[PDF] Top 20 The efficacy and safety of natalizumab for the treatment of multiple sclerosis in Portugal: a retrospective study

... comparing the results of the current study with those of a recent similarly- designed Spanish study by Fernandez et al [6] (Ta- ble ...were retrospective, multi- centre, ... See full document

... Las limitaciones del estudio estriban en el riesgo de sesgo inherente a cualquier estudio retrospecti- vo y del potencial de regresión a la media por la au- sencia de un grupo de control. En todo estudio re- trospectivo ... See full document

... used the independent t-test for the comparison between quantitative variables: EDSS at diagnosis, EDSS after one year under DMT, number of relapses prior to diagnosis and number of ... See full document

... patients and the two control groups (IFN-treated patients and HC) in all ex vivo experiments were performed using the non-parametric Mann- Whitney ...to the geometrical mean ... See full document

... within the previous three years with at least one in the previous year, an EDSS score between ...1.0 and 6.0 and at least six T2 lesions on MRI and/or two relapses in ... See full document

... beta. The mechanism of action of this treatment is known to increase this inflammatory marker of macrophage activation ...early in the course of NTZ therapy, plasma ... See full document

... score of 4, family history of MS; 3) laboratorial data: oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF), CSF IgG index, CSF white-cell count, varicella zoster virus and herpes ... See full document

... efficacious in eastern Africa [7] than in Asia [8], but a 17- day treatment with a combination of SSG and PM showed good efficacy and is now recommended as first-line ... See full document

... objective of this study was to compare the safety and ef ficacy of ...gel and dexamethasone topical ointment in the treatment of recurrent ... See full document

... investigating efficacy in SPMS patients in clinical ...improvement in T25FW. In a recent analysis, we showed that consistent worsening of T25FW was the most responsive ... See full document

... Multiple Sclerosis (MS) is a chronic, inflammatory, demyelinating disease associated with progressive neurodegeneration which can be seen as a two phase disease: one early acute inflammatory phase ... See full document

... all of them had just stopped treatment), participation in another study (five patients, who were about to start a clinical trial), and agenda issues (12 ...total of 114 patients ... See full document

... late in the disease evolution; it may be explained by some initial reluctance in NZ prescription, regarding safety concerns, namely ...On the other hand, this may reflect initial ... See full document

... number of toxicities, including nausea/vomiting, diarrhea, fatigue, anorexia, dry skin, hypertension, GI perforation, GI and other bleeding, and thrombosis ...reported in the Phase II ... See full document

... gravidez não planeada é confirmada. No entanto poderão existir exceções a esta regra em casos de doença muito ativa, nos quais que se prevê um risco elevado de surtos durante a gravidez. Entre os TMD, aqueles que têm ... See full document

... expected. In those patients, the presence of symptoms/ limitations can be due to unsuccessful operative correction of flatfoot, inappropriate time between placement and removal ... See full document

... The study was conducted in 3 villages, Magaya, Chipinda and Chitate, in the Mashonaland East Province of Zimbabwe (31 u309E; 17u459S) where ...areas in Zimbabwe, ... See full document

... concentration and without differences among study ...seen in any ...incubated in direct contact with the inner side of human full thickness skin grafts, thus missing out sub- ... See full document

... analyzes the profile of the Brazilian output in the field of multiple sclerosis from 1981 to ...2004. The search was conducted through the MEDLINE ... See full document

... one of the most important causes of death and pain in OECD countries in one hand, and on the other an important financial burden in National Health Systems ... See full document