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[PDF] Top 20 Epigenetics and alternative splicing

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Epigenetics and alternative splicing

Epigenetics and alternative splicing

... cis- and trans-mediated regulatory effects of ...intergenic and cis-antisense RNAs are more stable than those derived from introns and with the sub-cellular localization analysis there is indication ... See full document

78

A statistical method for the detection of alternative splicing using RNA-seq.

A statistical method for the detection of alternative splicing using RNA-seq.

... P0.01) and logistic regression model (designated as LR) were divided into 3 non-overlapping categories: common, ...P0.01_uniq and LR_uniq (Figure ...P0.01_uniq and LR_uniq junctions, ...significant ... See full document

8

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.

... the splicing of flip/flop exon, we focused on the Gria2 gene to explore the potential involvement of several recent models of splicing ...assemble and hence increase the chance of the ... See full document

25

Estudo das múltiplas isoformas do gene Patched1 em ceratocisto odontogênico

Estudo das múltiplas isoformas do gene Patched1 em ceratocisto odontogênico

... Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. ... See full document

59

Intrinsic disorder in the BK channel and its interactome.

Intrinsic disorder in the BK channel and its interactome.

... skeletal and smooth muscles, exocrine cells, and sensory cells of the inner ...distribution, and potential mechanisms of intrinsic disorder in 27 BK channel variants from mouse cochlea, 104 ... See full document

15

Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases

Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases

... As in other hematophagous insects, female sand flies form a peritrophic matrix (PM) around the blood bolus after feeding. The importance of this PM was demon- strated in Phlebotomus papatasi flies fed with blood ... See full document

6

Analysis of the contribution of alternative splicing to glioma subtype definition

Analysis of the contribution of alternative splicing to glioma subtype definition

... in splicing factors, whereas among the list of genes considered to be differentially expressed these were 41, among the differentially spliced genes there were 46 splicing factors were found to be ... See full document

114

Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F.

Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F.

... (1) and the remainder is G triplets (Table ...exonic and intronic G tracts between hnRNPH/F-activated and hnRNPH/F-repressed exons are sta- tistically significant (p-value ...of alternative ... See full document

10

A Computational Platform for Assessing the Impact of Alternative Splicing in Cancer

A Computational Platform for Assessing the Impact of Alternative Splicing in Cancer

... Aberrant alternative splicing has been recognised as having a very important role in cancer development (Sette, Ladomery, and Ghigna 2013), (Venables ...cheaper and, with advancements in ... See full document

82

Epigenetics of royalty.

Epigenetics of royalty.

... patterns and splicing sites, including those that can generate alternative ...queens and workers. Both queens and workers show similar levels of expression of a common long variant of ... See full document

4

Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates.

Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates.

... closure and degeneration has not been fully elucidated, but is associated with apoptosis and cytolytic necrosis in the inner media and ...syndrome and ageing. Immunohistochemistry on human ... See full document

7

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.

... Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional ...Abnormal alternative ... See full document

13

MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs.

MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs.

... annotation, and expression profiling of alternative transcripts and for elucidating the regula- tory mechanism of ...constructed, and these resources are currently available to the public on ... See full document

9

Identification of rare alternative splicing events in MS/MS data reveals a significant fraction of alternative translation initiation sites

Identification of rare alternative splicing events in MS/MS data reveals a significant fraction of alternative translation initiation sites

... mass and fragment mass were searched with mass tolerance of 6 ...(protein), and Pyro-Glu ...acids and a maximum of two miscleavages were ...peptide and protein ...combined and reported ... See full document

15

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

... exon and exon-exon junction probe sets (see probe-set design in Figure 4B), and interrogates all of the splicing events supported by mouse EST/mRNA evidence within the UCSC/Ensembl ...an ... See full document

17

Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless.

Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless.

... so and demonstrated to regulate its transcription by Eyeless [51] ...4 and 8, and ...1 and 5, and ...added and showed to compete with themselves in the Figure ...Ey(2a) ... See full document

10

Identification of a novel function of CX-4945 as a splicing regulator.

Identification of a novel function of CX-4945 as a splicing regulator.

... proteins and their altered patterns in a manner similar to that of TG-003, we tested the effects of CX-4945 on two Figure ...on alternative splicing of numerous ...hours, and total RNA was ... See full document

8

Alternative splicing of sept9a and sept9b in zebrafish produces multiple mRNA transcripts expressed throughout development.

Alternative splicing of sept9a and sept9b in zebrafish produces multiple mRNA transcripts expressed throughout development.

... I and II are a result of sept9a transcript inhibition ...functions, and that over-expression of only sept9a_tv1 cannot compensate for the loss of multiple ...artifact and one caused by knocking-down ... See full document

7

Integrative annotation of 21,037 human genes validated by full-length cDNA clones.

Integrative annotation of 21,037 human genes validated by full-length cDNA clones.

... structure and function of the genes in the human ...structural and functional diversity at the gene ...novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, ... See full document

20

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.

... study and attributed this finding to dysfunction of the spliceosome secondary to SMN ...P11 and our P13 data set, when raw data are analysed in the same way (Figures S6, S7; Tables S1, S9, S10, ...whether ... See full document

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