[PDF] Top 20 Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
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Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
... role in maintaining tissue homeostasis. Active Caspase-6 (Casp6) is considered a novel therapeutic target against Alzheimer disease (AD) since it is present in AD pathological ... See full document
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Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.
... AOM is a procarcinogen, which upon metabolic activation causes formation of O 6 -methyl-guanine ...chronic inflammation, which greatly enhances the incidence of AOM-induced tumors ...repeated ... See full document
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Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model.
... Obesity is associated with increased systemic concentrations of fatty acids and endotoxin (lipopolysaccharide) that are able to induce an inflammatory response ...TSP1 in macrophage function, bone marrow ... See full document
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Characterization of dextran sodium sulfate-induced inflammation and colonic tumorigenesis in Smad3(-/-) mice with dysregulated TGFβ.
... the colon separated from the cecum. Samples of colon, cecum and occasionally mesenteric lymph nodes were placed into 10% neutral buffered ...The colon was prepared in a ‘‘Swiss roll’’ ... See full document
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[6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling.
... on in vitro cytotoxic effects of [6]-gingerol on SW-480 cell line reported only 17% cell death at this concentration ...differences in the magnitude of effects might be due to the variations ... See full document
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Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
... FasL in neurons was observed after CCI injury in rats ...observed caspase 8 activation following CCI in adult rats ...of caspase 8 has been reported in rat brains after fluid ... See full document
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Cross tissue trait-pathway network reveals the importance of oxidative stress and inflammation pathways in obesity-induced diabetes in mouse.
... expression in six tissues (pancreatic islet, liver, adipose, hypothalamus, gastrocnemius, and soleus), and measured eight quantitative traits (including plasma, glucose, and insulin) in a mouse model ... See full document
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Methylprednisolone stiffens aortas in lipopolysaccharide-induced chronic inflammation in rats.
... Immunohistochemical staining for AGEs and RAGE. Rat aortic rings were fixed in 4% (w/v) formalin and embedded in paraffin. The method for immunoperoxidase labeling has been described previously. The ... See full document
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Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation.
... used in these experiments were male C57Bl/6J, 129S- NPY tm1Rpa /J (NPY-KO), and control 129S mice (Jackson ...at 6–8 weeks of age for 16 weeks unless specified. Animals were housed in a specific ... See full document
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Freund’s adjuvant-induced inflammation: clinical findings and its effect on hepcidin mRNA expression in horses
... disorders is regulated by hepcidin. Hepcidin up-regulation is particularly important during acute inflammation, as it restricts the availability of iron, which is necessary for pathogenic ... See full document
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Sox11 Reduces Caspase-6 Cleavage and Activity.
... Since caspase-6 activity depends on its cleavage, we performed western blot studies to deter- mine whether caspase-6 was still undergoing cleavage in the presence of sox11 (Fig ...of ... See full document
18
Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice
... defects in both the percent (Probe test I) and the number of entries (Probe test II) into the correct quadrant caused by TBI (B, ...differences in swim speed between sham and any of the injured groups ... See full document
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Stimulatory interactions between human coronary smooth muscle cells and dendritic cells.
... also in patients [41] have shown that HMG-CoA-reductase inhibitors limit the progression of atherosclerosis and may even induce its regression and that glitazones are anti-inflammatory and anti-atherogenic agents ... See full document
12
β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.
... independently in separate animals surprisingly revealed pathological carcinomatous features resem- bling heterogeneous mixtures of germ cell tumors (GCTs) composed of seminoma, embryonal carcinoma, and ... See full document
14
Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.
... detectable in colon cancer cell lines, PR- mediated signaling is not possible in these ...used in the WHI study, bind to steroid hormone receptors other than the PR ...important ... See full document
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Retraction: Stanimirović Z, Aleksić N, Kulić M, Maletić M. Fumagillin-induced chromosome aberrations in mouse bone-marrow cells, Arch Biol Sci. 2010;62(1):47-55, DOI: 10.2298/ABS1001047S
... This is a notice of retraction of the article: Fumagillin-induced chromosome aberrations in mouse bone-marrow cells, published in the Archives of Biological Sciences in 2010, ... See full document
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Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
... fluorescence in situ hybridization (FISH) experiments using Cy5- and ALEXA- labelled probes complementary to the csp-1B transcript ...detectable in the somatic cells of wild-type or egl-1(n1084 n3082) ... See full document
15
Caspase-Mediated Apoptosis in Sensory Neurons of Cultured Dorsal Root Ganglia in Adult Mouse
... housed in plastic cages with a 12 hour light/ dark cycle, (21 ± 2 ˚C) with water and food ad ...placed in ice cold phosphate buffered saline (PBS, pH=7.4) and cultured in a medium composed of a ... See full document
6
Prostatic inflammation induces fibrosis in a mouse model of chronic bacterial infection.
... There is accumulating evidence for the contribution of increased collagen deposition and fibrosis to the pathogenesis of BPH/LUTS [3–5,62]; however, the underlying cause of increased collagen deposition in ... See full document
12
Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation.
... mice in all experiments. CIRP 2/2 mice on a background of C57BL/6 were a gift from Dr Jun Fujita (Kyoto University, Japan) and are bred in our animal ...environment in our facility for 5–7 ... See full document
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