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[PDF] Top 20 Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain.

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Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain.

Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain.

... or the vehicle as indicated in the ...ml of Ni-NTA magnetic agarose beads (Qiagen) for 16 hours at 4 ...saline, the beads were boiled in 50 ml SDS sample ...to the manufacturer’s ... See full document

10

Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages.

Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages.

... in the immune response involved in allograft rejection ...accelerate the immune response, whereas AAM have repair and anti-inflammatory abilities ...IL-13 binding to IL-4Ra and IL-13Ra1 resulted in ... See full document

9

Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury.

Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury.

... rats. The mechanisms of neuroprotection following PPAR-c activation include antioxidative properties and anti-inflammatory ...that ligand-activated PPAR-c controls apoptosis and contributes to ... See full document

10

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) c Activators and Pan-PPAR Partial Agonists

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) c Activators and Pan-PPAR Partial Agonists

... in the absence of exogenous ligands. The structure resembles previous liganded and unliganded PPARs [4,18] but close investigation reveals three saturated medium chain fatty acids (MCFAs) occupy ... See full document

10

Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1.

Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1.

... for peroxisome proliferator activated receptor-c ...in the de novo synthesis of glycerolipids, it has been assumed that LPA synthesized by this route does not have a signaling ... See full document

8

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

... models of inflammatory and visceral pain. (A) Effects of SBFI26, SBFI50, SBFI60, and SBFI62 (20 mg/kg, ...Effect of FABP inhibitors (20 mg/kg, i.p.) upon the first (left panel) and second ... See full document

10

Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile.

Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile.

... in the 39 untranslated regions, leading to suppression of translation and/or degradation of ...colons of C. difficile-infected mice. We focused our efforts on the miRNA-146 family ... See full document

10

Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.

Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.

... assays, the cells were removed by trypsinization and replated in 24 wells plate at density of 1,2610 5 ...gg of plasmids containing wild-type PPARa,d ou c-LBD or PPARd-LBD mutants, DBD Gal-4, 50 gg ... See full document

7

ISSN 1516-635X Oct - Dec 2015 Special Issue Nutrition - Poultry feeding additives 057-064 http:dx.doi.org10.15901516-635xSpecialIssue Nutrition-PoultryFeedingAdditives057-064 Effect of Cottonseed Meal Fermented with Yeast on the Lipid-related Gene Express

ISSN 1516-635X Oct - Dec 2015 Special Issue Nutrition - Poultry feeding additives 057-064 http:dx.doi.org10.15901516-635xSpecialIssue Nutrition-PoultryFeedingAdditives057-064 Effect of Cottonseed Meal Fermented with Yeast on the Lipid-related Gene Express

... investigate the effect of FCSM on lipid-related gene expression in ...number of males and females) were randomly divided into three groups, with six pens per group and 10 birds per ...pen. The ... See full document

8

A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity

A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity

... a ligand-activated transcription factor that is one of three different PPAR subtypes: PPARα, PPARβ/δ, and ...PPARγ. The PPARs play important roles in nutrient homeostasis [11-13] and are ... See full document

10

Epigenetic Activity of Peroxisome Proliferator-Activated Receptor Gamma Agonists Increases the Anticancer Effect of Histone Deacetylase Inhibitors on Multiple Myeloma Cells.

Epigenetic Activity of Peroxisome Proliferator-Activated Receptor Gamma Agonists Increases the Anticancer Effect of Histone Deacetylase Inhibitors on Multiple Myeloma Cells.

... activity of PPARγ agonists on tumor cell lines and animal models have been well described [19, 35, ...however the molecu- lar mechanism of their action as anticancer agents remains, so far, ...on ... See full document

17

Microparticles engineered to highly express peroxisome proliferator-activated receptor-γ decreased inflammatory mediator production and increased adhesion of recipient monocytes.

Microparticles engineered to highly express peroxisome proliferator-activated receptor-γ decreased inflammatory mediator production and increased adhesion of recipient monocytes.

... in the THP-1 cells. After one week of expansion, equal numbers of cells were plated into a tissue culture plate and left unactivated or activated with LPS or PAM3CSK4 for 24 hours, after ... See full document

25

Boron-Based Design of Active Ligands of Vitamin D Nuclear Receptor

Boron-Based Design of Active Ligands of Vitamin D Nuclear Receptor

... On the present day, almost all positions of the vitamin D structure have been modified in order to create new ...Most of the modifications are produced in the side chain since it ... See full document

99

Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with paclitaxel infusion.

Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with paclitaxel infusion.

... regulator of platelet function [37],_ENREF_38 this would be another mechanism of anti-thrombotic action of the PPAR-c ...suggests the possibility of its usefulness in the ... See full document

14

Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats.

Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats.

... regulation of adiponectin, Sirt6, and AMPK may play a role in RGZ’s protective ...action. The up-regulation of Sirt6 and its related genes as well as the activation of LKB1 and AMPK by ... See full document

11

Clinics  vol.70 número12

Clinics vol.70 número12

... level of PPARg mRNA expression in HCV-HIV-co-infected subjects compared to HCV-only subjects in both groups [non-black ...2). The pathology findings demonstrated that more advanced fibrosis in liver biopsy ... See full document

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Assessment of chitosan-affected metabolic response by peroxisome proliferator-activated receptor bioluminescent imaging-guided transcriptomic analysis.

Assessment of chitosan-affected metabolic response by peroxisome proliferator-activated receptor bioluminescent imaging-guided transcriptomic analysis.

... downregulated the expressions of apoB and ghrelin genes in the ...in the liver and is present on very-low density lipoproteins (VLDL), intermediate density lipoproteins, and low-density ...for ... See full document

10

Ligand photo-isomerization triggers conformational changes in iGluR2 ligand binding domain.

Ligand photo-isomerization triggers conformational changes in iGluR2 ligand binding domain.

... Autodock Ligand Docking Calculations with a partially flexible binding site selection were able to generate chemically reasonable protein ligand complex geometries for ATA-3 binding to ... See full document

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The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture.

The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture.

... in the order Nidovirales ...HE ligand/substrate preference. One of these -represented by mouse hepatitis virus (MHV) strain DVIM- displays the presumptive ancestral specificity and targets ... See full document

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Protein tyrosine kinases in Schistosoma mansoni

Protein tyrosine kinases in Schistosoma mansoni

... extracellular binding domain similar to several protein domains that share the Venus Flytap-VFT structure and the cytoplas- matic TK domain, which is similar to the insulin ... See full document

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