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[PDF] Top 20 Induced Pluripotent Stem Cells: Challenges and Opportunities

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Induced Pluripotent Stem Cells: Challenges and Opportunities

Induced Pluripotent Stem Cells: Challenges and Opportunities

... limited and can rarely regenerate a specific organ or tissue ...efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable ...embryonic stem ... See full document

1

Fibroblast growth factor-10 promotes cardiomyocyte differentiation from embryonic and induced pluripotent stem cells.

Fibroblast growth factor-10 promotes cardiomyocyte differentiation from embryonic and induced pluripotent stem cells.

... stimulatory and inhibitory to cardiomy- ocyte differentiation depending on the application time during the differentiation process ...2A, and 2B), which coincided with the expression pattern of the FGF-10 ... See full document

12

Reprogramming primordial germ cells into pluripotent stem cells.

Reprogramming primordial germ cells into pluripotent stem cells.

... germ cells (PGCs) are the embryonic precursors of the germ cell lineage, which are restricted to form only sperm and eggs following their specification from pluripotent epiblast ...in ... See full document

8

Induced pluripotent stem cell modeling of Gaucher's disease: what have we learned?

Induced pluripotent stem cell modeling of Gaucher's disease: what have we learned?

... limit and therefore provide an inexhaustible source of cells for ...original cells reprogrammed; this precludes the need for complex procedures to create the genetic defect and avoids ... See full document

18

Negligible immunogenicity of induced pluripotent stem cells derived from human skin fibroblasts.

Negligible immunogenicity of induced pluripotent stem cells derived from human skin fibroblasts.

... iPSCs and their derivatives should be immunologically tolerated by the ...embryonic and induced pluripotent stem cells ...immunogenic cells could be retained after cell ... See full document

15

Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells.

Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells.

... human induced pluripo- tent stem ...‘hit and run’ vector and subsequently infected with Adeno-Cre to remove the ...(H1), and reprogramming factor-free hiPSC lines(hiPSC-19 and ... See full document

10

Disease correction and generation of isogenic induced pluripotent stem cell lines for diasease modelling in patients with DAND5 mutations

Disease correction and generation of isogenic induced pluripotent stem cell lines for diasease modelling in patients with DAND5 mutations

... (LIM1), and HESX Homeobox 1 (HESX1) and the secreted factor ...activated and initiates and maintains the integrity of the node and ...dorsal and ventral mesoderm, head and ... See full document

106

Bioprocess engineering of induced pluripotent stem cells for application in cell therapy and pre-clinical research

Bioprocess engineering of induced pluripotent stem cells for application in cell therapy and pre-clinical research

... monolayers) and 44% (cardiospheres) on metabolic activity recovery was observed when ROCK inhibitor pretreatment was performed using this medium ...adhesion and cell aggregation by modulating gap junctions, ... See full document

100

Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats.

Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats.

... REFs and rat neural precursors as starting cell types and relied on serum-containing medium, non- excisable moloney murine leukemia virus (MMLV)-based delivery (in combination with ES cell extracts), ... See full document

9

Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination.

Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination.

... using stem cell-derived oligodendrocytes in graft-based remyelination therapy to restore action potential ...efficient and reliable cell source has not been introduced (for review, see ...regarding ... See full document

10

DNA methylation dynamics in human induced pluripotent stem cells over time.

DNA methylation dynamics in human induced pluripotent stem cells over time.

... OCT-4/3 and NANOG have been used as epigenetic markers for iPSCs ...methylated stem cell-specific DMRs and significantly higher expression, and 17 genes with the hyper-methylated stem ... See full document

14

INDUCED PLEURIPOTENT STEM CELLS: A PIONEER IN THERAPY

INDUCED PLEURIPOTENT STEM CELLS: A PIONEER IN THERAPY

... The pluripotent stem cells can potentially be used to counter a wide range of diseases, from diabetes to spinal cord injury, to childhood leukemia, to heart ...iPS cells are similar to human ... See full document

14

A novel strategy for enrichment and isolation of osteoprogenitor cells from induced pluripotent stem cells based on surface marker combination.

A novel strategy for enrichment and isolation of osteoprogenitor cells from induced pluripotent stem cells based on surface marker combination.

... mal cells into osteoblasts, whereas Osx is believed to induce subsequent maturation of osteoblasts and inhibit chondrogenic ...specifically and exclusively expressed in all osteoblasts, showed ... See full document

10

Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells.

Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells.

... these cells through ...35% cells were positive for EGFP expression ...survive and grow in serum-free media mTeSR1 and E8 which were used to maintains human ES or iPS cells [21,22], ... See full document

7

Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome.

Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome.

... research, and has been widely applied as an animal model for studies in physiology, pharmacol- ogy, toxicology, nutrition, behavior, immunology, and neoplasia ...hypertension and diabetes has made ... See full document

11

Scalable passaging of adherent human pluripotent stem cells.

Scalable passaging of adherent human pluripotent stem cells.

... Advancing pluripotent stem cell research to clinical applications requires adapting laboratory-scale cultivation methods to less conventional and current Good Manufacturing Practices- (cGMP- ) ... See full document

9

Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells.

Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells.

... 4 cells/well in CnT-07 ...confluent. Cells were incubated with freshly sonicated fluorescent microspheres ...with cells for different time points (0, 2, 4 or 6 hour) at a final concentration of ... See full document

16

Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells.

Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells.

... from induced pluripotent stem cells (iPSCs) without contamination from unknown substances is crucial to their use in clinical ...progenitor cells, which retain hematopoietic and ... See full document

10

Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells.

Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells.

... hiPSCs and donor cells with respect to hESCs further confirmed the proximity of hiPSCs to their corresponding cell of origin (Figure 5) as compared to other donor cell ...growth and proliferation, ... See full document

10

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

... RE17 and RE19 from S7) carried fewer mutations, of which a subset was shared between them as well as with EPCs from the same ...line and these were not found in EPCs or the individual’s reference ...1D ... See full document

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