory, physical findings and automated laboratory data.
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Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.

Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.

pancreatic fibrosis [28]. On the basis of these reports, the adverse effects of cigarette smoking on glycemia seem to be mediated through both insulin resistance and impaired insulin secre- tion. In this study, HOMA2-IR levels showed a dose-response relation with the increasing amount of smoking (Table 5). Estimates of insulin resistance derived from HOMA is an indi- rect parameter compared with glucose clamp tests, a golden standard. However, it may be ap- propriate for use in large epidemiological studies [29], attributable to its simple and convenient nature. This use in diabetic patients showed a strong correlation with the insulin resistance index assessed by euglycemic–hyperinsulinemic clamp (r = −0.725, P <0.0001) [30]. Another study also showed a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = −0.820, P <0.0001) in subjects including diabetic pa- tients, with no substantial difference between nondiabetic (r = −0.754) and diabetic patients (r = −0.695) [31]. Though the cautious interpretation is needed, the use of HOMA model in subjects treated by insulin or insulin secretagogues may be applicable [29]. Some prior studies reported the relationship between smoking and insulin resistance, but the results were incon- sistent [10,11,18,26]. In an experimental study among 40 healthy volunteers [18], smokers pre- sented higher plasma insulin concentrations in response to oral glucose load despite similar glucose concentrations, and higher steady-state plasma glucose concentration compared with never smokers. The smoking-insulin resistance association was also observed in diabetic pa- tients in earlier studies, though the numbers of subjects were relatively small (40 [10] and 52 patients [11], respectively). In contrast, another community-based cross-sectional study in Sweden showed no association between smoking status and insulin resistance [26]. The dose- response relationship of our study
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J. Appl. Oral Sci.  vol.21 número1

J. Appl. Oral Sci. vol.21 número1

Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. 80- Sandberg GE, Sundberg HE, Fjellstrom CA, Wikblad KF[r]

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An Analysis Of The Difference In Gender Level Of Cassava Production And Access To Land In Abia State Nigeria

An Analysis Of The Difference In Gender Level Of Cassava Production And Access To Land In Abia State Nigeria

technique was employed in sample selection. In the first stage, the three agricultural zones in the state were purposively selected. Aba, Umuahia and Ohafia. In the second stage three local governments actively involved in agricultural production was purposively selected from each of the agricultural zone making it a total of nine blocks. While In the third stage two communities was randomly selected from each of the local government. Twelve respondents was randomly selected from two sampling group. six each for male and female giving twelve respondents from each cell. A total of 218 respondents was selected for the study. The research instrument used for this study was structured questionnaire and scheduled interview. The result of the objective of the study was analyzed using descriptive statistics such as frequency, percentage, and mean inferential which involves the use of Z-test analysis. The formula used to compute the mean used in this study is specified below. The mean was computed by multiplying the frequency (f) of the responses under each response category by assigned value and dividing the (∑) of the product by the (N) no of respondents to the particular indicator as shown:
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The Existence Of Leading Islands Securing And The Border Areas Unitary State Of Indonesia An Analysis In Law Perspective

The Existence Of Leading Islands Securing And The Border Areas Unitary State Of Indonesia An Analysis In Law Perspective

www.ijstr.org can support the management of coastal areas, so it can be arranged on the setting, management, utilization, preservation and protection and security of marine areas and determination of Indonesia‘s borders area. To be comprehend the existence of territory of a country that called as maritime country in which it consists of securing a territorial waters, leading islands and natural resources outcomes such as fishing become rights and obligations of all government and relevant agencies to handle the management of coastal areas and leading small islands of various foreign ships or parties that violate a cross-border waters the other party‘s interests that can threaten the state‘s sovereignty.
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Comparison of diabetes management status between cancer survivors and the general population: results from a Korean population-based survey.

Comparison of diabetes management status between cancer survivors and the general population: results from a Korean population-based survey.

Despite these limitations, our finding that cancer survivors had a suboptimal diabetes management status compared to that of the non-cancer chronic disease group suggests there is room for improvement in the management of diabetes in cancer survivors. Taking this into consideration, the additional finding that the prevalences of treatment and adequate glycemic control were lower in cancer survivors compared with the non-cancer, chronic disease group, despite greater awareness of diabetes in the cancer survivors, strongly indicates that there are certain barriers to adequate diabetes management in cancer survivors. Our findings illustrate the issues with the health care system for cancer survivors in Korea, in terms of the ambiguity in care responsibility between oncologists and PCPs. Inadequate glycemic control in cancer survivors could lead to severe cardiovascular or oncogenic consequences, and special attention to diabetes management and proactive education is needed to ensure that survivors receive optimal diabetes care. Regardless of who is responsible, general primary care issues, including glycemic control in cancer survivors, should be addressed with greater priority. Further studies in this area are warranted to determine the optimum roles of primary care and specialist physicians.
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Assessment Of Some Acceleration Schemes In The Solution Of Systems Of Linear Equations.

