[PDF] Top 20 Whole-genome analysis of DNA methylation across cancer types reveals specific patterns in early stages
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Whole-genome analysis of DNA methylation across cancer types reveals specific patterns in early stages
... widespread methylation sequence recognition motif is “5'-CpG- ...human genome. Moreover, there are defective and highly enriched segments of these dinucleotides, called CpG islands (Laird ...50% ... See full document
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Analysis of Matched Tumor and Normal Profiles Reveals Common Transcriptional and Epigenetic Signals Shared across Cancer Types.
... studies of transcriptional changes have focused mainly on tumor samples, without consideration of normal ...tissue. In contrast, studies of mutations, structural variations or DNA copy ... See full document
14
The identification of specific methylation patterns across different cancers.
... Abnormal DNA methylation is known as playing an important role in the ...specificity of diagnosis and therapeutic targets for cancers based on characteristics of DNA ... See full document
16
Morphological changes of Paulownia seedlings infected phytoplasmas reveal the genes associated with witches' broom through AFLP and MSAP.
... DNA methylation is a widespread epigenetic modification, mainly occurs at gene promoter, or transcribed regions [11–13], playing an important role in regulation of gene expression mediating ... See full document
9
Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.
... Contamination of normal cells is almost always present in tumor samples and affects their molecular ...analyses. DNA methylation, a stable epigenetic modification, is cell type-dependent, and ... See full document
10
Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.
... V600E in colorectal cancer. We first tested whether expression of BRAF V600E causes DNA hyper- methylation by stably expressing BRAF V600E in the CIMP- negative, BRAF wild-type ... See full document
11
The prima donna of epigenetics: the regulation of gene expression by DNA methylation
... involved in imprinting ...by DNA methyla- tion in addition to other factors of a parent specific ...setting of imprinting takes place by a methylation wave occurring soon ... See full document
11
Epigenetic of colorectal cancer: a focus on microRNAs
... 83 stages of disease. Although little is known regarding genome-wide miRNA methylation in CRC, involvement of DNA methylation in miRNA expression alterations ... See full document
132
Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality.
... site of the H19 ICR targeting vector [45]. The direction of the insert was verified by NheI ...done in ES cells as before ...None of the male chimeras produced viable mutant ...dpc in ... See full document
11
Morphologi cal analysis and DNA methylation in
... phenotypes of C. bonariensis showed differences in several morphological ...(2008), in Fallopia japonica (Houtt.) Ronse Decr. with the weed/ruderal of Polygonaceae family, and by Marfil et ... See full document
12
Genome-wide methylation patterns in Salmonella enterica Subsp. enterica Serovars.
... and Analysis was also carried out using SMRT Analysis ...position in the genome, the observed IPD was compared to the IPD of an in-silico control using a two- sample t-test, and ... See full document
13
Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.
... challenge in our work and to this field in general, is the difficulty in demonstrating and quantifying the influence of DNA methylation on gene ...lack of methods for ... See full document
24
Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers
... S1. Genome-wide impact of DNA methylation on gene ...Distribution of Spearman correlation coefficients (SCC) between DNA methylation and cognate gene expression levels ... See full document
12
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
... power of using gene expression data from specific cells or physiological and genetic manip- ulations to build an interpretive framework for the complex gene expression profiles of clinical samples (Lamb et ... See full document
9
Initiation of genome instability and preneoplastic processes through loss of Fhit expression.
... distinctions in the Fhit-loss model that make it a more likely mechanism for the origin of genome ...because of the inherent fragility at the FRA3B locus, the FHIT gene has been called the ... See full document
16
Polymorphisms in the interleukin 18 receptor 1 gene and tuberculosis susceptibility among Chinese.
... Comparisons of sex and age between TB patients and controls were performed using the x 2 ...Differences of mean age between cases and controls were analyzed by use of an unpaired t ...analyses ... See full document
8
Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.
... The methylation of PCGTs, which is triggered by age and by environmental factors that are associated with cancer development, reduces cellular differentiation and leads to the accumulation of ... See full document
15
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
... Kits in fro- zen whole blood PAXgene ...batches of ninety-six samples each) during processing for unidentified reasons and the samples were not ...nanograms of RNA was used for the kit. The ... See full document
24
Regulon-specific control of transcription elongation across the yeast genome.
... signal of RPCC over GRO in glucose for RP genes suggests that an accumulation of non-transcribing RNA polymerases takes ...accumulation of inactive RNA pol II on ribosome-related genes is ... See full document
13
A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes.
... reported whole genome bisulfite se- quencing data from white people [including a male centenarian (Y103) and a male middle- aged subject (Y26) [19]] were included for ...most of the DMRs were ... See full document
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