[PDF] Top 20 HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44
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HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44
... Formalin-fixed paraffin-embedded (FFPE) blocks from multiple patients were visualized using TMA method to reduce the amount of reagents required for immunostaining of an entire array. Briefly, all FFPE tissue blocks were ... See full document
9
Differential peripheral blood gene expression profile based on Her2 expression on primary tumors of breast cancer patients.
... Breast cancer prognosis and treatment is highly dependent on the molecular features of the primary ...These tumors release specific molecules into the environment that trigger characteristic ... See full document
8
CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.
... be associated with TTP tumor suppressor functions in human cancer, we analyzed The Cancer Genome Atlas (TCGA) breast cancer, lung adenocarcinoma, lung squamous cell ... See full document
24
A common variant in the SIAH2 locus is associated with estrogen receptor-positive breast cancer in the Chinese Han population.
... survival, cell proliferation, and an enhanced metastatic phenotype, all of which are advantageous for neoplastic cells ...mammary tumors [27]. Moreover, SIAH2 is closely related with ... See full document
5
The efficacy of lapatinib in metastatic breast cancer with HER2 non-amplified primary tumors and EGFR positive circulating tumor cells: a proof-of-concept study.
... issues with EGFR testing in breast cancer tumor specimens: in 810 patients less than 10% had breast cancers that stained positively ...study. Cancer is characterized by extensive ... See full document
7
Most random gene expression signatures are significantly associated with breast cancer outcome.
... published breast cancer signatures, but has no bearing on their usefulness in the clinic: a marker may be accurate without yielding interesting biological insight regarding the mechanism of disease ... See full document
8
The prognostic significance of cancer-associated fibroblasts in esophageal squamous cell carcinoma.
... was associated with larger size, advanced T stage, lymph node metastasis, and poor ...and cancer types, this result is highly consistent with previous studies in which patients with ... See full document
9
Transcription factor Oct1 is a somatic and cancer stem cell determinant.
... activities associated with stem cells, but do not address whether Oct1 controls the stem cell phenotype ...pre-treated with doxycycline for 48 hr and injected into ... See full document
14
Development of RNA aptamers as molecular probes for HER2+ breast cancer study using cell-SELEX
... round, cell suspension was prepared by short incubation, about min, of cell culture with ...cells with high affinity, we gradually increased the stringency of selection conditions during the ... See full document
11
CITED2 and the modulation of the hypoxic response in cancer
... interaction with VHL and proteasomal ...associates with the HIFβ subunit to form HIF-1 and to bind to specific hypoxia- response elements in hypoxia-regulated genes (Figure ... See full document
19
PD-L1 expression is increased in a subset of basal type breast cancer cells.
... distributions with Graphpad Prism 6 software. HER2 was not evaluated due to insufficient number of positive cases on the microarray for meaningful ... See full document
10
Factors associated with oxidative stress in women with breast cancer
... Objective: To assess the association between physiolog- ical, physical, lifestyle and nutritional variables and oxidative stress biomarkers in women with breast cancer. Methods: This cross-sectional ... See full document
9
The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer.
... compared with differenti- ated cancer cells, TICs are more resistant to conventional cancer ...the CD44 high CD24 low subpopulation, a surrogate for human breast cancer ... See full document
12
For or against adjuvant trastuzumab for pT1a-bN0M0 breast cancer patients with HER2-positive tumors: a meta-analysis of published literatures.
... Yin), with the last search on 10 September, ...Antonio Breast Cancer Symposium (years 2006–2011), and the CD proceedings of the International ...Gallen Breast Cancer Conference (years ... See full document
7
Rev. Assoc. Med. Bras. vol.49 número4
... of breast cancer in postmenopausal ...in Breast Cancer. Breast cancer and hormone replacement therapy: colaborative reanalysis of data from 51 epidemiological studies of 52705 ... See full document
1
The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.
... and cell cycle arrest than p53 72Arg ...differences are likely due to differential transcriptional activities of the two codon 72 ...genes with a key role in DNA repair more efficiently than p53 ... See full document
10
An Unusual Case of Invasive Encapsulated Papillary Carcinoma of the Breast: A Case Report
... and HER2, with a Ki-67 proliferative index of 100% and positive for CK 5/6 ...sion with the attending pathologist, carcinoma with cystic degeneration or IPC simultaneously associated ... See full document
5
Rev. Bras. Hematol. Hemoter. vol.38 número2
... proceeded with high-dose melphalan and rescue with autologous hematopoietic progen- itor stem cell transplantation and subsequent radiotherapy against the sternal ... See full document
4
Association of PKCζ expression with clinicopathological characteristics of breast cancer.
... to cancer. It has been suggested that atypical PKCs contribute to cell proliferation and cancer ...progression. With respect to breast cancer, PKCf has been found to play a key ... See full document
6
Sao Paulo Med. J. vol.123 número4
... Thirty-one breast cancer patients with positive family history (criteria from the Breast Cancer Linkage Consortium) were studied, and genomic DNA was extracted from peripheral ... See full document
6
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