[PDF] Top 20 Epigenetic biomarkers as predictors of clinical outcomes in colorectal cancer

... located in the first exon of CXorf1 gene is hypomethylated in stage ...is in accordance with survival analysis performed, which showed that low methylation levels are associated with a poor ... See full document

... number of methodological expedi- ents adapted from recent ...performed in plasma since this biological matrix represents a better source of cfDNA than serum [1, ...length of the fragment may ... See full document

... estimation of the survival function during time is analyzed by log-rank statistics and the fraction of patients surviving at each time after surgery and/or treatment is plotted (15, ...16). In ... See full document

... availability of information and heterogeneity in clinical data is inherent to the use of public datasets and this is a major impediment for repeatability and integration of published ... See full document

... findings of this work are of translational relevance because of two aspects: first, Hsp27, systemically, or confined to the tumor stroma, might possess potential prognostic and predic- tive ...option ... See full document

... involved in the oncogenesis of several ...acetylation of SOCS1and SOCS3 in human colorectal cancer cells, and thus helps in preventing cancer (Xiong et ...results ... See full document

... implementation of that kind of personalized medicine still falls short of what was expected a few years ago, the use of targeted therapies has increased in several types of ... See full document

... institution in 2008; physically fit patients with surgically resected CRC, stages II and III were ...aim of this study was to evaluate the rate of surgical treatment of recurrence with ... See full document

... body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and ...aim of this study is to analyze ... See full document

... phenotypes of CRCs remains ...features of CRCs. Alterations of these markers have been shown to be critical events during colorectal carcinogenesis ...observed in S-FN and LST-NG ... See full document

... genomic biomarkers have been used as prognostic and predictive markers to refine the prognostic information of ...potential in identifying sub-network biomarkers (Shi, Beauchamp & Zhang, ... See full document

... discovery of miRNAs in extracellular body fluids strongly increased the number of studies showing deregulated expression of circulating miRNAs in cancer diseases 30 .... ... See full document

... survival of 9.0 months compared with 6.2 months in those receiving 5-FU/leucovorin alone ...noted in this ...result in the patient having to receive a lower dose or shorter course of ... See full document

... involved in CRC and their relationship with treatment ...continuous cancer cell lines, which may not fully represent parent tumors and, therefore, clinical responses to ...teristics of primary ... See full document

... CRC in Spain in which 25 probands i t Amsterdam I or II ...(60%) of the tumors were MSS with the remaining ...difference in synchro- nous or metachronous ...families in the MSS group ... See full document

... Quantiication of human DNA (hDNA) in the feces may be a possible screen non-invasive method that is a consequence of the high proliferation and exfoliation of cancer ...DNA in ... See full document

... changes in prostate cancer are being studied extensively at present and genome wide screening will lead to development of novel epigenetic ...markers. Epigenetic changes are early event ... See full document

... used in colorectal patients, principally during follow up after radical ...prognosis, in som e studies. O b je ctive : T he purpose of this study w as to evaluate the preoperative carcinoem ... See full document

... Breast cancer susceptibility gene 1 (BRCA1) was firstly identified as one of the genes that conferred genetic predisposition to early-onset breast and ovarian cancer ...involved in multiple ... See full document

... cells in different tissue areas have distinct characteristics [32]. In central areas of the tumor, carcinoma cells maintain an epithelial cell phenotype, but carcinoma cells in the invasive ... See full document