[PDF] Top 20 Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... consists of a group of six telomere-specific proteins; telomeric repeat binding factor 1 and 2 (TERF1, TERF2) and protection of telomeres pro- tein 1 (POT1) interact directly with TTAGGG ...stage ... See full document
12
Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer.
... 85% of CRCs are characterized by chromosomal instability and telomere dysfunction may be considered a major driving force in generating this feature ...end of chromosomes which are associated with ... See full document
12
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
... transcription of telomerase reverse transcriptase ...though regulation occurs in context of a broader ...on telomerase regulation have not been investigated, ... See full document
19
Assessment Of NPK In Human Male And Female Urine For Its Fertilising Potential In Agriculture
... se of excreta on arable land secures valuable fertilisers for crop production and limits the negative impact on water bodies [29,13, ...impact of excreta disposal usage would always be less than that ... See full document
9
HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b.
... Visualization of BARD1ω fused to the biotin tag in HEK293T ...scheme of Fδ BARD1 and BARD1ω1 ...localization of BARD1ω1-bioTag. (C) The distribution of recombinant BARD1 full length and ... See full document
16
Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors
... ability of docking programs and their scoring functions to predict the relative biological activity of triazole ...NNRTIs. In to- tal 111 known 1,2,4-triazole and 76 other azole type NN- RTI were ... See full document
18
Antiretroviral resistance mutations in human immunodeficiency virus type 1 infected patients enrolled in genotype testing at the Central Public Health Laboratory, São Paulo, Brazil: preliminary results
... one of the major obstacles for pharmacological human immuno- deficiency virus (HIV) ...most of them (60%) exposed to three or more regimens, and 28% of them have started therapy before ... See full document
6
Formal modeling and analysis of ER-α associated Biological Regulatory Network in breast cancer
... expression of both IRS-1 and IGF-1R in BC cells (Fagan & Yee, 2008; Lee et ...involved in the progression of BC metastasis and they should be targeted together for its ...results of ... See full document
33
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
... Production of soluble recombinant HBV polymerase or domains of the polymerase is notoriously difficult, and our experience with the HBV RNAseH domain was no ...levels in E. coli and was a minor ... See full document
15
Laboratory capacity building in Asia for infectious disease research: experiences from the South East Asia Infectious Disease Clinical Research Network (SEAICRN).
... Disease Clinical Research Network (SEAICRN) is a collaborative partnership of hospitals and institutions in Thailand, Vietnam, Indone- sia, and ...and clinical and laboratory management ... See full document
5
Effect of estradiol and bisphenol A on human hepatoblastoma cell viability and telomerase activity
... roles in the etiology of HB (4). Estrogen maintains the function of sex organs and reg- ulates metabolism in humans ...sources of estrogen include pesticides, plastics, detergents, ... See full document
6
Analysis of Respiratory Syncytial Virus in Clinical Samples by Reverse Transcriptase-Polymerase Chain Reaction Restriction Mapping
... Comparison of RNA-PCR sensitivity with the plaque test assay and IFI - The “Long” strain was cultured on HEp2 cells in flasks with a surface area of 25 cm 2 , containing 5 ml of MEM, 5% fetal ... See full document
6
Diagnosis of Dengue by Using Reverse Transcriptase- Polymerase Chain Reaction
... copies of a portion of the viral ge- nome (capsid/prM) were produced and amplified using two consensus primers designed to anneal to any of the four dengue virus ...results in different bands ... See full document
5
Genetic and epigenetic mechanisms involved in regulation of STEAP1 gene expression in LNCaP prostate cancer cells
... Prostate cancer is the second most frequently diagnosed type of cancer and the fifth leading cause of cancer death in men ...alterations in genetic and epigenetic ... See full document
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Field Cancerisation of the Upper Aerodigestive Tract: Screening for Second Primary Cancers of the Oesophagus in Cancer Survivors
... Risk of developing a second malignancy should be anticipated after curative treatment of ...incidence of second primary cancers in OSCC survivors. Because of the high mortality ... See full document
8
Decreased phenotypic susceptibility to etravirine in patients with predicted genotypic sensitivity.
... samples of 20 HIV-1 infected patients were retrospectively included from the HIV cohort at Department of Infectious Diseases, Karolinska University Hospi- tal, Stockholm, Sweden (Table ...1). Of ... See full document
9
Estrogen-Responsive Genes Overlap with Triiodothyronine-Responsive Genes in a Breast Carcinoma Cell Line
... increase in the survival of hyperthyroid patients with breast cancer, whereas we have identified a biological link between breast cancer in postmenopausal women and subclinical ... See full document
8
Clinical and Biochemical Evaluation of HIV-Related Lipodystrophy in an Ambulatory Population from the Hospital Universitário Cassiano Antonio de Morais, Vitória, ES, Brazil
... center in Vitória, ES, ...absence of lipodystrophy. Use of protease inhibitors (PI) was associated with an increase in serum triglycerides ...not of total cholesterol (TC) or HDL ... See full document
5
Prevalência de resistência transmitida do HIV-1 aos antirretrovirais no Brasil, pré- início de tratamento
... da transcriptase reversa e protease, com análise do perfil mutacional por grupos populacionais de pacientes cronicamente infectados pelo HIV-1 e não tratados, porém com indicação de início imediato de ... See full document
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During follow-up of patients, it was observed that a recurrence of VTE can occur even when they are on full anticoagulation, which suggests that the disease is more aggressive and prognosis is worse. 1,6,27 RISK FACTORS AND PATHOGENIC MECHANISM OF THROMBI
... risk in cancer patients at the start of ...rate in patients who had persistent leukocytosis after the first chemotherapy cycle was significantly higher than the rate among those with ...marker ... See full document
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