Assessment Of Some Acceleration Schemes In The Solution Of Systems Of Linear Equations.

Many practical problems can be reduced to systems of linear equations Ax = b, where A, b are known matrices and x is a vector of unknowns. Systems of linear equations play a prominent role in economics, engineering, physics, chemistry, computer science and other fields of Pure and Applied Sciences [2]. A solution to a system of linear equations is a set of numerical values ….. that satisfies all the equations in a system [1]. There are two classes of iterative methods [3]: linear stationary and linear nonstationary. The stationary iterative methods are the Jacobi, Gauss-Seidel and SOR and Nonstationary include Krylov subspace methods: Conjugate Gradient, Minimal Residual, Quasi-Minimal Residual, Generalizes Minimal Residual and Biconjugate gradient methods. The choice of a method for solving linear systems will often depend on the structure of the matrix A. According to [8] ideally, iterative methods should have the property that for any starting vector , it converges to a solution Ax = b. [5] is of the view that examination of the Jacobi iterative method shows that in general one must save all the components of the vector while computing the components of the vector for an iterative method. According to Hadjidimos [6], the first step in the construction of solution of stationary iterative methods usually begins with splitting of matrix A. Thus, A = M – N where det M and M is easily invertible so that A = b is equivalent to = T + C , where T = and C = giving the iterative scheme = T + C , (k = 0,1,2……). [2] noted that for systems of linear equation A the splitting matrix may be chosen in a different way; that is, one can split matrix A as A = D L U where D is the diagonal matrix, L and U are strictly lower and strictly upper triangular matrices respectively. In solving the systems of linear equations Ax = b, therefore, we consider any convergent method which produces a sequence of iterates { [7] .Quite often the convergence is too slow and it has to be accelerated. According to [9] to improve the convergence rate of the basic iterative methods, one may transform the original system A = b into the preconditioned form PA = Pb, where � is called the preconditioned or a preconditioning matrix. Convergent numerical sequences occur quite often in natural Science and Engineering. Some of such sequences converge very slowly and their limits are not available without suitable convergent acceleration method. Some known acceleration schemes are: Chebyshev Extrapolation scheme [4] and residual Smoothing.
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The application of optical measurements for the determination of accuracy of gear wheels casts manufactured in the RT/RP process

The application of optical measurements for the determination of accuracy of gear wheels casts manufactured in the RT/RP process

Rapid prototyping (RP) and rapid tooling (RT) systems are increasingly used in the production of casting components. RP systems can be used directly for manufacturing casting moulds [1- 9]. The spectrum of rapid prototyping uses can be expanded by the application of the rapid tooling methods. One of the RT techniques is the direct manufacture of casting moulds using the ZCast technology. The accuracy of gear wheels casts made in printed moulds depends on a variety of technological factors [10- 13]. The accuracy of the cast fabrication quality can be assessed with the use of the coordinate optical measuring technique [14- 16]. Literature describes the methods for manufacturing moulds in
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Arq Bras Endocrinol Metab  vol.57 número9

Arq Bras Endocrinol Metab vol.57 número9

Objetivo: Investigar os efeitos do exenatide sobre a glicose sérica, peso corporal e enzimas hepá- ticas em pacientes com diabetes melito tipo 2 (T2DM) e doença hepática gordurosa não alcoólica (DHGNA). Sujeitos e métodos: Um total de 117 pacientes com T2DM e DHGNA foi aleatoriamente separado em dois grupos, um tratado com exenatide e um tratado com metformina. Os pacientes fo- ram tratados por 12 semanas. Resultados: Após 12 semanas de tratamento, o peso corporal, índice de massa corporal (IMC), relação cintura-quadril, HbA1c, FPG, glicose pós-prandial, ALT, AST, γ-GT e proteína C-reativa foram signiicativamente reduzidos, e a relação AST/ALT e a adiponectina aumen- taram marcadamente nos dois grupos. O IMC, relação cintura-quadril, glicose pós-prandial, ALT, AST, γ-GT e proteína C-reativa foram marcadamente menores, e a relação AST/ALT e a adiponectina foram dramaticamente mais altas no grupo tratado com exenatide do que no grupo tratado com metformi- na. Conclusão: Comparado com a metformina, o exenatide controla melhor a glicose sérica, reduz o peso corporal e melhora as enzimas hepáticas, atenuando a DHGNA em pacientes com T2DM de ocorrência concomitante com a DHGNA. Arq Bras Endocrinol Metab. 2013;57(9):702-8
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Rev. Bras. Reumatol.  vol.57 número3

