[PDF] Top 20 Intact p53-dependent responses in miR-34-deficient mice.
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Intact p53-dependent responses in miR-34-deficient mice.
... The p53 pathway provides a crucial barrier against the neoplastic transformation of primary cells ...which in turn results in stabilization and activation of p53, and consequently apoptosis or ... See full document
12
CD95 is part of a let-7/p53/miR-34 regulatory network.
... CD95 in the maintenance and function of stem cells. In 2004 Richards et ...upregulated in human ES ...differentiation in a similar fashion as the validated let-7 target ...CD95 in stem ... See full document
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Unmet expectations: miR-34 plays no role in p53-mediated tumor suppression in vivo.
... suppressor p53 functions and regulation has a history of unexpected and even enigmatic out- comes [1], despite the status of p53 as the most frequently mutated gene or dysfunc- tional pathway in ... See full document
3
Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development.
... the miR-17,92 cluster with the Shh pathway is only supported by indirect evidence showing that the tumorigenic effects of the miR-17,92 cluster is dependent on the loss of the Shh receptor Patched ... See full document
8
Egr3 dependent sympathetic target tissue innervation in the absence of neuron death.
... nomia in the absence of Egr3 is due to failure of sympathetic neurons to properly innervate target tissues, neuron death or a combination of the two ...role in target tissue innervation independent of ... See full document
10
CD19 LYMPHOCYTE PROLIFERATION INDUCED BY Bifidobacterium animalis subsp. lactis IN C57BL6 MICE EXPERIMENTALLY INFECTED WITH Toxoplasma gondii
... antibodies in the serum of mice: The ELISA technique was used to detect ...infection in the acute and chronic ...diluted in 0.1M carbonate- bicarbonate buffer (pH 9.5) and kept overnight ... See full document
6
Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.
... week-old mice were dissected, cut into small pieces, and red, hemmorhagic islets (as described in [22]) were scored underneath a dissecting ...old mice with a rabbit polyclonal antibody to the Ki67 ... See full document
10
Identifying activated T cells in reconstituted RAG deficient mice using retrovirally transduced Pax5 deficient pro-B cells.
... markers in addition to cytokine-based assays. In contrast to these published methods, we here describe a strategy to identify T cells that respond to any antigen and track the fate of these activated T ... See full document
5
Adaptive gene regulation in the Striatum of RGS9-deficient mice.
... D2R in striatopallidal sMSN ...down-regulated in RGS9-deficient mice. In fact, down-regulation of the Ryr1 transcript by a factor of ...observed in RGS9-deficient ... See full document
12
Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.
... unchanged in the optic nerve and brain, and in fact, it attenuated in the spinal cord in Olig1 2/2 mice (Figure ...observed in the mice without the PGKneo cassette [18], ... See full document
11
Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.
... levels in the mutant p53-expressing samples than in the wild-type p53-expressing and p53-null samples (S2 Table), which could potentially represent genes contributing to the ... See full document
23
Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
... result in atheroscle- rotic plaque rupture and subsequent superimposed thrombus formation ...important in atherogenesis [7]. In addition to the overt leukocyte infiltration into the lesions and ... See full document
14
Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice.
... resulted in a massive expansion of the pleural at the expense of the pericardial cavity (schematized in Figure ...force in this process, a normally sized pleural cavity in absence of a lung ... See full document
9
"Super p53" mice display retinal astroglial changes.
... the p53 gene, produce proteins that inhibit cell division under adverse conditions, as in the case of DNA damage, radiation, hypoxia, or oxidative stress ...The p53 gene can arrest proliferation and ... See full document
7
Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice.
... expressed in various brain areas, especially in regions undergoing activity-dependent synaptic plasticity, but their role in the nucleus accumbens (NAc) is ...unknown. In this study, we ... See full document
8
Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse.
... studies in which biopsies have been performed in patients with AIP. In one large population study [4], 16 patients were found with renal impairment with no other cause than ...more in ... See full document
9
MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs.
... ubiquitination in both mouse and human ES cells [55,56], thus suggesting a potential mechanism for improving reprogramming efficiency by ...levels in 25- iPSCs were slightly but consistently lower than that ... See full document
14
Peripheral surgical wounding and age-dependent neuroinflammation in mice.
... activation in the ...observed in the current ...function in the mice [5]. Moreover, the sham mice also received the bupivacaine injection in the current ...effects in ... See full document
7
An Exploration of Molecular Correlates Relevant to Radiation Combined Skin-Burn Trauma.
... as in vivo biomarkers is supported by their predicted ability to regulate the expression of more than 50% of the human protein coding genes by means of mRNA destabilization and translational repression [9] and ... See full document
16
Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells.
... alterations in cell-cycle profiles char- acteristic of DNA fragmentation (necrosis) compared to patterned DNA cleavage ...(apoptosis). In this way, we were able to visualize cell subpopulations with ... See full document
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