[PDF] Top 20 Functional analysis of genetic variants associated with risk for breast cancer: 12q24, a candidate risk locus

Functional analysis of genetic variants associated with risk for breast cancer: 12q24, a candidate risk locus

... modification of DNA and histones is also involved in gene expression ...(K) of histones H3 and H4 (Hellman & Chess 2010; Ellis et ...expression of the DNA information is partially regulated by ... See full document

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Functional Characterization of Variants of Unknown Significance in Familial Breast Cancer

... insults of diverse ...repair of these breaks is critical for cellular integrity (Ahmed et ...loss of cell integrity, and possibly tumourigenesis (Krejci et ...highly associated with BC ... See full document

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Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk

... 3′-UTR of the transcript ENST00000369291.5 of the RNF115 gene, for which the reference allele was predicted to ...2 Breast cancer risk loci with strong predictions for ... See full document

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Genetic variants at 1p11.2 and breast cancer risk: a two-stage study in Chinese women.

... and breast cancer susceptibility identified the marker SNP of ...site of NOTCH2, a gene associated with insulin release, insulin sensitivity, obesity and type 2 diabetes ... See full document

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The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.

... plausible candidate low penetrance genetic risk factor, and its association with breast cancer risk has been investigated by several ...been associated with ... See full document

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Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

... number of minor alleles of each putative functional SNP carried by an ...the genetic variable in logistic regression models of case-control status after adjusting for age, reported ... See full document

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Genetic variants in MUC4 gene are associated with lung cancer risk in a Chinese population.

... strengths of this study. First, to the best of our knowledge, no study has evaluated MUC4 SNPs for associations with lung ...lung cancer is a multifactorial disease that likely involves ... See full document

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Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review.

... studied cancer risks markers at defined risk loci are often poorly linked to the actual risk ...this genetic diversity among populations may therefore allow better mapping of these true ... See full document

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Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.

... ,35% of all colorectal cancer (CRC) cases ...application of genome-wide association studies (GWASs) have identified a number of common variants involved in the etiology of ...a ... See full document

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Genetic variants associated with ectopic calcifications

... homeostasis of cartilage and bone ...281]. Variants in this gene result in hand osteoarthritis [277, 282] and other skeletal diseases, including multiple epiphyseal dysplasia, which is characterized by ... See full document

271

Mediterranean dietary pattern and risk of breast cancer.

... diet of WLH study participants is different from that of participants in studies conducted in Mediterranean ...consumption of vegetables and fruits in this cohort was lower than in the Greek EPIC ... See full document

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Joint effects of febrile acute infection and an interferon-γ polymorphism on breast cancer risk.

... cascade of host defense mechanisms by inducing the proliferation and differentiation of leucocytes and the secretion of interferons (IFNs), tumor necrosis factor (TNF)-a, antibodies, and neutrophil ... See full document

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Table 3 - Meta-analysis on the relative risk (RR) of cancer in

... effects of high doses (99,110,111). More than 40 phase I/II clinical cancer trials ...combination with chemotherapeutics are under- way ...effects of metformin. This drug is used jointly ... See full document

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Re: Lack of association between Matrix Metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma

... increased risk of RCC in ...result of the afore- mentioned study, the geneticists will have to plan a wider population based study to answer to the ques- tion about the MMP1 promoter polymorphism and ... See full document

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HIV tropism and decreased risk of breast cancer.

... tation of envelope (env) genes from HIV ...co-transfected with an env-deleted ‘‘HIV genomic vector’’ (B) containing a firefly luciferase reporter gene that is used to quantify viral ...Co-transfection ... See full document

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Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk.

... in breast cancer tumorigenesis remains largely ...3438 breast cancer cases, and 228 normal ...ductal breast cancers compared to normal breast tissues and a significant elevation ... See full document

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The association between breast tissue optical content and mammographic density in pre- and post-menopausal women.

... (MD), associated with higher water and lower fat content in the breast, is strongly related to breast cancer ...method of evaluating breast tissue composition by red and ... See full document

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Rev. Hosp. Clin. vol.58 número2

... most of the time that they were taking a hormonal ...use of any hormonal manipulation, and that may have been the reason for increased refusal among them ...risks of relapse by using ...potential ... See full document

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Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer

... increased risk of breast cancer associated to the TC/CC genotypes with OR of ...meta-analysis of the hsa-miR- 196a2 distribution that suggested that women ... See full document

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Biostatistical analysis of treatment results of bacterial liver abscesses using minimally invasive techniques and open surgery

... Biostatistical analysis of treatment results of bacterial liver abscesses using minimally invasive techniques and open ...one of the most difficult complications in surgical hepatology, both ... See full document

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