Rev. Bras. Reumatol. vol.57 número3

Resultados: Incluíram-se quatro artigos. O tratamento periodontal não cirúrgico esteve asso- ciado a uma reduc¸ão significativa no DAS-28 (OR: - 1,18; IC 95%: -1,43 a -0,93; p < 0,00001). A velocidade de hemossedimentac¸ão, a proteína C-reativa, a avaliac¸ão da atividade reuma- toide pela escala visual analógica e as contagens de articulac¸ões sensíveis e inchadas apresentaram uma tendência de reduc¸ão (reduc¸ão não estatisticamente significativa). Conclusões: A reduc¸ão no DAS-28 em pacientes com artrite reumatoide após tratamento periodontal sugere que a melhora na condic¸ão periodontal é benéfica a estes pacientes. São necessários mais ensaios clínicos randomizados controlados para confirmar este achado.
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Rev. odonto ciênc.  vol.26 número1

Rev. odonto ciênc. vol.26 número1

Initially, a bivariate analysis was conducted with the purpose of describing the socio-demographic characteristics of the control and experimental groups. Similarly, the clinical characteristics were described before and after periodontal treatment of the experimental group. For this purpose, the McNemar test and Fisher’s Exact test were used to assess the categorical variables. The descriptive analysis of the clinical periodontal characteristics in control group as well as in the experimental group was also conducted before and after therapy. Afterwards, the differences in the reduction of CRP levels were veriied (dependent variable), comparing the irst measurement with the inal one performed after periodontal treatment, using the paired Student’s-t test. To verify the effect of other considered co-variables (BMI, triglycerides, physical activity, HDL and BMI) in reducing C-reactive protein, the multivariate analysis with a linear regression model (ANCOVA) was used. Finally, the C-reactive protein measurements, before and after periodontal therapy, were compared with the experimental group and control group, using the Tukey multiple comparison test. The level of statistical signiicance adopted was 5%. The SPSS version 10.0 and Stata version 7.0 statistical packages were used.
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Renal sympathetic denervation in resistant hypertension

Renal sympathetic denervation in resistant hypertension

Resistant hypertension remains a major clinical problem despite the available multidrug therapy. Over the next decades, its incidence will likely increase given that it is strongly associated with older age and obesity. Resistant hypertension patients have an increased cardiovascular risk, thus effective antihypertensive treatment will provide substantial health benefits. The crosstalk between sympathetic nervous system and kidneys plays a crucial role in hypertension. It influences several pathophysiological mechanisms such as the central sympathetic tone, the sodium balance and the systemic neurohumoral activation. In fact, studies using several animal models demonstrated that the renal denervation prevented and attenuated hypertension in multiple species. Large reductions in blood pressure were also observed in malignant hypertension patients submitted to sympathectomy surgeries. However, these approaches had an unacceptably high rates of periprocedural complications and disabling adverse events. Recently, an innovative non-pharmacological therapy that modulates sympathetic activation has been successfully developed. Renal sympathetic percutaneous denervation is an endovascular procedure that uses radiofrequency energy to destroy the autonomic renal nerves running inside the adventitia of
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Acute and chronic glycemic effects of aerobic training in patients with type 2 diabetes

Acute and chronic glycemic effects of aerobic training in patients with type 2 diabetes

The study has some limitations, such as sample size, which can be considered small; the absence of a group without structured exercise, that is, a control group; and lack of progression of the training variables or of adjustment of intensity, as the proposed intensity for each individual might have become underestimated at a certain moment and trainability status. Another lim- itation is the lack of control of the participants’ eating habits, as what they ate may have influenced the differ- ence that was found between glucose concentrations before the exercise at the beginning and at the end of the 16 weeks. However, the study aimed to analyze acute glycemic effects at different moments of an aer- obic training program, as well as the chronic effect of the same program, which makes it be distinct from a
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Medication adherence in type 2 diabetes mellitus patients: a cross-sectional study

