[PDF] Top 20 Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival.

... negative prognostic impact of MCT has only been demonstrated when MCT1 is co-expressed with CD147 or p53 ...that MCT1 is capable of transporting lactate both in and out of the ... See full document

... found in the literature that can help to explain the mechanism underlying MCT1 expression in the ...nucleus. In fact, large-scale mapping of human protein-protein interactions by mass ... See full document

... region in NSCLC and its potential clinical relevance, our data indicates histological subtype-specific deviations in terms of allelic loss frequencies and prognostic ...loss in SqCC ... See full document

... family is composed of four members, FGFR1/2/3/4, which are activated by interacting with fibroblast growth factors (FGFs), resulting in the activation of downstream signal- ing pathways including ... See full document

... (NSCLC) is considered a potentially curable disease following complete resection, patients have a wide spectrum of survival according to stage (IB, II, ...expression in nine genes could help ... See full document

... overall survival ranged from 1 month in case of steroid application only, over 3 months if radiotherapy was applied to 9 months for the subgroup that underwent surgical resection ...patient ... See full document

... Hospital, an oncology referral center and part of the Santa Casa de Misericórdia de Porto Alegre Hospital Complex, in the city of Porto Alegre, located in southern ...IV) NSCLC and admitted to ... See full document

... CD3 is a part of the T cell receptor (TCR) complex on a mature T ...CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic ...CD8 ... See full document

... leukaemia. Prognostic factors, such as bone marrow fibrosis, lactate dehydrogenase and β2-microglobulin elevation have been described, but treatment is mainly based in the International ... See full document

... involved in DNA repair and gene expression [236]. Accordingly, it is suggested that ADP-ribosylation may regulate VEGF transcription, in a lactate- mediated mechanism ...growth in ... See full document

... role in cellular metabolism and are essential for transport of monocarboxylates, such as lactate, across the plasma ...characterized. MCT1– MCT4 isoforms are proton symporters, which have lactate as a ... See full document

... activity in pros- tate adenocarcinoma could suggest or anticipate an early diagnosis of hormones refractoriness behavior and thus justify changes in therapeutic ...(8), is the most frequently ... See full document

... treatment in the cell lines more sensitive to 3-BP, ZR-75-1 and ...alterations in actin structure by fluorescence microscopy using Alexa Fluor 488 Phalloidin, a fluorescent probe with high affinity ... See full document

... Autophagy is an evolutionarily conserved cellular catabolic process that is characterized by the delivery of cytosolic material and organelles to lysosomes for bulk ...autophagy is associated ... See full document

... disease, 1 but what happens during this initial period is not ...biochemical marker. Such a marker could provide an earlier, more reliable, and accurate prognostic indicator for ... See full document

... increases after acute ischemic stroke and the higher the high sensitive C-reactive protein levels, worse is the prognosis, in terms of clinical status and outcome as per scandavian stroke scale and the e ... See full document

... displayed in Figure S1) positive skewness at fine-texture and lower kurtosis at coarse-texture were able to significantly differentiate K-ras mutation from pan-wildtype (p = ...Difference is skewness at ... See full document

... tercile in CRP values were, respectively, ...as an independent predictor of death or death combined with ...ours is the only study that we are aware of in which this issue was ... See full document

... at 4°C, filtered and injected onto a high-performance liquid chromatography (HPLC, Shimadzu, Japan) equipped with two LC-20AT pumps, one auto-sampler SIL-20AC HT, absorbance detector SPD-M20A, and a CBM-20A system ... See full document

... reflects an increased neutro- phil and/or a decreased leucocyte ratio. It is gen- erally accepted that the inflammatory processes in the tumor microenvironment play a crucial role in promoting ... See full document