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[PDF] Top 20 FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia.

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FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia.

FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia.

... Deficiency of FXN transcriptional initiation in the YG8sR mouse The combination of repressive epigenetic changes and transcriptional deficiency extending upstream ... See full document

12

Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia.

Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia.

... Friedreich ataxia (FRDA) is an autosomal recessive disorder characterized by neurodegeneration and ...cardiomyopathy. The presence of a GAA trinucleotide repeat expansion in the ... See full document

13

MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.

MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.

... expansion in an allele-dose dependent manner. In the current study, the effect of Mlh1 on intergenerational transmission of the YG22 FXN GAA mouse ... See full document

10

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.

... microarrays. The NIA 15K mouse cDNA library [14,50] was purchased through the UK Medical Research Council and printed in duplicate onto glass slides by the Genomics and Proteomics ... See full document

12

Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing.

Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing.

... telomere. In order to study hysteresis, we grow two different populations of yeast from the same strain, as illustrated in ...grown in absence of any splitomycin and the ... See full document

20

Dement. neuropsychol.  vol.8 número1

Dement. neuropsychol. vol.8 número1

... ABSTRACT. The Action Fluency (AF) and Action Naming (AN) are different tasks involving verb ...analyze the information available in the scientific literature on the mechanism and ... See full document

11

LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid β-oxidation of lipid droplets.

LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid β-oxidation of lipid droplets.

... Germany). The specificities of the LSDP5 antibodies were confirmed by Western blot analysis (Figure ...USA). Mouse mono- clonal His antibody (catalog ...Effect of LSDP5 constructs on ... See full document

14

The Concept of Early Vascular Ageing – An Update in 2015

The Concept of Early Vascular Ageing – An Update in 2015

... measurement of pulse wave velocity along the aorta, the largest elastic artery, as a marker of arterial ...stifness. In recent years the new concept of early vascular ... See full document

7

Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model.

Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model.

... analyzed the impact of infection on vasculature ...infection the morphology of the tissue was generally well preserved although signs of mild vascular throm- bosis and ... See full document

11

Electronic Government In Democratic Public Service In One Door Integrated Permit Handling Services Agency In The City Of Samarinda

Electronic Government In Democratic Public Service In One Door Integrated Permit Handling Services Agency In The City Of Samarinda

... Development of information technologies and communication in a public sector have to pay more attention to the complexity in its implementation rather than focusing on best practice and ... See full document

6

Factors Affecting The Adoption Of Mhealth In Maternal Health Care In Nakuru Provincial General Hospital

Factors Affecting The Adoption Of Mhealth In Maternal Health Care In Nakuru Provincial General Hospital

... use of mobile telephony technology to address healthcare challenges such as access, quality, affordability, matching of resources, and behavioral norms ...partner in health care’s shift towards a ... See full document

14

The role of business intelligence in decision process modeling

The role of business intelligence in decision process modeling

... still in the development phase and they represent interest- ing areas for ...management in the context of marketing, there are critical research chal- lenges that should be devoted ... See full document

9

Insights into the physiological function of cellular prion protein

Insights into the physiological function of cellular prion protein

... ability of PrPc to bind copper may modulate the activity of the major cellular antioxidant enzyme Cu/Zn superoxide dis- mutase (SOD-1) and consequently cellular resistance to oxidative ... See full document

11

The quality of castings obtained during lost-wax and Replicast CS processes in aspect of ecology

The quality of castings obtained during lost-wax and Replicast CS processes in aspect of ecology

... Haratym, Dok ł adno ć wymiarowa odlewów wykona- nych w procesie Replicast CS, Archiwum Odlewnictwa rocznik 3, nr 9, Katowice 2003.. Arendarski, Niepewno ć pomiarów, Oficyna Wydaw- nic[r] ... See full document

5

Molecular biology of the kallikrein-kinin system: from structure to function

Molecular biology of the kallikrein-kinin system: from structure to function

... alteration in the B2 receptor gene. In order to obtain more information on the physiological function of bradykinin, Wang et ...a mouse model harboring the human ... See full document

7

Selection of the temperature of casting the bronzes to plaster moulds

Selection of the temperature of casting the bronzes to plaster moulds

... from the temperature of casting the bronze to the mould on Figure ...From the introduced cross - section of casts from the probe TDAg, it results that it together with ... See full document

6

In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice.

In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice.

... Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during infection has proven difficult due to the low spirochete loads in ... See full document

18

The Impact of E-Commerce Securi ty, and National Environment  on Consumer adoption of Intern et Banking in Malaysia and  Singapore

The Impact of E-Commerce Securi ty, and National Environment on Consumer adoption of Intern et Banking in Malaysia and Singapore

... as the extent to which a person views an innovation as offering an advantage over previous ways of performing the same task (Roger, 1983; Agarwal & Prasad, ...adopters of Internet banking ... See full document

20

DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor.

DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor.

... In the present study, we explored for the first time the pattern of methylation in the promoter of the murine Oxtr gene and its association with ... See full document

11

Linking Core Promoter Classes to Circadian Transcription.

Linking Core Promoter Classes to Circadian Transcription.

... cover promoter DNA. In this ground state, the TSS is assumed to be covered by a nucleosome which constitutes a certain barrier for Pol II to penetrate ...loosening the nucleosomal ...for ... See full document

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