[PDF] Top 20 Mechanisms of RON-mediated epithelial-mesenchymal transition in MDCK cells through the MAPK pathway
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Mechanisms of RON-mediated epithelial-mesenchymal transition in MDCK cells through the MAPK pathway
... The epithelial-mesenchymal transition (EMT) is involved in neoplastic metastasis, and the RON protein may be ...involved. In the present study, we determined ... See full document
9
Inhibition of pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04.
... prevented the nuclear accumulation and translocation of SMADs proteins in ...are mediated through numerous signaling pathways, such as TGF-b-induced Erk activation and tyrosine ... See full document
11
Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition.
... use in humans with renal can- cer and liver cancer ...inhibits epithelial cancer cell proliferation and EMT ...kinases, in- cluding vascular endothelial growth factor R2 (VEGF-R2), platelet-derived ... See full document
11
Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition.
... one of the leading causes of cancer-related deaths worldwide ...are the major reasons for treatment failures and a poor prognosis ...by the clinical observation that malignant tumors ... See full document
8
Afadin downregulation by helicobacter pylori Induces epithelial to mesenchymal transition in gastric cells
... Activation of an EMT program has been proposed as the critical mechanism for the acquisition of malignant phenotypes by epithelial cells (Moreno-Bueno et ...2008). The key ... See full document
13
Role of Bmi-1 in regulation of ionizing irradiation-induced epithelial-mesenchymal transition and migration of breast cancer cells.
... tumors, in- cluding breast cancer. It triggers the production of reactive oxygen species, which damage the DNA and induce apoptosis or senescence of cancer cells ...on ... See full document
10
MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4.
... number of transcription factors, including Snail, Slug, Twist, ZEB1, and ZEB2, regulated EMT during tumorigenesis ...decreased the expression of Snail, ZEB1, ZEB2, but not Slug or Twist, at both mRNA ... See full document
9
Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway.
... particularly in the maintenance of intestinal homeostasis in a complex manner notwithstanding the diversity of an intestinal flora between ...to the maintenance of ... See full document
15
Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells.
... by the formation of epiretinal membranes through a defective wound repair process, occurs as a complication of rhegmatogenous retinal detachment ...is the primary reason for failure ... See full document
15
Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways.
... Japan). The annexin V-FITC apoptosis kit was obtained from Medical and Biological Laboratories ...Germany). The Mitochondrial/Cytosol Fractionation Kit was obtained from BioVision (San Francisco, ...OR). ... See full document
14
J. Bras. Nefrol. vol.34 número4
... HK2 cells were grown on chamber slides and fixed with 96% alcohol after 24 hours in experimental ...0.01M), cells were incubated with primary mouse monoclonal antibod- ies against α-SMA (Dako, N1584) ... See full document
6
Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors.
... [r] ... See full document
8
CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.
... regulate the proliferation of both tumor stem cells and normal stem cells ...proliferation of both tumor and normal stem cells may result in the same outcome for ... See full document
12
Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.
... claudin-2 in these clones, but faint bands appeared at a molecular weight lower than that of wild-type claudin-2 ...2B). The faint bands were detected by two different antibodies that recognize ... See full document
22
Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.
... involved in tumor progression, but little is known about these channels in ...expression in breast tumor tissues was detected relative to that in non-tumor breast tissues, but there was no ... See full document
17
A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition.
... control the expression of E-cadherin during the EMT, we calculated the regulatory effects of the upstream regulators of ...Out of 1732 potential regulators, ... See full document
17
Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells
... Apoptosis of RD cells was observed using annexin V-FITC/PI binding assay under a fluorescence ...cDNA. The expres- sions of 56 genes of MAPK signaling pathway in ... See full document
8
Upregulation of TrkB promotes epithelial-mesenchymal transition and anoikis resistance in endometrial carcinoma.
... investigated the expression of TrkB in solid cancers [6–8], this is the first study to address the function of TrkB in human ...expressed in human endometrium, and ... See full document
17
TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.
... with the gain of a mesenchymal phenotype. In this model the loss of CDH1 expression is only an indirect proof but suggests that TWIST1 might directly bind DNA to induce ... See full document
11
Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.
... signaling. In these tumors EGFR plays an important role in cell motility and invasiveness and prompts the EMT process possibly via Src ...reasons, the maintenance of gefitinib after ... See full document
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