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[PDF] Top 20 Foxp3+ regulatory T cells control persistence of viral CNS infection.

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Foxp3+ regulatory T cells control persistence of viral CNS infection.

Foxp3+ regulatory T cells control persistence of viral CNS infection.

... regulatory T cells (Tregs) in autoimmune and pathogen-induced immune responses has been studied intensively during recent ...discovery of the transcription factor Foxp3 (forkhead box ... See full document

8

Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus.

Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus.

... the control of the Foxp3 promoter were infected with FV, and Tregs were depleted starting at the time point of infection by five injections (days 0, 2, 4, 6, and 8 postinfection) ... See full document

3

T Cell Subset in Host Homeostasis during Protozoan Infection: An Overview

T Cell Subset in Host Homeostasis during Protozoan Infection: An Overview

... rates of morbidity and mortality ...lifelong persistence of parasites. Regulatory T cells (Treg), in particular the CD4 + CD25 + cell subset, appear to control the immune ... See full document

11

Anatomy of viral persistence.

Anatomy of viral persistence.

... understanding of negative immune regulators, including IL-10 and PD-1, are still at an early stage; nevertheless, the implications are important and ...hyporesponsive T cells found in persistent ... See full document

4

Dynamics of regulatory T-cells during pregnancy: effect of HIV infection and correlations with other immune parameters.

Dynamics of regulatory T-cells during pregnancy: effect of HIV infection and correlations with other immune parameters.

... increase of CD8+CD25+ FoxP3+% and CD4+TGFb+% over the course of ...tolerance of the fetus ...mediator of the anti- abortogenic effect of progesterone in mice ...lack of ... See full document

8

Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine.

Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine.

... mobilization of CD107a and ICS were evaluated after in vitro culture of splenocytes in the presence or absence of the antigenic ...stimulus. Cells were washed 3 times in plain RPMI and re- ... See full document

16

The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma

The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma

... preservation of self-tolerance and modulation of overall immune responses against infections and tumor ...Th17 cells protect against fungal and parasitic infections and participate in inflammatory ... See full document

5

Rev. bras. ter. intensiva  vol.24 número3 en v24n3a14

Rev. bras. ter. intensiva vol.24 número3 en v24n3a14

... number of Treg cells may contribute to autoimmunity because adoptive transfer of these cells results in positive ...production of Treg cells may be stimulated at peripheral sites ... See full document

8

Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

... release of soluble factors, which are associated with many regulatory efects of these cells in a tissue inlammation ...basis of their properties, MSCs have been explored in a wide range ... See full document

12

HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?

HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?

... contribution of mDCs to HIV spread might be also supported by the levels of circulating lipopolysaccharide (LPS), which are significantly augmented in chronically HIV-infected individuals, due to the ... See full document

9

CD4+FoxP3+ regulatory T cells from Gαi2-/- mice are functionally active in vitro, but do not prevent colitis.

CD4+FoxP3+ regulatory T cells from Gαi2-/- mice are functionally active in vitro, but do not prevent colitis.

... and cells were then washed in phosphate-buffered saline (PBS) containing 1% heat inactivated fetal calf serum ...isolation of colonic lamina propria lymphocytes (LPL), dissected colons were washed free ... See full document

10

Quantification of Treg cells in peripheral blood and lymph nodes of dogs with multicentric lymphoma

Quantification of Treg cells in peripheral blood and lymph nodes of dogs with multicentric lymphoma

... When comparing Tregs expression in peripheral blood between dogs with lymphoma and healthy dogs (LG x CG), results showed that LG subjects expressed significantly higher numbers of Tregs compared to healthy dogs. ... See full document

7

On modeling HIV and T cells in vivo: assessing causal estimators in vaccine trials.

On modeling HIV and T cells in vivo: assessing causal estimators in vaccine trials.

... aspects of the prevention problem render the whole-body, deterministic model inap- ...site of the initial struggle may be ...probability of cells coming ...CD8 T cells (1% ... See full document

10

In vivo SPECT reporter gene imaging of regulatory T cells.

In vivo SPECT reporter gene imaging of regulatory T cells.

... some of the mechanisms of action of Tregs [26] these include: 1) the importance of Treg-DC interaction for Treg function [27], 2) the relevance of sequential migration of Tregs ... See full document

8

Role of regulatory T cells in irinotecan-induced intestinal mucositis

Role of regulatory T cells in irinotecan-induced intestinal mucositis

... reproducibility of ex- perimental model of intestinal mucositis induced by ...most of previous data on the pathophysiology of mucositis was obtained with this mouse strain (Lima-Júnior et ... See full document

9

Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy.

Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy.

... expansion of Treg, higher proliferation rates were achieved with beads as compared to platebound anti-CD3+ soluble anti-CD28 mAb (Figure ...expansion of Treg with either stimulation mode, using optimal ... See full document

13

Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals.

Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals.

... CD4+ T cells were positively selected from frozen PBMCs (median time [IQR] of cryopreservation was 616 [333–1448] days) using magnetically labeled CD4 microbeads and subsequent column purification ... See full document

11

CCR7 expression and intratumoral FOXP3+ regulatory T cells are correlated with overall survival and lymph node metastasis in gastric cancer.

CCR7 expression and intratumoral FOXP3+ regulatory T cells are correlated with overall survival and lymph node metastasis in gastric cancer.

... surface of naive T cells and dendritic cells (DCs), SLC (secondary lymphoid chemokine, CCL21) and ELC (EB11-ligand chemokine, CCL19) are its two high-affinity ...migration of T ... See full document

7

Defensins and viral infection: dispelling common misconceptions.

Defensins and viral infection: dispelling common misconceptions.

... forms of a-defensins are highly attenuated for binding to and/or inactivation of viral ...line of investigation using direct mutational analysis showed that arginine to lysine substitutions at ... See full document

3

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells.

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells.

... assays, cells were incubated on ice with Fc block containing 20% normal mouse serum (Sigma) for 20 min prior to ...noted. Cells were stained with anti-CD8 PE-Cy5 (Clone ...Fixed cells were then ... See full document

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