[PDF] Top 20 Measuring DNA lesions induced by chemotherapeutic agents – DNA repair and DNA Damage
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Measuring DNA lesions induced by chemotherapeutic agents – DNA repair and DNA Damage
... nonselective chemotherapeutic agent is a class I anthracycline with aglyconic and sugar ...diffusion, and after which it binds to target enzymes such as topoisomerase I and II creating a range ... See full document
66
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.
... assays and immunoblot analysis showed phosphorylated p19 in the cytoplasm followed by a translocation into the ...import induced by DNA ...irradiation and chemotherapeutic ... See full document
14
Sunlight damage to cellular DNA: Focus on oxidatively generated lesions
... routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the most significant environmental DNA-damaging agents to which humans are ...UVB and UVA, triggers ... See full document
15
Use of the Comet Assay to study the role of MGMT, MMR and p53 in the repair of alkylating DNA damage
... alkylating agents. It is thought that these repair pathways are interconnected and although they can be defined separately, they perform functions that overlap with each other (Knudsen et ...the ... See full document
99
DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells.
... regulation, and tumor regression. Generally, chemotherapeutic drugs induce the death of apoptotic cell in a mitochondrial pathway by activating BH3-only proteins and neutralizing the ... See full document
6
Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats
... euthanized and the hearts were excised, weighted, then washed with normal saline and finally fixed in 10% neutral buffered formalin, as previously ...paraffin and tissue sections were cut and ... See full document
11
Association between the c.910A.G genetic variant of the XRCC1 gene and susceptibility to esophageal cancer in the Chinese Han population
... X-ray repair cross-complementing 1 gene (XRCC1) is one of the most important candidate genes for influencing susceptibility to ...56.62) and 387 cancer-free controls (males: 251, females: 136, mean age: ... See full document
5
MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells.
... [29,38] and tumor xenografts [39], we found that MLH1-deficient HCT116 cells were resistant to 5-FU compared to MLH1-proficient HCT116+3 ...[7,8] and a meta-analysis ...oxaliplatin and SN-38 in ... See full document
12
Effects of UV radiation exposure on DNA and DNA repair enzymes
... of DNA injuries, cells have developed a sophisticated DNA maintenance apparatus, consisting of different repair systems (Figure ...of DNA lesion, as a whole they counteract most of the ... See full document
144
Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo
... coverslips and placed in a 60 mm ...X-100 and blocked with ...2000 and incubated at room temperature for 2 ...USA) and then analyzed using a Zeiss Axiovert 200 fluorescence microscope with ... See full document
10
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.
... shown by their high ( ...uncoordinated and wobbling gait or recumbency: 3; near death recumbency: ...impairment and scores were progressively lower in hMTH1 hemizygous and hMTH1 homo- zygous ... See full document
14
Relationships between chromatin remodeling and DNA damage repair induced by 8-methoxypsoralen and UVA in yeast Saccharomyces cerevisiae
... The DNA end-binding Mre11-Rad50-Nbs1 (MRN) complex, which is involved in recognition, signaling and repair of DSBs in mammalian cells, specifically binds to the g-H2AX by the Nbs1 ...Nbs1 ... See full document
8
DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions
... Specific DNA repair pathways from Trypanosoma cruzi are believed to protect genomic DNA and kine- toplast DNA (kDNA) from ...to repair nucleotides oxidized by reactive ... See full document
10
Effects of melatonin on DNA damage induced by cyclophosphamide in rats
... 24 and 48 h after CP treatment (50 ...100 and 10% dimethyl sulfoxide added just before use), and kept at 4 6 C for 1 ...guanine and formami- dopyrimidine that occur in spontaneous breaks in ... See full document
9
Actividade moduladora de extracto de Ginkgo biloba no ciclo celular de Saccharomyces cerevisiae e capacidade de reparação de danos de DNA em células sob stresse replicativo
... irradiation- induced oxidative organ injury in rats [70], protects against radiation-induced lethality, lipid peroxidation and DNA damage in humans [71], however, mechanisms of its ... See full document
46
Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.
... the damage sites, and does not impair the condensin I-PARP1 ...mM) and fixed at one hour after ...hCAP-G, and PARP1 as ...DMSO-treated and NU1025-treated cells as in ...group and ... See full document
7
Distribution of DNA repair-related ESTs in sugarcane
... de DNA são requeridas para manter a necessária estabilidade genômica e garantir a sobrevi- vência do organismo, frente aos efeitos deletérios causados por fatores endógenos e ...de DNA encontrados na ... See full document
6
Metformin (dimethyl-biguanide) induced DNA damage in mammalian cells
... on DNA mole- cules is ...activation by way of ...effects by playing a role in the gene regulation and signal transduction pathways possibly involved in de- fensive mechanisms against oxidative ... See full document
6
Mre11 assembles linear DNA fragments into DNA damage signaling complexes.
... during DNA replication. MRN also plays a role in the response to DSBs created by DNA ...[ATLD]) and mutations in the ataxia-telangiectasia-mutated (ATM) gene lead to defects in handling ... See full document
11
Several pathways of hydrogen peroxide action that damage the
... (katG) and HPII (Mukhopadhyay and Schellhorn, 1997). DNA microarray techniques have detected several other new OxyR-activated genes including the henH heme bio- synthetic gene; the six-gene suf ... See full document
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