[PDF] Top 20 Genetic biomarkers for ALS disease in transgenic SOD1(G93A) mice.
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Genetic biomarkers for ALS disease in transgenic SOD1(G93A) mice.
... during disease progression could be induced by the neurodegenerative progress of the ...denervation in mouse skeletal muscle ...A in ALS skeletal muscle promotes denervation in ... See full document
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Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS.
... role in the maintenance of axonal calibre ...mainly in the length of the C- terminal tail domain, which results in different states of phosphorylation and susceptibility to proteases ...Mutations ... See full document
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Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
... the SOD1 G93A mouse model of ALS on a defined background is highly predictable and shows low variability in a number of readouts, particularly ...survival. In addition there are early and ... See full document
12
Potencial terapêutico das células mononucleares da medula óssea em um modelo experimental de esclerose lateral amiotrófica
... neurodegenerative disease characterized by the selective loss of both lower and upper motoneurons in the spinal cord, brain stem and motor ...death in 2 to 5 ...potential in transgenic ... See full document
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A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model.
... the in vivo efficacy of WN1316, we initiated a post onset-intragastric administration of WN1316 in ALS ...only ALS(- SOD1 H46R ) mice but also ALS(SOD1 G93A ) ... See full document
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A1 and A2A Adenosine receptors expression in ALS transgenic mice for the human gene SOD1
... to ALS, the exact pathogenic mechanisms are still largely ...of ALS is largely based on studies of ALS-associated gene ...familial ALS are similar, it can be predicted that insights from ... See full document
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Comparative Magnetic Resonance Imaging and Histopathological Correlates in Two SOD1 Transgenic Mouse Models of Amyotrophic Lateral Sclerosis.
... fatal disease due to motoneuron ...the disease course but a direct correlation with neuropathology is not feasible in ...Therefore in this study we aimed to examine MRI changes in ... See full document
19
Detection of prion infectivity in fat tissues of scrapie-infected mice.
... tg44 mice and WT ...detected in uninoculated tg44 or WT mice. For tg44 mice (A), lane 1, mock infected tg44 mouse brain, ...tested. In tg44 mice, spinal cord, spleen, lymph node, ... See full document
6
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.
... proteins in conformational diseases. In addition to influencing the misfolding and aggregation behavior of the mutant proteins, polymorphisms in putative modifier genes may affect the molecular ... See full document
9
Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites.
... detected in conjunctival-limbal region of all four groups ...occurred in the central corneal epithelium of the experimental Le-Cre Tg/2 ; Pax6 fl/+ mice ...cells in the central corneal ... See full document
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β1-syntrophin modulation by miR-222 in mdx mice.
... GAPDH in the same RNA sample. The mRNA levels in the mdx samples are expressed as fold change compared to those in the wt ...mdx mice (see ...mdx mice were resolved by SDS-PAGE and ... See full document
12
Inflammation Induces TDP-43 Mislocalization and Aggregation.
... protein in LPS-activated astrocytes and ...from transgenic (hTDP-43 A315T ) and non-transgenic litters were treated for 1 day with LPS at 1 μg/ml or ...difference in protein ...between ... See full document
19
Mitochondrial genetic therapy in Parkinson’s disease
... In order to perform the cell growth and plasmid production studies, bank cells with E.coli JM109, DH5α and XL1B transformed with the pCAG-GFP-mtND1 were prepared. Fermentations were carried out as previously ... See full document
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Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice.
... beneficial in PD and DLB by directly modulating aggregation of α-synuclein ...found in Lewy Bodies (LBs), the pathological hall- mark of PD and DLB, and is genetically and molecularly linked to ... See full document
20
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice.
... neurogenesis in hippocampal cognition has also been difficult to ...[12–15,29–32] in varied strains of mice [32–35] and to assess cognitive behavior on multiple ‘‘standard’’ testing instruments [36] ... See full document
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Utrophin up-regulation by an artificial transcription factor in transgenic mice.
... [17–18,41–42]. In particular, we engineered ZF ATFs with the aim of up-regulating the utrophin gene, a possible substitute for dystrophin in DMD ...consists in the extremely large size of its mRNAs, ... See full document
8
Increased abscess formation and defective chemokine regulation in CREB transgenic mice.
... [1,2,3]. In hematopoietic cells, CREB regulates normal and leukemic cell proliferation and ...role in immune function by interacting with NFkB activation, inducing macrophage survival, and regulating ... See full document
9
Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
... using SOD1 (G93A) mice demonstrated that, compared to WT mice, mutant mice run significantly greater daily distances on a running wheel [31], in line with a documented increased ... See full document
13
Therapeutic Effects of α1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice.
... SPLUNC1. In the current study, we found that A1AT increased SPLUNC1 in BAL fluid of wild-type mice, but did not affect SPLUNC1 levels in ENaC Tg ...SPLUNC1 in PA-infected ENaC Tg ... See full document
12
Alterações de deglutição e fonação na Esclerose Lateral Amiotrófica
... result in dead or permanent ventilatory ...available in the literature. Method. In this study of literature review, it was achieve a search in the main basis LILACS and SciELO, with the ... See full document
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