[PDF] Top 20 INDUCING APOPTOSIS IN CANCER THERAPY
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INDUCING APOPTOSIS IN CANCER THERAPY
... results in the release of mature, active caspase-8 (composed of a p20/p10 heteromer) into the ...to apoptosis by two different path- ways. In “Type I” cells, caspase-8 directly activates effector ... See full document
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Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.
... grow in a confined space defined by the surrounding tissue, it must overcome the resulting compressive ...compression in such an environment can collapse blood and lymphatic vessels ...stresses in ... See full document
11
Cancer gene therapy
... of apoptosis induction can also be detected in cancer cells when transfection is mediated by the studied RALA/pDNA ...found in HeLa ...induce cancer cell apoptosis in a ... See full document
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Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes
... of cancer chemotherapy is to commit tumor cells to apoptosis following exposure to anticancer agents, and it is generally believed that the induction of apoptosis is the primary cytotoxic mechanism ... See full document
10
Targeting nucleocytoplasmic transport in cancer therapy
... high in-vivo toxicity of LMB might be due to its ability to covalently bind to Cys528 residue of CRM1 and irreversibly block the nuclear export of ...agent in preclinical trials [136] although the mechanism ... See full document
18
Herbal Medicine as Inducers of Apoptosis in Cancer Treatment
... of apoptosis includes morphologic changes for instance, heterochromatin core mass, cell membrane shrink and loosing organelles position in ...cytoplasm. In addition to key morphological changes, ... See full document
7
Apoptosis inducing capacity of Holothuria arenicola in CT26 colon carcinoma cells in vitro and in vivo
... metabolites in sea cucumber species of and their biological efficacy on molecular targets and on cancer models have been suggested holothurians echinoderms a promising source of potent anti‐cancer ... See full document
8
Anticancer peptides : prospective innovation in cancer therapy
... 2+ in organelles, of mitochondrial potential and oxidative stress (Paredes-Gamero et ...2005). In the latter, tumor cell death occurs through an induce of programmed cell death by oxidative stress, which ... See full document
15
Reactive oxygen species, apoptosis and cancer
... of apoptosis has been investigated in many types of cancer and its significance has been well- established for urothelial carcinoma 30–32 ...factor-related apoptosis-inducing ligand ... See full document
4
Compound A398, a novel podophyllotoxin analogue: cytotoxicity and induction of apoptosis in human leukemia cells.
... agent, in order to act effectively and more selectively in the treatment of cancer and to overcome the problem of drug resistance, should act in various molecular targets involved in ... See full document
9
Anticancer prodrugs for targeted therapy
... accumulate in tumor tissue and remain there for a long period of ...seen in the new prodrug of DOX, Ac-Phe-Lys-(para-aminobenzyloxycarbonyl) (PABC)-DOX, which shows a great anticancer efficacy and low rates ... See full document
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Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines.
... of cancer and acts by eliminating potentially deleterious cells without causing such adverse effects, as inflammatory response and ensuing scar ...agents. In last decades, marine natural products, such as ... See full document
8
Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo.
... use in cancer therapy ...considered in the development of drugs targeting the p53-MDM2 interaction. In this study, the ability of aciculatin to ablate MDM2 mRNA was noted (Figure ... See full document
10
CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis.
... Primers in Table S1 in File S1) and cloned into the pGL3-Basic vector ...plated in 24-well culture plates at 1610 5 cells/well and transiently transfected with the pGL3 promoter reporter and pRLSV40 ... See full document
11
Apoptosis as a Target for Gene Therapy in Rheumatoid Arthritis
... ease in which several promising strategies of gene transfer have been ...achieved in animal models using cytokine antagonists, Th-2 cytokines, MMP inhibitors, ribozymes, decoys and pro-apoptotic ...gene ... See full document
9
Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway.
... growth in ovarian ...Cell apoptosis was analysed by annexin V/PI ...phosphorylations in Huaier-treated and untreated ...late apoptosis in SKOV3, SKOV3.ip1 and Hey cells in a ... See full document
14
Structural insights into selectivity and cofactor binding in snake venom l-amino acid oxidases
... ssp. In this work, a new LAAO from Bothrops jararacussu venom (Bjsu- LAAO) was purified, functionally characterized and its structure determined by X-ray crystallography at ...volume in modulating enzyme ... See full document
5
Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons
... found in previous studies (Ambrosio et ...induce apoptosis in neurons by inhibiting and decreasing the signaling of survival pathways such as ERK 1/2 and Akt (Bittigau et ...increases in ERK ... See full document
10
MicroRNAs in lung cancer
... lung cancer (LC), there is still no good early stage LC ...alterations in lung disease, including LC, bring new hopes for the pathogenesis, diagnosis, treatment and prognosis of this ...LC in ... See full document
7
Perspectives of Dendrimer-based Nanoparticles in Cancer Therapy
... incubated in HepG2 cells or human embryonic kidney cells 293 (Choi et ...cytotoxic in HepG2, CCRF and B16F10 cells, at a concentration of up to 5 mg/mL (72 h, MTT ...structure. In addition, low ... See full document
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