Medication adherence in type 2 diabetes mellitus patients: a cross-sectional study

mographic and psychological variables of our sample. The mean age was 61.3 years (± 13.8 years). The ma- jority were married (76.5%), retirees (62.4%), and stu- died less than nine years at school (84.7%). Only 10.6% of our patients lived alone. The mean duration of dia- betes was 9.8 years (± 7.1 years). The average of diffe- rent medications used by the patient was 4.35 (± 3.12). Arterial hypertension (63.5%), dyslipidemia (45.9%) and obesity (37.6%) were the most common comorbi- dities. Chronic kidney disease was reported by only one patient (1.2%). Depressive symptoms were found in 23.5% of our patients. Stress scale mean levels were 16.9 ± 5.6, ranging from 2.0 to 30.0. Unsatisfactory glycae- mic control (HbA1c > 7%) was found in 32.5% of our pa- tients. The practice of physical exercise more than two times a week was present in 45.9% of our patients. In the lifestyles, we found 7.1% of active smokers and 22.4% with high alcoholic beverages consumption.
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An Analysis of Student Evaluations of Native and Non Native Korean Foreign Language Teachers

An Analysis of Student Evaluations of Native and Non Native Korean Foreign Language Teachers

The most common type of complaint from students was un- questionably related to excessive lecturing on the part of the native TA (about 70% of negative comments related to excessive lecturing, not enough time to talk.) Students often felt shorthanded when not given opportunities to discuss topics in class. (Although this contra- dicts the statements above related to difficult discussion topics, we should assume that students who requested more discussion in class are expecting discussion at an appropriate language level.) One stu- dent said of a native male TA, “I think if there were more opportuni- ties to speak instead of hearing him speak for most of the class, it would have been more beneficial.” Another complained about a na- tive female TA, “She was very enthusiastic about teaching, but activi- ties that actually involved speaking were sparse.” More than anything else, students mentioned discussion in the classroom, and the majori- ty of these complaints and requests were aimed towards native female TAs: “I did not like how little we got to speak as a class. My under- standing increased but I feel my speaking skills went down”; “More class participation would have been good”; “I wish we would have had more opportunities to have class debates and class discussions”; “mostly a lecture [with] little interaction”; “I think the only thing that could be improved is if she would have us speak more in class.” Fi- nally, one student wrote an extensive comment for a female TA that depicted her as an outstanding TA, but then ended with the sugges- tion that “more emphasis on free class discussion might help.”
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Analysis of Structure and Abrasion Resistance of the Metal Composite Based on an Intermetallic FeAl Phase with VC and TiC Precipitates

Analysis of Structure and Abrasion Resistance of the Metal Composite Based on an Intermetallic FeAl Phase with VC and TiC Precipitates

Molten metal with the composition of high-aluminium cast iron was superheated to a temperature of 1510°C, and then samples were cast at 1420°C for metallographic examinations. To thus prepared liquid cast iron, vanadium was next introduced in the form of ferroalloy The titanium to second heat was introduced in figure of scraps of titanic sheet metal. Consequently, cast iron of the chemical composition given in Table 1 was obtained. Samples were poured into dry moulds prepared from the traditional bentonite-bonded sand. From these samples, metallographic specimens were prepared.
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Effect of water glass modification with nanoparticles of zinc oxide on selected physical and chemical properties of binder and mechanical properties of sand mixture

Effect of water glass modification with nanoparticles of zinc oxide on selected physical and chemical properties of binder and mechanical properties of sand mixture

Nanoparticles as a new generation of materials are used in many fields. The basic methods for their preparation are the top- down and bottom-up techniques. The essence of the top-down technique consists in grinding the material to particles with nano dimensions, while the bottom-up technique assumes making structures from molecules or single atoms [1,2]. According to a method recently developed, the nanoparticles of metal oxides are produced through anodic dissolution of metals [3]. There are also thermal methods of obtaining metal nanoxides [4-7].
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A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes.

A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes.

Written informed consent was obtained from each subject’s parent(s) and assent was also obtained from minors. Inclusion criteria were HbA1c >8% (64 mmol/mol) but <14% (130 mmol/mol), BMI >85 th percentile, and T1D >12-month (mo) duration. The initial age of inclusion was 10–18 years (y), however, this was later increased to 20 y to facilitate enrollment (S1 Amendment). The diagnosis of T1D was established by the presence of autoantibodies against islet antigens such as insulin, glutamic acid decarboxylase, and the protein tyrosine phosphatase-like molecule IA-2. Subjects were excluded if they were pregnant or breastfeeding; receiving weight-altering therapies; had recurrent hypoglycemia; systemic illnesses; or had a history of 2 episodes of diabetic ketoacidosis in the preceding 12 mo. Five subjects were excluded based on these criteria (Fig 1). All participants received once-daily subcutaneous basal insulin injections using detemir insulin; and pre-meal bolus insulin injections using insu- lin aspart throughout the study period. All participants were overweight or obese pubertal or post-pubertal subjects with T1D of ages 10–20 y. Fig 1 summarizes the study scheme from chart review through randomization to study conclusion.
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