[PDF] Top 20 Hypoxia activated EGFR signaling induces epithelial to mesenchymal transition (EMT).

... polarized epithelial cells to mesenchymal cells, Epithelial–Mesenchymal Transition ...metastasis. Hypoxia is known to induce EMT; however the molecular mechanism is ... See full document

... Smad/TGFβ signaling and enhanced CTGF expression, along with enhanced levels of SNAI1 mRNA in SSc are suggestive of EMT induction, our results do not confirm full transition in the SSc epidermis in ... See full document

... NF-kB signaling promoted EMT in the absence of TGF-beta, whereas inhibition of NF-kB signaling prevented and reversed EMT ...STAT3/Snail signaling pathway, and IL6 overexpression dis- played ... See full document

... when activated keratinocytes acquire migratory capacity (mes- enchymal phenotype) [35] and (2) supplying dermis with activated fibroblasts and myofibro- blasts from the pool of epithelial cells ... See full document

... tied to tumorigenesis, as they regulate cell metabolism and angiogenesis through their control of hypoxia-inducible factor (HIF) ...aimed to investigate this role by closely examining the ... See full document

... exist to the eventual translation of 20(S)-Rg3 to clinical ...with to induce the various biological effects seen in this ...upstream signaling events leading to the inhibition of ... See full document

... the mesenchymal markers vimentin and a-SMA, and of activated TGF-b signaling evidenced by nuclear translocation of the EMT-associated transcription factors Snail1 and phospho-Smad3 in treated ...mild ... See full document

... able to induce ...similar to the data presented ...ability to promote a durable tumor regression or promote tumor progression ...shown to support tumor growth ...here induces polyclonal ... See full document

... terconverting epithelial cells into cells with mesenchymal / stem cell (SC) state ...program, mesenchymal-epithelial transition (MET), were activated in tumour cells and this ... See full document

... contrast to an earlier study that reported activation of RhoA by Cyt D treatment in Swiss 3T3 fibroblasts [31] we observed reduced RhoA activity in non-metastatic MCF-7 cells after Cyt D treatment that was ... See full document

... drugs induces cancer and endothelial cell death ...suggested to induce and be associated with focal adhesion kinase (FAK) expression via activation of NFkB signaling ...14-3-3e induces HCC ... See full document

... TGF-b signaling and upregulated Smad7 expression ...b signaling [39], however, TBP-2 deficiency enhanced TGF-b- mediated Smad2 phosphorylation ...TGF-b signaling, Smad7 requires to bind ... See full document

... kinases activated by neurotrophins and other growth ...TrkB induces the activation of various downstream signaling pathways including Akt, Src, or MAPK resulting in cell proliferation, and apoptosis ... See full document

... histone modification H3K9ac (Figure S2), which led us to further examine the impact of sorafenib on the expression of histone- modifying enzymes. H3K9ac is specifically mediated by GCN5 and PCAF, which are two ... See full document

... the epithelial–mesenchymal transition (EMT), a pro- gramme by which epithelial cells acquire motility, invasiveness and resistance to ... See full document

... response to the environment through which they migrate, independently of the neural tube from which they are ...mass to the paired lateral nasal and maxillary ... See full document

... inhibited epithelial-to-mesenchymal transition (EMT), which is characterized by increased E-cadherin expression and decreased vimentin, N-cadherin and Slug ... See full document

... due to their immunosuppressive and pro-angiogenic ...marrow to imitate the tumor inflammatory microenvironment, and then co-cultured with different HCC ...TNFa. To explore the potential mechanisms ... See full document

... assumption, to provide further evidence supporting the inhibitory role of Esrp1 on mRNA translation, we performed polysomal profiling ...subjected to sucrose gradient fractionation and total RNA was ... See full document

... PRM, which is extracted from eight kinds of traditional Chinese medicines, has very good lung protection in clinical use. In our previous toxicological study, Sprague-Dawley rats were administered with 10 and 30 g/kg PRM ... See full document