[PDF] Top 20 Identifying hubs in protein interaction networks.
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Identifying hubs in protein interaction networks.
... large networks of protein-protein interactions has contributed to the identification of biochemical and signaling pathways, and to functional annotation of ...Such networks have been ... See full document
10
Identification of unstable network modules reveals disease modules associated with the progression of Alzheimer's disease.
... tau protein are known as pathological hallmarks of AD, but the underlying mechanisms have not yet been ...regulated in the later stages of AD. This suggested that the molecular networks and their ... See full document
16
Identifying controlling nodes in neuronal networks in different scales.
... detected hubs in neuronal networks using degree, betweenness centrality, motif and synchronization and revealed the importance of hubs in their structural and functional ...roles. ... See full document
13
Neighbor overlap is enriched in the yeast interaction network: analysis and implications.
... property in the randomized network as the expected ...done. In general, the randomization should be done in a way that will preserve as many of the other properties of the network, such that it will ... See full document
9
Predicting Pharmacodynamic Drug-Drug Interactions through Signaling Propagation Interference on Protein-Protein Interaction Networks.
... network. In addition, the target-centered system in Huang et ...systems. In this study, we propose that both close and distant interferences of signaling propagation through the PPI network are ... See full document
13
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
... The Limma eBayes analysis (Smyth, 2004) was used to assess the differential expression status of each gene. Background intensities were adjusted and the original ex- pression datasets from all conditions were processed ... See full document
202
Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria
... early in 2005 (Shastri and Morgan, 2005) and only included the evaluation of central metabolic pathways, under different light and media conditions ...heterotrophic). In this study, cyclic and non-cyclic ... See full document
18
Fault tolerance in protein interaction networks: stable bipartite subgraphs and redundant pathways.
... growth in rich media under laboratory conditions [2,3]; for example, a gene which produces an enzyme used to metabolize one particular nutrient if other nutrients are available ...[4]. In other cases, ... See full document
11
Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners.
... filter interaction datasets for false positives ...singlish hubs and their interaction partners have complicated patterns of non ...just in time assembly of protein complexes. In ... See full document
9
Context-specific protein network miner--an online system for exploring context-specific protein interaction networks from the literature.
... about protein-interaction (PI) networks (PINs) is crucial for understanding many cellular biological processes ...Such networks are particularly useful in elucidating cellular ... See full document
13
Sequence motifs in MADS transcription factors responsible for specificity and diversification of protein-protein interaction.
... which in turn determine biological functions of ...how protein sequences define interaction specificity is largely missing, in particular for paralogous protein families with high ... See full document
13
DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
... their interaction with other genes with respect to the regulation of growth and development is major task post genome ...completed in late 2000, the functions of a large number of genes are still unknown ... See full document
11
Gene expression pro filing analysis of lung adenocarcinoma
... and protein-protein interaction (PPI) networks obtained from the STRING database were constructed with ...PPI networks was performed through MCODE in Cytoscape. In total, ... See full document
11
Unraveling spurious properties of interaction networks with tailored random networks.
... an interaction between different ...achieved in different ways. Weighted interaction networks can be derived by consid- ering estimated values of signal interdependence (sometimes mapped via ... See full document
13
Predicting protein phenotypes based on protein-protein interaction network.
... Identifying phenotypes of proteins is a central challenge of the modern genetics in post-genome era. The study on phenotypes always involves many major diseases, such as HIV [1,2,3,4,5], different kinds of ... See full document
8
Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.
... seen in the autoinhibited form of EGFR-WT and may reduce the energetic cost of inducing the active ...aC-helix. In contrast, inactivating kinase mutations often target catalytically important residues ... See full document
46
iGPCR-drug: a web server for predicting interaction between GPCRs and drugs in cellular networking.
... popular in the pattern recognition community owing to its good performance and ease of ...effective in dealing with complicated biological systems, such as identifying nuclear receptor subfamilies ... See full document
10
Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy
... DN in experimental studies (Toyoda et ...role in DN remains to be confirmed in future ...player in DN. Previous studies have demonstrated the role of this pathway in some profibrotic ... See full document
11
Network compression as a quality measure for protein interaction networks.
... complex networks?. In the absence of at least one complete and accurate interactome map it is difficult to estimate the range of true relative compression ...rates. In particular, an important ... See full document
22
Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease.
... identified in N 2ttt A , N SAM A and N 2ttt B ...given in POINeT for that network, the results exactly ...the in house algorithm was necessary to find the cliques (three and more) in the ... See full document
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